onedayillsailagain

Coffee makes my HPPD much worse, as well as anxiety. I was actually hooked to drinking 20+ coffees for a while after I acquired HPPD, because I'd stay up all night researching. Once I stopped, my symptoms improved. You could try reducing your intake to 0.5-1 cup in the morning. I do miss coffee. If it wasn't for the anxiogenesis, I'd probably still drink it regardless of visual symptoms.

I've ordered all of these and intend to try them. Sarcosine is still on its way, but I've received the others already. Started today with Glycine at 800mg/kg. I have enough for 7 days, and will keep to solely Glycine for the time it lasts. So far all I can say is that I just had an amazing siesta after taking it. It is known by its sleep-enhancing qualities, so this should come as no surprise. I think I will take this OD at night. Any comments are welcome.

Welcome Jordan. It does sound like you may have DP/DR. Can you further describe your visual symptoms? Indeed it has been reported that anxiety can aggravate HPPD as well as DP/DR. For your GP you can use the DSM criteria of HPPD to help explain. As for the DP/DR aspect; it's in DSM as well, though you'd have to find that one yourself as I don't have it. Should be online. Be prepared that your GP may not know what it is, nor acknowledge it, or how to handle it. He might class it as a depression and try to prescribe you medication. If he does, do come back and let us know which medication. You can also read of experiences with different medications here. Other than that you can try being referred to a therapist. Some people find this helps, others don't. If you've any other questions, don't hesitate to ask. Hoping to have helped, odisa

Thanks for you concern Ghormeh. I took Nefi the day before yesterday, and it seemed to help. Took it yesterday to no avail, possibly even adverse events. I was feeling bad enough that I decided not to take the third dose. Currently I am looking to acquire Sarcosine, which turns out to be difficult. Perhaps I'll try Pregnenolone as well, yet I'll read more literature about that before doing so. Regarding neurogenesis: Syntheso, I was going to ask you if you were interested in helping hope1 and I conduct a group buy for NSI-189. VIsually, I doubt it will help, but for all other co-morbid symptoms, it seems to hold great potential. Especially when taking HPPD from a PTSD standpoint.

Yeah.. After my last update I used Nefi once more. Was feeling relatively better, and got offered cocaine again. I should've known, haha. Well I did, really. Feeling straight back to out of whack again. Stupid on my part. Just sitting at home waiting for the worst to pass, and I've just ordered some Etizolam for the short-term. Quite confident it'll pass over the course of days, so just vegetating for now again. Just took 10mg Colu, I'll see how that pans out. TL;DR: No real updates. It's very good to read Nefiracetam is working so well for you! I'll give Nefiracetam a try again once I get on top of this (and stay on top of this). Cheers!

I did? Must be losing more marbles then.. Well it was just something I came across which appears to upregulate DA receptors.. No personal experience (yet). Perhaps worth looking in to more effective substances with regards to DA upregulation then.. tinnitus doesn't sound too fun (pun intended). Did the tinnitus diminish after cessation?

Indeed probably dopaminergic troubles.. I'd suggest Uridine and other DA upregulation methods. Possibly try a MAO-B inhibitor at low dose for symptom mitigation. That's all I got for now.. might revisit this later and hopefully give you a better answer. Cheers.

Hey Puppeteer, I was taking 3 pills a day, which I think would be 3 x 12,5 = 37,5mg. I wouldn't know about interactions with Lamotrigine, but in my experience Tianeptine is rather benign stuff. I think there's relatively little mention of it because it is not available in the US afaik. Anyway, I'll send you a PM in a few.

I've tried Tianeptine for a short while (2-3 weeks).. Perhaps I didn't give it a long enough trial. I still have some lying around though. To be honest I didn't notice much. Perhaps the first few days some anxiolysis, after that nothing. But I'd say that it's worth a shot; and definitely preferable over most SSRI's. I had 0 adverse effects.

I am / will be trying to join the NSI-189 group buy.

http://en.wikipedia.org/wiki/Flibanserin

I don't see why not. The only issue I can see is that most 5HT inverse agonists are research chemicals/in clinical trials, hence you'd have a hard time getting some if there's no active group buy going on.

