onedayillsailagain

I've done a quick search on Nefiracetam experiences. This one really looks like a shot in the dark based off of user reports. On the one hand there are reports of it feeling physically toxic, demotivating, anxiogenic, cognitively&emotionally blunting, loss of libido, etc. On the other there are people reporting it's anxiolytic, nootropic, motivating, mood-enhancing, improves bodily awareness, helps in meditation, and even mitigating schizophrenic symptoms. Other pros are that it generally seems to have an instant effect, the effects are pronounced/noticeable, and benefits are sustained with prolonged usage. Cons.. GABAergic agonist it would appear. May require cycling on/off. On paper however, it seems to hold great potential in general, and well worth the shot. I'm still up for giving this a spin, and I'll look in to buying it. Syntheso, would you mind mentioning your source? Lastly.. wonder how this would combine with Coluracetam. I'll try that myself when I do try the Nefi.

Glad it worked out that great for you! So I tried high dose Colu twice last week.. Well aside from the fact that I can't remember, there were also the confounding factors of Damiana, Skullcap, Catnip, Valerian, Ginkgo, Kratom, Marijuana, Cocaine, Alcohol, Oxazepam, Sleep-deprivation, and what not.... Yeah.. had a little "fuck-it" week. Going to have a "clean-up" week starting tomorrow, and I'll trial again after that in higher doses (the Coluracetam that is).

Awesome man, looking forward to hearing more of this! How would you compare it to any other racetams you've tried? I'm up for giving this a go too.

Ouch.. Wishing you a smooth recovery!

Thanks for the heads up. Did the aggravation persevere after cessation of SJW, or did they dissipate thereafter?

Californiaguy: Hey cool study, thanks! I'm about to start playing with SJW myself, see how that pans out. Seems like one of those things you need to take for at least a few weeks before effects become noticeable. I don't really remember what I was going to comment on the serotonin syndrome theory.. Basically the inducing drugs should cause for mass downregulation of 5HT receptor, universally when speaking of MDMA, selectively when speaking of LSD. Perhaps as a compensatory attempt the brain overproduces 5HT after this event, preventing subsequent upregulation? I've no literature to back that up; just a wild thought. I'd like to see more ideas on this; don't have much myself at the moment. On theory generally accepted to cause upregulation is indeed either long-term antagonism, or the lesser known process of short-term/intermittent agonism. I fear the process would be quite slow though, but indeed worth the investigation. One thing that might hinder this, is if the individual is stressed. How directly, I don't know, but I doubt it would be very beneficial. Perhaps as a reduction of visual symptoms this might help, but for other symptoms I'm not so sure.

Merry Sinemet day Chris.

I think it may depend on what SSRI in particular. Paxil for example has anticholinergic effects, albeit not as bad as Scopolamine for instance. Which are the most common SSRI's reported to have adverse effects? I did Prozac for a while, and I didn't experience any effects. Are you suggesting that HPPD may be a case of serotonin syndrome/too much serotonin? I have some thoughts on that which I'll try to add later. Funny; because I tried Tianeptine, which is a Selective Serotonin Reuptake Enhancer, and albeit not a fair trial, the first week I noticed some benefits such as anxiolysis. I quit after week 2 however, because I didn't notice any benefits past ~day 3-6 and wrote it off as placebo, plus I tend to be impatient and I was going to try something else. Hardly can this be seen as useful data though, considering the improper trial. By the way; Ketanserin seems better from an initial glance.

IMO drop the Tramadol and try the Gabapentin by itself.

Cheers Syntheso! Sam: I'd imagine it would be equally difficult if not more so to get Suboxone prescribed. Acquiring it is of course a different story, and it would be likely that if you can acquire Buprenorphine you can acquire Naltrexone as well. Indeed, dosage is something that would need to be worked out. I've seen some posts about it in one of the links I've mentioned, and as soon as I reread the thread I'll post a direct link here. Apparently with the correct ratio of Buprenorphine/Naltrexone dosage, tolerance can be avoided as well as addiction. Or so I've read in a glance. I'll post that too once I find it again. Yes I too believe this holds great potential Anyhow; I'm able to acquire all of the above, so I'll have to quit Keppra first. Also, I'm hoping that the process of acquiring JDtic will go faster than that of Coluracetam. In any case I'm definitely going to try it when possible, so I'll see how that goes. Depending on how long it'll take, I might not even bother with Naltrexone/Naloxone/Suboxone/Buprenorphine. Also, I think Nalmefene might take a while to be available here, so I presume JDtic will be available faster than that. I'll probably go commando when I do try the JDtic; not sure about interactions etc. Haven't even looked into the studies. Ohh.. I was going to type more but I typed this 2 hours ago so I forgot. I'll just press post.

You took the words right out of my mouth.. I feel like that every other day or so. None of the supplements/noots have been helping significantly then? Sorry to hear man.. I know it can be fucking hard. Just you know.. keep as positive as possible, and know that we're all working on finding a cure/treatment. Can't be much longer now 'till one is found, or so I like to think. Some people (divided over several forums) are on to something with KOR antagonism; seems to be ace for DP. And afaik 90% of us say that if only the DP/DR/Anxiety/Depression/Brainfog was gone, we could live with the visuals. Anyhow; good luck with your appointment!

Yes.

