onedayillsailagain

Syntheso! That pun made my day haha! No worries, take your time with responding. And holy cow! I totally overlooked that Calcium link with Piracetam! Thanks times a thousand, great find! If I wasn't so hungover, I would have a more literate response to this. I'll definitely spend some time on this once I'm feeling better. Again, awesome contribution! Piracetam is very dose sensitive in its effects, so perhaps it just might work for you at that dose! Haven't tried it at that dose myself. Thank you thank you thank you!

Ok bear with me on the lack of creativity in the title, I'm having a hangover. Nonetheless, I figured instead of posting a new topic for every single study, I'll cram a few studies into one topic. Now I think there's a general consensus that migraine, epilepsy, etc. are cross-referencable to HPPD's pathogenesis. Please correct me if I'm wrong. Open label trial of coenzyme Q10 as a migraine preventive Source source: Coenzyme Q10 deficiency in adolescent migraine [PDF] Some people believe that gene alterations can lie at the core of HPPD's pathogenesis, so this one's for you epigenetic fans!: source: Disease-specific alterations in frontal cortex brain proteins in schizophrenia, bipolar disorder, and MDD [PDF] I have no clue how to go about interpreting the above statement, so if anyone can comment on the possible significance, feel free Time for some epilepsy relations: source: Life Extension I know, it's an indirect source... I'll fix that later. I'm just really tired. I think I'm gonna lie down and dig up a little more on this later, this isn't going all too efficient. Voila: source

Well so far so good. Had a foot bath with 1/2 cup Mg to 10L water. Afterwards I ingested 1G of Mg Malate powder (containing 150mg Mg), a few hours later another gram. Anyway, I just went grocery shopping. For some reason I tend to get anxious in grocery stores since HPPD came along. I must say, I noticed a siginificant reduction in anxiety. Normally I'll twitch, which in turn makes me more anxious.. you get the point. This time only some slight sweating, and my speech was clearer. But hey, could be placebo. I'll continue Mg untill Monday, to better discern effects. Up to now, I can say I feel naturally more relaxed. Many other supplements I have tried usually come with a strange feel to it, but this just feels natural. Honestly I've been quite relaxed today. Anyway, after dinner (Mackerel for the PS and Omega's!) I'll take 3 grams of the stuff, and see what happens. The patterns on my wallpaper (which I tend to use as a HPPD-meter) are distinguishable today, but that has been so all day. Probably the wine I had yesterday contributed to that. Or not. Lately I've been so focused on seeing what substance has what effect, that I have forgotten that some things can also be of natural cause, or just by randomness. I'll update tonight if anything significant happens. So far no laxative effects (hurrah). EDIT: Well.. Alcohol just ruined all chances of giving an objective view of the effects of Magnesium. I guess I'll digress.

jay: Well that's good! At least it wasn't due to adverse effects. Visual: I haven't had a fever (let alone been sick) since I've come to acquire HPPD, so I wouldn't know the effects on me personally. I know Mg and B6 are essential for DA synthesis, so that just strengthens the fact that it'll have benefits. Haven't found any particularly interesting studies on that, but I might do a more thorough search later. I only mentioned the VEP thing because it seemed highly significant.. Still don't know what to make of it though. According to some studies, more than 70% of the population is Mg deficient: “Dietary Magnesium and C-reactive Protein Levels,” Journal of the American College of Nutrition, Vol. 24, No. 3, 166-171 (2005). Jaffe R MD. “How to Know if You are Magnesium Deficient: 75% of Americans Are” (transcript), 06/16/05, www.innovativehealing.com Anyway, I just received the Mg supplements in the mail. Ohh and regarding Citrate vs. Malate: SOURCE Now sadly he doesn't link much studies on Mg, but the guy is pretty darn good at what he does, so I trust it. I'm sure it's verifiable. So... time to have a foot-bath! I don't know whether I should start oral dosing yet.. 6,25 grams seems to be preferable for that goal. However, considering the whole probably-will-be-getting-Keppra-soon thing, I'd rather wait to get Keppra, and then add Mg. I'll think about it a little. I'll make an update if anything significant happens.

Hey bpl, long time! Good to read of your profound experience with St. John's Wort! It does seem to enhance DA signalling in the Thalamus, among other things. from Wiki However, it has also shown to disrupt PPI. This makes the therapeutic potential in HPPD somewhat controversial. But perhaps that effect is dose-dependant. St. John's Wort, however, works in many different ways, and if your personal HPPD pathogenesis is seretonergically involved, then indeed it could definitely help. Either way, what the heck, you're feeling better, and that's what matters most! Are you able to do most of the things you used to? Anyway, hope the benefits will remain sustainable and even accrue for you! Thanks for dropping by and letting us know.