Yes that would be nice. As for yesterday's experience: I had instances with what one would clinically call "skin conductance", but I'll just call it goose bumps, when listening to music. Also, in general I felt more emotion. However, after the second dose, I started noticing pretty severe brainfog, which worsened as time passed. Also, some (recurrence of) anxiety. I had a glass of wine, smoked a bowl of Passiflora, put on a meditation track, and fell asleep. My sleep was pretty great though, and I remember actually not thinking about the things that have been bothering me for quite some time. For just a moment, I forgot I had HPPD and all associated nastiness. As for today: I woke up feeling surprisingly clearheaded. Of course, this is quite the relative thing; it didn't have me singing, but I was in a decent mood and felt fine. Took 110mg this morning. Had a bout of brainfog. Not sure if it's still here, but apparently I'm quite able to hold a conversation. Not particularly anxious at the moment, yet I don't feel cognitively on top. I'll stick to aforementioned plans of dosing today, and am hoping the brainfog is a transient thing which will dissipate over time. Having gone through the literature on Nefi a bit, I've decided to stick with it for as long as my supply lasts (which should be around 9 more days). Apparently after 7 days, effects should be more pronounced. I'll update again if anything noteworthy/significant happens, and otherwise when my supply finishes.

Well put Synth. I doubt Ch Bitartrate will actually do anything by itself. Other sources of choline, like CDP-choline or Alpha GPC, I'm not so sure of. CDP-choline apparently upregulates DA receptors. Anyway. I capped 100mg exactly one hour ago and took it with milk. Not sure if I'm noticing anything. Perhaps anxiolysis if anything. Nothing adverse so far. I'll take another 100mg tonight. Tomorrow I'll do 100mg TID. If no results, I'll up to 150mg TID. Haven't exactly fully recovered from last week, so that may be playing a part as well.

I hadn't seen this was Pregnenolone Sulphate. From wiki: Interestingly, unlike pregnenolone, pregnenolone sulfate is a negative allosteric modulator of the GABAA receptor[5] as well as a positive allosteric modulator of the NMDA receptor.[6] In addition, it has been shown to activate the transient receptor potential M3 (TRPM3) ion channel in hepatocytes and pancreatic islets causing calcium entry and subsequent insulin release.[7] And here's another study: http://www.ncbi.nlm.nih.gov/pubmed/11861317. And I also suggest this one (pregnenolone administration increases PregS concentrations+ its effects in schizophrenia): http://www.sciencedirect.com/science/article/pii/S030645221100786X. Maybe supping with pregnenolone alone would suffice to bring about positive change? It's pretty available, like here. Also, I don't know about D-Cycloserine, but I wouldn't be surprised if GLYX-13 hits the nootropic market this year. Even if you were an organization, GLYX-13 would still cost you about 7-8 grand for a single dose, so probably best to wait until it becomes available to the nootcommunity. Indeed given the known efficacy of prodopaminergic therapy, that may be what's attributable to the benefits of NMDA antagonists. I agree that NMDA antagonists are probably best to be avoided (that includes alcohol!). Perhaps a multi-faceted approach of pro(acetyl)cholinergic, prodopaminergic, proNMDAergic, proGABAergic, and condynorphic, might be interesting? Though that would obviously be a tad difficult to create such a stack. Just a random thought really.

Yes, or perhaps a combination of both.. Preg for the long-term, Nefi for the short. I'd agree that Schizophrenia's negative symptoms can apply to a wide variety of mental distress, so it's no surprise that they're similar to HPPD's co-morbid symptoms. I've read one report of Nefiracetam completely reversing positive psychotic symptoms, but that just so happens to be from a guy who ripped me off, so I'm not too trusting of the validity of that report. Also, I was looking into Uridine for upregulating my recently downregulated DA receptors.. I read that NMDA antagonists upregulate DA receptors, so I'm wondering whether NMDA agonism may downregulate DA receptors, though obviously that's a simple train of thought.