Thanks Andrew. Bummer about the Naloxone. Have you tried combining buprenorphine with naltrexone instead? What do you mean by 'white gf with extra pulp'? Anyway; as an update: I bought Perika SJW and Ginkgold Ginkgo. However it's unlikely that these will contain any amount of Amentoflavone. But I figured what the hey; worth a shot regardless of that. Also, for those interested, I've provided the following links that discuss the merits of Kappa Opioid Receptor Antagonism: Link 1 Link 2 And my own thread. And a thread over at DPselfhelp about Nalmefene. I've been thinking about trying Buprenorphine+Naltrexone, however I'd have to completely quit Levetiracetam before doing that. @@Syntheso KOR antagonism supports your idea of NMDA agonism, which would be a downstream effect of KOR antagonism.

Well I went ahead and ordered Perika SJW, along with Ginkgold Gingko Biloba, which are both supposedy the best of the best. Should be here in a few days, so I'll start with them when they arrive. And I'll try to adhere to a regimen for sake of evaluation. I'll post my experiences here.

Hmm.. apparently SJW may cause cataracts.. Well I guess using NAC eye drops could put that into balance.

Anyone have any experiences with Naltrexone? Or Naloxone, but I believe the latter is only available intravenously, hence I doubt anyone has tried this for the long-term. If you do have any experience with either of these, how did it help? Apparently Naloxone is pretty ace for DP, but of course comes with practical difficulties. An open trial of naltrexone in the treatment of depersonalization disorder. Effect of Naloxone therapy on depersonalization: a pilot study. Also Suboxone has been reported to help with DP/DR, but I haven't looked into that. What I'm interested in is "Amentoflavone", found in SJW and Ginkgo Biloba, which is an antagonist at the Kappa and Delta sites (not sure about the latter). No; this is not a hippie agenda, it's merely because Naltrexone, Naloxone, and Suboxone are particularly hard to get prescribed, thus Amentoflavone would be the easiest way to go. Anyway, you also might want to have a read through this post about Suboxone virtually curing DP. Though pure Amentoflavone is really expensive and hard to get, I'd thought that perhaps combining high-quality extracts of both SJW and Ginkgo Biloba may have a chance at helping.. Thinking about trying this out myself. I haven't ever tried SJW, so I thought it could be an interesting idea. As for Ginkgo; I've tried your average supermarket brand without any noticeable effects. Turns out that quality and brand really does matter, so it's worth giving another shot. Altogether that would be +/-$40 for a 20 day trial of both with the products I'm considering, so not ridiculously expensive. Input anyone?

Any updates on St. John's Wort? I was reading about opiod antagonism mitigating depersonalization, and found that Amentoflavone is a plant constituent found in Ginkgo Biloba and SJW, among others, that acts as an opiod antagonist, which I found quite interesting. I haven't given SJW a try myself, though now I'm considering it. Does anyone have any input? Cheers.

Just a comment on Tramadol: I tried it too.. I didn't notice much of an effect besides that I would 'dream' I had convulsions. I say dream because I don't know whether it happened for real. As I would drift off I would semi-awaken and experience what I can't describe other than convulsions. Then again, the stuff I had I ordered online and it may well have been bunk, but I did notice that effect. In any case it did nothing for my HPPD or other symptoms.

Congratulations Chris; hope it helps!

I've combined it with Choline Bitartrate twice I believe, but no; generally I don't take choline supplements.

Maybe we should all get our prostates removed? http://www.ncbi.nlm.nih.gov/pubmed/3377929 Just kidding, haha But Glycine levels do seem correlated with the VEP P2 component, however not with latency, or at least not in this study.

Ohh I see I never updated this one. Alright so the first day I ended up doing 100mg, or 10 gums, and it was quite nice. The second day I did 60mg, or 6 gums, and it started getting a bit.. spacey and lethargic. But I can't say this isn't due to the usual weirdness. Last night I had 3 gums, or 30mg, before bed, and I slept freaking amazing again. Before I fell asleep, I felt a several pleasant waves/rushes from my head down to my feet. Also some long lost memories past through my mind's eye, which was refreshing. Can't remember them as vividly now, but it was nice. Think I'm going to stick to using these at night though. In any case; I sure like the product.

Damn if I really can't sleep I go all the way with whatever I have: Damiana, Melatonin, 20-spices tea with honey lemon and milk, Magnesium, sometimes Passiflora.. Recently also CBD has been awesome for sleep, which I'll give another go tonight to confirm. I really just make do with whatever I have available. I know Kava was pretty awesome for sleep as well. Ashwagandha in particular I only take at night, but I've only taken it a few times. Though there comes a point where I wonder how it'll all interact, so usually I don't combine too many things. I still have this one product "Instant Tranquil-ability" with Mulungu, Wild Lettuce, California Poppy, and a bunch of other herbs that I haven't tried yet, for the reason that it has so many ingredients! But generally speaking I know nothing about histamine so I don't mess with it consciously.. Not sure if histamine drugs are the way to go for sleep, but what I've listed usually helps with sleep, some better than others, so perhaps give those a try

Ahh I see what you're getting at.. Yeah sometimes I too get that: Ohh shit it's too much. Waking up can take me anywhere up to an hour sometimes, just trying to adjust to being awake (and to the light). Dunno about goggles though.. would be quite uncomfortable. But a ceiling lamp above your bed that could do this, combined with closed curtains, may be an idea. Just the money.. ohh the money