GLYX-13! NMDA modulation is currently one of the most novel anti-depressant approaches I believe? I got kind of pissed off when I read in the Dutch news today about Ketamine being a "novel" anti-depressant. That's been known for ages. Anyways, I remember looking it up, and it was like $100/mg, and the dose was 1mg/kg I believe. Could be wrong slightly, but you get the point.

[PDF] Furthermore, [PDF] HYPEREXCITABILITY OF OCCIPITAL CORTEX IN MIGRAINE Is currently unavailable, but has a subsection named: Selective occipital cortex magnesium Mg 2+deficiency reduction in familial hemiplegic migraine may reflect an ion channel disorder. Come on! Selective occipital cortex magnesium deficiency and familial hemiplegic migraines? Awesome! Too bad it's not available from any source. To quote wiki: FHM signs overlap significantly with those of migraine with aura. And also convulsions can be a symptom. Ok perhaps I'm a bit over-excited (haha, get it?) but I'd love to be able to acces this study.

[PDF]

More Magnesium goodness: source Now I kind of forgot to do my homework on VEP's (read: no clue what they are, just know they are relevant). But reading from the EEG HPPD study, it says that HPPD was charactarized by shortened latency of the P2 component of the VEP. This seems paradoxical... Any comments? Maybe higher amplitude somehow means shortened latency? No clue personally.

I believe you're referring to Threonate? Could be wrong though. ScienceGuy's thread on Anxiety Treatment covers Mg as well. Anyway here's a study portraying the anti-convulsant effects of Magnesium compared to Diazepam in Eclampsia. source Anyway, seeing as Epsom Salts are €10 for 85 grams, I'll order some in a moment. If I order in the next 75 minutes, I'll have it by tomorrow. Despite not having a bath, I do have a decently large tub like thing. I could take a footbath with some Epsom. I have a Ca-Mg-Zinc supplement, but it only contains 130mgs of Mg Oxide, and I've never taken more than 1 of those. If we take Jay's case as a rough estimate, 750mgs is required. I'm gonna see what the comparable transdermal suggested dosages are. Here's some more Mg info: source Malate seems to be the preferred oral form, and seems to work synergistically with transdermal Mg Sulphate. Instead of ordering online, I'll go check if the stuff is available at the Health Shop around the corner. UPDATE: Ended up buying 1kg of Magnesium Sulphate, and 100grams of Magnesium Malate, for €26 online, free shipping. Pretty good deal.. Should be in by tomorrow, curious to whether the Epsom bath will have instant effects. In the meantime I'll study a little more into oral dosing safety and interactions.

Ahh thanks for linking that thread. And you needn't be anxious for anxiolysis I suppose! But I get the picture; no effects. I think there's like 5 different oral forms of Magnesium available.. I know, maybe it's nitpickery, but you never know right? It could maybe just make that subtle difference. I wonder if 's initial succes remained sustainable? What jay describes, is more or less my experience with Melatonin : visuals are still there, but they seem to be finer and not so "in your face". I'll remember this as a potential adjunct for later down the road.

Yeah I remember it being flaky like that. Dotarizine seems interesting because it antagonizes 5-HT2A in addition. Brivaracetam! That's the name. Remember it somehow now. I can see why it is interesting. Have a look at this: source I presume you already read this. Wonder when it will be available? Also of interest: source Brivaracetam appears to inhibit Na+ channels. So now aside from CCB's, SCB's also show promise for treatment potential in HPPD. This might've been known/speculated already.. but to me this is all still an exponentially growing discovery of the mysteries of neurology.

If youre looking to make pictures, I suggest trying out Paint.NET It's free and pretty diverse in its abilities. When your list is finished, perhaps I can have a go at making these. Allthough those skills are also largely lost, it wouldn't hurt to try.

Wow thanks for the extensive reply Visual! I considered Epsom Salts.. But I don't have a bathtub. And oral magnesium was on the candidate list for a while, but you know, unemployment financial priorities and the like. And thank you for the caution, but I always do make sure to educate myself sufficiently before conducting my experiments. I remember someone inquiring about calcium supplementation.. I guess we can now conclude that that wouldn't be a great idea? Anyways, as with many of my theories.. I never really dive into them too deep (cognition blabla). I just post them here, so that I (and others) can use them as a basis for further theorization later. This reminds me, I should make a back-up. Ahh.. now another thing pops into my head! Ever since I've had HPPD, I developed postural hypotension. For the past months I've been adding decently large amounts of salt to my diet, and almost never have any postural hypotension anymore. I don't know if postural hypotension is considered a visceral condition, but thought I might mention it anyway. I'd hate to add anything more really, seeing as my knowledge on all this is very limited. Frustrating, because I always used to ace biology class. Feel free to continue discussion here though Ghormeh: interesting.. Perhaps it's a dose-related thing. Did you experience anything else (anxiolysis)? Also, this might be highly far-fetched, but perhaps with the growing research plausibly supporting supplements in their potential to mitigate HPPD symptoms.. Maybe with further research, a specialized stack/regimen could be conceived?