I'm being lazy, scatty, and just woke up in the middle of the night, so forgive me for not elaborating, but here: http://www.ncbi.nlm.nih.gov/pubmed/23716622

Hello, welcome to the forum and thank you for adding your story Alas, personally I have not recovered yet, so I can't exactly comment on how to do so. However, there's a general consensus on what does seems to help. In a nutshell: Exercise, relaxation, meditation, B-vitamins and other general-health supplements like a decent multi-vitamin and Fish Oil. If you search the forum, you'll find other supplements that have personally helped people, although you won't find (m)any accounts of them actually curing people. Others that seem to help people are Magnesium and NAC for example. 5-HTP doesn't really seem to do much from what I've seen and experienced. Alternatively, if you're going down the amino acid route, try DL-Phenylalaline, L-Tyrosine, L-Tryptophan, or a combination thereof. I read that you'd rather not take any drugs/pharmaceuticals. This is fine, as it's your personal choice after all. Just keep in mind that there are accounts of people having benefit from them, some as far as total remission. However, indeed also accounts of them worsening symptoms, sometimes past cessation of them. Hence it would be a good idea that if you were to decide on trying a drug, to cross-reference here for experiences. You might want to check out the Supplements That Work thread as a start. Other than that maybe other members might be able to recommend things as well. All the best, odisa

Sinemet inducing Parkinson's.. ironic right? I suggest you give it at least a week before trying out anything else. Alternatively, if it doesn't work (sufficiently) you could try adding a (weak) MAO-B selective inhibitor. Yes, it would appear that the weather tends to affect my mood moreso than it would do otherwise without HPPD. Best of luck!

Looks nice! ALCAR would be transformed to Acetyl-CoA, which is the other building block of ACh, so it should have effect in some regard, however what exactly I don't know. I've ordered a 2g sample from a Dutch company, which should've been here yesterday... I think it'll be here by Tuesday at the latest. In the meantime I've been a bit worried about the schizophrenia-like experience you describe. Doesn't sound too bad, yet I had a mild semi/prepsychotic episode yesterday (yeah I'm never doing blow again), and one psychosis a year is more than enough for me.. I might have to give it a week or two before I try it, just be safe&let my body recover (still feeling a little out of whack). Any updates? EDIT: just received my sample. EDIT 2: Do you dose sublingually or simply swallowed? I'm just assuming the latter for now.

Good to hear jay! Hope it sustains itself

Hoping that with treating your Lyme's that you'll see mitigation of HPPD as well I think it would be likely to be so. Be well man.

Awesome.. Do you think either Colu or Nefi to be superior to the other? That's like 50-70 grams of Glycine man.. Haha. I was thinking of trying that myself. I'm very interested to see how that pans out, however (presumably you know this already) it would probably be best not to combine with Nefi.

Interesting note on the brainfog. Guess it's a rather wide term though.. Could be anywhere from slightly out of it to totally dazed out in to space. As you put it, it doesn't seem to be too much of an issue, relative to what already is experienced with HPPD. Good to know it seems to lift with TID dosage. Yeah I can see what I can find out.. I suspect he'll just suggest cycling off on the weekends though.. I suppose it's a matter of binding affinity as well, so perhaps @StateOfRegret can help out with that one? NSN seems like a genuinely proper company, and I'd prefer to buy from them, however the shipping rates are a bit off-putting, though I haven't really looked in to that. I'm considering ordering from a EU supplier, or maybe even just a sample from a Dutch company (the latter option would let me try it as soon as Friday). Of course ordering from NSN would be a tad more useful w.r.t. data, but I'm not feeling particularly meticulous about it to be honest (plus.. impatience, hehe). Anyway: as for head tension/pressure I suggest playing around with choline intake, as it is a known symptom of cholinergics (though I don't remember whether it was hypo- or hypercholinergia). Idk whether you eat eggs etc, but you could try cutting all dietary intake of choline one day, and supplementing with extra choline another, and see if that makes a difference.. Maybe play with ALCAR if you happen to have it, though I wouldn't go out of your way to buy it. Also, B-vitamins usually have added choline; just a reminder. Other than that I can't really think of anything at this moment.. perhaps tomorrow I might think of something. It seems to be a common affliction with racetams.. Two other things come to mind: hydration and possibly cerebrovasodilators, though of course proceed with caution with the latter considering the concurrent use of Guanfacine. Also looking forward to any elaboration of your experience; no pressure though

Yeah was worth it, no regrets Anyhow, took 60mg Colu at once today in an attempt to mitigate residual fogginess. Nothing. I think the past few days have cancelled out any noticeable effects. Well come to think of it, I actually notice I'm not nearly as anxious as I was when I woke up this morning (residual post-blow hypervigilance). Pretty chill now, despite the fog. Dunno if that's attributable to Colu, but I'm feeling better, which I'm fine with for now. Gonna give Colu a rest for the coming 2-3 days before giving it another go.