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Everything posted by Onemorestep

  1. Before we get into the significance of this connection, we must first learn a little bit about what Levetiracetam and SV2A are. click (LINK) for links. Keppra In 1999, Levetiracetam (LEV—commercial name: Keppra©) was approved by the Food and Drug administration as a novel anti-epileptic drug. It is particularly useful in patients suffering from partial seizures, patients less responsive to conventional drugs or showing risks of drug interactions (Hovinga, 2001). Even if the exact mechanism by which LEV acts on seizures is still undefined (we don’t even known if LEV is an agoni
  2. I wonder if there’s a way to quickly get more vitamins in. (Sulbutiamine, magnesium threonate.?)
  3. I stand corrected--- Valerian is a bit more than just a natural benzo.... "Valeriana officinalis (Valerianaceae) has been of great interest for its therapeutic uses for treating mild nervous tension and temporary sleeping problems. In traditional European medicine it has been also reported as an antiinflammatory remedy. This study reports that the EtOAc extract of the underground parts of V. officinalis showed inhibitory activity against NF-kappaB at 100 microg/mL in the IL-6/Luc assay on HeLa cells and provided protection against excitotoxicity in primary brain cell cultures at micromola
  4. Psychedelics as a novel approach to treating autoimmune conditions Definitely worth a read. Glad science is finally getting off it’s ass.... lots of interesting stuff in here that can tie to your thoughts Fawk
  5. https://www.pnas.org/content/115/36/9002 IL-18 deficiency—>increased neuronal activity—>reversed by levetiracetam. hallucinogens/ssri’s/cannabis/antibiotics —> alterations in neural immune system—> increased neuronal activity??
  6. I have used it once at a very low dose and didn’t notice anything. But I was also smoking a bunch of weed at the time hehe... hmm never feeling awake? I would do a little research first but it would be very interesting to see if you react well to a dose of prednisone. I’ve been wondering if acute stage hppd could be neuro inflammatory/neuro immune. But it’s really just a theory. Been wondering about the connection between cannabinoids and encephalopathy which does exist. I would try what your doctor gave you first, of course I’m sure it feels kinda scary to try something
  7. https://pubmed.ncbi.nlm.nih.gov/10998193/ https://scholar.google.com/scholar?q=experimental+autoimmune+encephalitis&hl=en&as_sdt=0&as_vis=1&oi=scholart#d=gs_qabs&u=%23p%3DZk7M4-de-goJ
  8. You know interestingly enough there is mounting evidence that epilepsy, schizophrenia, migraines are all immune system related. It really does make sense that hppd could be as well. in fact, I think neural immune system issues can account for everything you mentioned in terms of mitochondria, astrocytes, etc. You may find this interesting: https://www.google.com/amp/s/www.psypost.org/2021/01/psilocybin-produces-an-immunology-related-genetic-response-in-the-prefrontal-cortex-of-pig-brains-59115/amp might be worth looking into. you also might f
  9. Metformin inhibits mitochondrial ROS. Wanted to throw that in here before I forgot.
  10. Yea I wouldn’t risk it for a very long time if ever. I do think you can have brain specific areas of hppd. Most of the people on this website have emotional anxiety symptoms. Many of the people on Reddit are just enjoying constant visuals and a dreamy headspace (lucky bastards). at the end of the day, we don’t know what causes this but we do know it’s volatile as all fuck and a single dose of a drug can have hppd onset upwards of 6 MONTHS later. Wild right? Just read a case of doctor prescribed ketamine induced hppd for a teenager that got it that long after. bu
  11. Hi Ruskin! people absolutely do heal. Abstaining from any psychoactive drug will certainly help your chances. So sorry to hear you are going through this. just remember—this isn’t your fault. Many people smoke a little pot. There’s no way you could have expected this. Go easy on yourself :). its very easy to get sucked into your condition when it’s new. Give it time and do whatever you need to help you pass the time.