Flunarizine does indeed prove unsafe. If I remember correctly (I'm lying, I actually have this in my notebook), it is linked to early onset Parkinson's? Could you provide a referance to this Keppra 2.0? Dotarizine crosses my mind, but that isn't a racetam. Regarding pursuing a career in Neuroscience, I myself would also like to do so, once my cognitive functions are back in play. That said, I still have high school to finish. If by some miracle I do manage to function on the same cognitive level previous to HPPD, aside from being ever grateful, I'd feel obliged to use it to research HPPD, and find a cure. There's only so much I can contribute in this state. Hey who knows, perhaps in a decade we'll all be in a lab researching HPPD together? Hopefully future treatment will be less invasive than cutting out bits of the occipital lobe/visual cortex! Epigenetics and NIBS seem the most promising so far. Curious to read the findings of Gosby and Schankin. The awareness is defnitely helping, though I don't know what the impact is on the scientific community. At the very least, it is helping the cause of prevention. There's a very popular Dutch talkshow about drugs, and it crossed my mind to (in a far future) contact them to see whether they're interested in having me over for a talk. They already had a guy over with cognitive deficits from XTC. Anyways kind of forgot where I was going with this, so I'll cease the rambling

Some more info on GJB's. Gap Junction Wiki Electrical Synapse Wiki

source Though this was worth posting.

I'm curious to know what you're working on! Maybe I can help? Yes personally I believe Melatonin is very dose sensitive. Tonight I slept great again with just 2,5mgs, no nightmary flashes. Visuals are improved today, and my wallpaper once more has a distinguishable pattern, as opposed to a sea of vagueness. That said, other symptoms are still present. Melatonin helps, but marginally. Perhaps I'll try some Sulbutiamine later, to see if it helps with the "next day tiredness".

It's not really as if there are "established" treatments, but indeed those Jay summed up are pretty popular. Other things to discuss with your doctor can be Clonidine, Lamotrigine, and Flunarizine. SSRI's have been used throughout literature, and some people benefit from them (e.g. Venlaxafine). If you're talking research wise.. I don't know whether there's any active research at the moment. There have been reports of NIBS helping people (including myself). There's a plethora of supplements available, and many people seem to find nootropic adjuncts very helpful (Kava etc.). One stack to raise PFC DA could be L-tyrosine+Bacopa Monnieri extract+EGCG+Quercetin and maybe L-theanine for some striatal DA action. This is just an example. Honestly I think the majority of treating your HPPD will involve doing research yourself. I mean look at what Jay's doing: Buspar is not usually considered when treating HPPD, but it could very well help his anxiety, which in some could help with DP/DR. Hell you'd be surprised at the many medications and supplements people have tried here. I myself have tried over 50 things. So to answer your question: no, I don't think so. Maybe in the next few years. Who knows. A lot of members here also seem determined to find a new treatment/cure, and many actively devote their time to studying neuroscience, be it professionally or at home. I suspect within the next decade there'll be at least one new treatment.

@zukov What's your experience?

I concur, epigenetics would be a promising research target. Sadly, it is far beyond my current comprehension. Now I vaguely remember reading an entire article on how the erosion of Telomeres in DNA caused by chronic stress, were shown to be reversed and restored by initiating a healthy lifestyle with little stress (read: naturally induced indirect gene therapy). Man I wish I could find that article, it was quite amazing, and very elaborate. But perhaps if someone here is motivated, they could find it. And suddenly I remember a documentary "The 7-year old surgeon" about this kid who believes he could one day cure cancer with an oral epigenetic treatment. But anyway, any updates on epigenetic theories?

Ohh.. Well in that case I suppose you could contact him personally. I think I remember reading somewhere that he's still providing it as an option or something.. foggy mind Honestly with these initial results released, I don't see why anyone would bother continuing research into Tolcapone+Sinemet, as it is highly unsustainable. The initial results were very helpful, providing us with insights to the pathogenesis of HPPD, but largely stops there. Basically it has confirmed that enhancing PFC DA signalling mitigates sensory gating deficits we think are involved in HPPD. With great thanks to Dr A., we can now continue to apply this model in more sustainable treatments. Personally I believe the more promising research would lie in NIBS, and would love to see a study conducted with HD-tDCS. Ah well, beggars can't be choosers, right?

source Thought it was worth posting, as some people believe HPPD is a (strange) form of PTSD, or experience PTSD symtpoms concurrently.

Source Now have a look at the HPPD EEG study: Source I found this too be highly notable, as this shows us why Levetiracetam in particular has high efficacy in treating HPPD. So perhaps its effects are not only due to calcium channel inhibition. This can provide us a new model for treatment research: antagonizing neuronal hypersynchronization.