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Fawkinchit

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Fawkinchit last won the day on December 9 2023

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  1. A lot of this information is actually really good, and certainly a potential hypothesis. The microbial theory definitely merits further investigation, and could certainly be a possible cause for HPPD.
  2. Yes! Definitely, maybe not likely, but I did have significant improvements after about 5 years. Some of the most improvement actually.
  3. Man sorry about your condition thats a really unfortunate series of events. As far as the potassium channel openers, i really have no idea, since they are new to me. However, in my opinion, its typically best to sit back and wait for other people to go first lol. When drugs are released after FDA approval it really just means now the public are testing grounds. A lot of medications have been approved and had deleterious effects. Its hard to say how anything will impact HPPD, since its a very strange condition to begin with. I do appreciate you sharing your information and story though because its very unique, and gives further insight in to the cause of this condition. Also, if I were you, I would open a lawsuit against the doctors treating you, if you haven't already.
  4. All fine by me, he was constantly going around harassing and abusing members. It was getting old. I think it's Giome, but when i asked him he said it was another guy from the HRF or whatever its called. I actually was going to help them with their website and the google ads funding, but I couldn't get it to work for the payment, and Giome never could give me the authorization emails for the supposed ads grant. He said he could access it from his account, but wouldn't let me log in to it. Then he went absolutely nuts texting me abusive speech etc. I just told him I wasn't going to help anymore and good luck. makes me wonder as well if he just fabricated the google ads grant. I think they are just bummed that the research project produced nothing, and went from 80,000 to 800,000 in monetary needs. So in their frustration they are going around abusing, harassing, and blaming everyone amidst their own angst.
  5. Honestly I wish that were the case, I wish I could have that luxury, of only caring to parade around.
  6. Yes, but its progress, a lot of progress actually, and its better than just going around trying to convince people that what they are doing to help is not helpful.
  7. I would actually be capable if I had the time and money for the equipment. That's actually what I have been working on a lot in the last few years, which is why I haven't posted here as much. So far no success yet. But, there is still time.
  8. Just posting this study that shows that there are increases of glutamate in the prefrontal cortex from LSD. It states an increase or 206% from the second drugs tested but seems to bypass the percent increase from LSD. I think i looked in to this once and the increase wasn't as substantial with LSD, no where near in range to suspect possible glutamate cascade toxicity. But I will look in to it again incase I can find anything else or incase I missed anything. https://www.sciencedirect.com/science/article/abs/pii/S0006899304011813
  9. Hi, sorry I am just getting back to this. How do you know that the diffuse cerebral atrophy was from your early childhood? You really would have to tell us also, have you used drugs before you developed the symptoms you are experiencing? Usually the only things that are seen in an MRI for HPPD are microlesions, or micro hyperintensities. The things listed on your MRI are quite different for that. However, most HPPD sufferers have nothing on their MRI. If you have used drugs, and you have HPPD like symptoms, it is likely that you have HPPD. Please also explain what your symptoms are.
  10. I'm not quite sure yet, it will take some time to gather up possible reasons for dysfunction, and I'm not sure how much information will likely be available on the matter as well.
  11. Adding this also, as its a super interesting study on 5ht2a receptor dysfunction, and I think said dysfunction is something that necessitates further investigation. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4362472/
  12. Thought this was really interesting, seems like its saying that downregulation of 5ht2a receptors are long term... Edit: Realizing that I think they mean while still on the antagonists. Although I do want to state that there may be unknown variables in the premise of downregulation/upregulation that may have not been fully explored yet. Maybe there are permanent changes that can possibly occur. Its extremely interesting as well, that, as I think I have brought up before, that schizo/OCD/and other conditions appear to be linked to 5ht2a receptor dysfunction, which alternatively I suppose may also be the case with HPPD. If I remember correctly there is consistency with HPPD and previous mental health conditions of the same lines. Even I personally have had mild OCD. It is strange as they state as well that the antagonist induce downregulation, instead of upregulation, which is quite paradoxical as they state. Functional regulation of 5-HT2A The functional regulation of 5-HT2A involves desensitization and re-sensitization, which differentiates 5-HT2A from conventional GCPRs (e.g. the B2 adrenergic receptor) and prevents overstimulation.1 At the molecular level, desensitization and re-sensitization of the receptor are controlled via clathrin-mediated receptor internalization and recycling.1 This dynamin-dependent internalization can be triggered by antagonists or agonists of the receptor and exists to allow the recuperation of signaling competence.1 Long-term use of 5-HT2A antagonists has been shown to downregulate 5-HT2A expression1 and, while the mechanism of this "paradoxical regulation" is unknown, it is likely due to functional regulation. https://www.reprocell.com/blog/biopta/5ht2a-serotonin-receptor#:~:text=5-HT2A receptor location,ligand binding experiments in rats.
  13. Yah I understand. Its a really difficult condition, and definitely has better times, and worse times. It gets really difficult when the flare ups last, its the worst when they seem to last forever. How long have you had it for?
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