  12. https://www.google.com/amp/s/www.psypost.org/2021/01/psilocybin-produces-an-immunology-related-genetic-response-in-the-prefrontal-cortex-of-pig-brains-59115/amp
  13. Hi Hall! if part of the etiology of hppd does indeed lie in the loss of gaba inter neurons, resulting in a loss of the “break pedal” and then subsequent glutamate storm—then taking lamictal would help creat an artificial break pedal. It’s a Bandaid... but bandaids are good! They help you heal. And they help prevent you from opening up the wound. hppd has cascade effects for some, it seems. Usually there is initial onset, and then a series of events that take place later (for some). Some people report a see-sawing effect. Some report a worsening after the first, second, or third
  14. Keppra inhibits cd8 T cells I have shit tons of immune system issues. They just keep accumulating too.
  15. The first time I got it I didn’t realize I had it, tbh. Symptoms subsided within 6 months if I remember correctly. yymv but I was using harder drugs than you and I imagine that is in your favor. Some symptoms may take longer to go away than others. Don’t assume one is linked to the other. Different brain regions, different rates of recovery time, different symptoms etc. Most of my visuals have subsided in intensity over the years. Some aspects of them gone. I did a LOT OF DRUG man so don’t sweat it. If mine got better you’re will absolutely get better. You’re on the right track. Man
  16. After having Epstein Barr enter my brain recently and cause a lot of crazy symptoms I associate with hppd, I’m seriously wondering about possible viral components to this disorder. 95% of people have this virus in them. It can resurface, albeit its “rare” (I’ve had it twice last 4 years... last time I thought I was losing my mind but the doctor didn’t inform me. I simply found out via blood tests.) Psychedelics influence the immune system/would make it easier for latent https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4500993/ EBV can cause hallucin
  17. I believe in time you will heal on your own a few people on here (myself included) reaaaallly pushed the envelope. It’s a slippery slope and no one here really knows what happened unfortunately. ssris gave me a lot of weird physical anxiety in my abdominal area. It was highly distracting and a huge relief when I came off them and it disappeared. But I would say if you feel better on them, it’s not going to change much. first time I got hppd I was on ssris and it was better on them than off. When I got hppd BAD that’s when I couldn’t tolerate them anymore. Kinda forgot ab
  18. Did you end up taking it? Doesn’t seem like many people here have. I imagine it’s safe just by it’s moa and in fact there’s some cool stuff about occipital lobe gaba increase with it. it might make you feel dumb af; be prepared.
  19. Hey hall! the time line is very person specific. I would say you are lucky and you’re a is most likely less severe. But who knows! stay away from the benzos. They feel like the only thing that helps in these situations but they are terrible foe your brain. I’m sorry that you feel so bad but daily benzo use will come back to haunt you. I still have ptsd from withdrawal from them... it is best if you can do without drugs at all, but if you absolutely must take a gaba drug gabapentin is better than benzos. You’re body will be the best tool you have to hea
  20. So sorry to hear this jay is right—off all those medications. It’s very hard to learn individually what helps and hurts with meds with this but the rule of thumb for 99% of people is—no antipsychotics and no SSRIs. Don’t screw with serotonin. Do not take anticholinergics. Do not take any recreational drugs LIKE NONE. If you’re going to try a medication, gabapentin may be of some relief to you. It is easier to stop than benzodiazepine drugs and has less dependency issues after stopping it. A member of this website, Visual, felt that gabapentin stopped the worsening of the p
  21. Its always interesting to find out something new in regards to medications that have "cured" people of HPPD (sadly not everyone ) "Epilepsy is a neurological seizure disorder that affects over 100 million people worldwide. Levetiracetam, either alone, as monotherapy, or as adjunctive treatment, is widely used to control certain types of seizures. Despite its increasing popularity as a relatively safe and effective anti-convulsive treatment option, its mechanism(s) of action are poorly understood. Studies have suggested neuronal, glial, and immune mechanisms of action. Understandin
  22. hello everyone! I recently learned I have a very acute re-occurrence of Epstein Barr. It is causing a variety of mental symptoms not dissimilar to hppd but lacking 99% of the visuals. I thought someone here might find this interesting I know somewhere on this forum is conversation about hppd and viruses but for the life of me I can’t remember where (like my shoes of late...) for real though.... it’s hell. I’ve been having panic attacks that are SUPER strong. Stronger than anything I’ve had before. My only hope is I can stave it off from my body eventually. In the meantime
  23. Afaik taurine is not an upper and is used in conjunction with caffeine to make it smoother because it provides inhibitory action. That doesn’t negate your bad reaction—ppl with hppd can react all sorts of funny ways.
  24. In the world of hppd, I think almost anything is possible symptoms wise hahah. I mean, if someone had just a few visual symptoms, would they even find there way here like you? Usually people come here because they are freaking the fuck out. I know I didn’t come here when my symptoms were primarily just visual weird things. I hadn’t even heard of hppd until about two years into really having it bad. what you see and how you notice things is a very interesting science. I didn’t realize I wasn’t seeing colors saturated properly until I took NSI-189. But I didn’t know... until I knew. Co
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