VisualDude Posted December 13, 2018 Report Share Posted December 13, 2018 Wondering if anyone has experiences relating to neurosteroids ? Neurosteroids are just hormones and hormone metabolites that influence brain function. To illustrate: estradiol levels affect memory, testosterone enhances goal orientation and focus, the DHT metabolite 3α-Androstanediol is know to have "rewarding, anxiolytic, pro-sexual, and anticonvulsant effects" https://en.wikipedia.org/wiki/3α-Androstanediol The topic CAN be an IS complicated. Here is an excellent text regarding neurosteroids and seizures: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3728472/ . Of course its relevance here is that HPPD is a constant pre-seizure state and HPPD at times responds to GABA alterations and neurosteroids actually modulate and can activate GABA receptors but don't loose effectiveness such as taking a benzodiazapine does. I PROPOSE THAT THIS IS A KEY AREA OF RESEARCH THAT HAS NOT BE EXPLORED FOR HPPD. Certainly hormone manipulations, particularly DHT and DHT derivatives substantially help my visual issues and other issues. DHT is not only a "positive allostatic GABA modulator", it also has strong influence with D2 receptor function (a personal nemesis). This subfunction relates to reading social cues and I suspect may related to DP/DR. Now rather than make this complicated or get hung up regarding the technicalities of the subject, it comes down to does anyone notice effects from medication or changes in: Estrogen Testosterone DHT Progesterone DHEA Cortisol Oxitocin Finisteride Anastrozole The list is not exhaustive but these are major players. Here is a bigger list https://en.wikipedia.org/wiki/List_of_neurosteroids Thank you for your paticipation 2 Link to comment Share on other sites More sharing options...
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