onedayillsailagain

Visual, with all due respect.. If these heat-shock proteins somehow contributed to long term genetic and/or cellular alterations and/or lowered ability to repair these, wouldn't it then be substantially contributing to a possible cure so as to mitigate these? What I mean is implementing substances that aid in the repair of DNA/RNA and cellular structures. My knowledge on this biological level is limited, but take for instance Resveratrol, that has shown to aid in the biogenesis of mitochondria in the visual cortex. Then again, the possibility of genetic and cellular alteration has been around for a while, correct? If I'm not mistaken, many substances have shown to posses such qualities. If heat-shock proteins are able to reveal the (exact) mechanisms by which alterations have occurred at that level, then specific substances can be introduced to improve these, no? In other words; indeed it might only pertain to getting HPPD in the first place, but at the same time indirectly allow for acquiring more specific knowledge to ultimately aid in applying more focal cures/treatments. Anyways, still haven't gone through all this, so forgive me for any inconsistencies/nonsense in these thoughts.

So here's a quick update on my situation: Monday I'll be contacting my doctor, to see whether I have been referred to the Neurologist. Hopefully things will go swift, and I'll be able to get tests done that very week. I've inquired about the full Casa/Bosio article, and it is currently being dealt with. I'll see what I can do about obtaining and sharing it, with copyright nonsense and all that. Ghormeh: I'll be receiving the questionnaire for HPPD symptoms shortly, and will translate it for you a.s.a.p.

Syntheso: Ahh I'm so happy for you! That's great! Yes I am indeed conducting more or less the same trial, albeit solely with Keppra. Are you getting qEEG's and VEP's as well? It would be great if there were 2 "case reports" succeeding each other! Two different doctors, countries and methods! Well I guess there's no urgency in researching supplementation now. However it would provide for possible future augmentation should the initial effects somewhat come short of needs. I'm doing good! Weather is nice, and I'll be seeing a Neurologist shortly to get my tests done. I'll know more by Monday. I've just been watching TV shows to keep my mind occupied. Also I've given research a rest for a while; endless hours behind my laptop resulted in a minor back injury. Anyways, glad to see you've found someone who's so willing to help you. I look forward to your updates. I'll be making a separate thread/log once my own trial commences. Cheers!

Merkan: Thanks for adding that Syntheso: How's the homework coming along? Hehe. Yes if one can remember the trip, it can definitely be an eye opener. And I'm all too familiar with wishy washy explanations.. I'm curious to hear of your further experience with Piracetam! B complexes usually contain Choline indeed, however the dose is negligible. I'm sure there's some more info regarding Choline supplementation with Piracetam over at Longecity Generally speaking, it is advised to add some decent amounts of Choline. One can also eat extra eggs. Anyways, I'm tired so I'm keeping this one short. Let us know how things are going

Sometimes I'll look at something for a split second, and it'll produce a rather transient not so in-your-face after image. Other times I'll look longer and more focal, and it'll last for a minute or longer, especially with this checkerboard. WARNING: it's pretty trippy. The other day I was thinking about YouTube, about the "Play again" button. It just appeared on the wall. That was the first time that happened to me. An afterimage without an actual image. I think that's what makes HPPD so hard for me, is the fluctuating borders between thought, sensory perception, and the outer world that makes me feel like I'm constantly on the verge of a psychosis. It just feels like I'm lagging about 10 seconds behind everyone/everything else. Especially when I'm talking to someone, look away, and still see the expression they made 5 seconds ago whilst they are talking about something else. These are more mind-pictures than actual visual images though, but peoples' heads can briefly be seen when looking away sometimes as well. So to answer your question: Yes. Images can be both positive or negative, or fluctuate between them.

It's on the to-do By the way, here's an online GIF animator I found recently. Might help in creating pictures. It's a pretty good one compared to most.

No problem! Anytime!

Sounds great Ghormeh! Guess we have a proper distribution of workload going on here, hehe I look forward to completing your survey. If you like.. The specialist had a standard HPPD questionnaire.. I could ask to receive a copy and translate it to English for you, so as to have a reference for your work. Let me know what you think.

So sorry to hear that! Most likely the 3 weeks will be enough for things to clear up, at least a little. However, perhaps you can try tweaking your doses of the supps your taking. Have another search on Theanine.. Try upping the dose to twice 200mg a day. Maintain all your healthy habits despite this setback. If your feeling anxious, you could consider adding an anxiolytic (e.g. Ashwagandha) for a short period (up to a month). Just explain to your family what has happened if they question what's up. Maybe cut back on the Melatonin, as it can cause some strange dreams sometimes. Let us know how it goes, and good luck

Yes DA antagonism is why I advised not to use Mirtazapine earlier today. Let me look in my notebook.. Nope, haven't spent much time studying 5-HT. Other than pointing you to the Wiki, I'll keep an eye out for you. Interested in prospective treatments? I've got some new findings on VEP P2 latencies linking to cholinergic mechanisms, and possibly more evidence (in the same topic) as to how Coluracetam could improve P2 latencies, ultimately reducing visual distortions. I'd appreciate your ideas Ghormeh!

source: Applied Neuroscience[PDF] So.. Let's see what we can grasp from this. A delayed P2 component can be produced by cholinergic suppression. For the time being, I do not know whether a delayed P2 component is an interchangable term with shortened P2 latency. But IF it is, then this shows us a remarkable new approach to improving the sensory gating deficits characterizing HPPD (read: Improve HPPD symptoms). Thinking back to my findings on Coluracetam.... Coluracetam's cholinergic mechanism is that of a Choline Reuptake Enhancer, unique in its kind. It is not strange then to find that Coluracetam has been reported to have such profound on visual acuity. I find this highly exciting. If you're interested, there are many referances in the link provided above. Also, you can have a look at my findings on Coluracetam. Later I'll be adding my findings on Aniracetam, which has shown to improve visual hallucinations in Parkinson's patients among others. Please feel free to add your thoughts on any of this. Update: additional information. source: Changes in the human visual evoked potential caused by the anticholinergic agent hyoscine hydrobromide: comparison with results in Alzheimer's disease [PDF] An anticholinergic agent is a substance that blocks the neurotransmitter acetylcholine in the central and the peripheral nervous system. Coluracetam enhances high-affinity choline uptake (HACU) which is the rate-limiting step of acetylcholine (ACh) synthesis, and is the only known choline uptake enhancer to currently exist. Studies have shown Coluracetam to improve learning impairment on a single oral dose given to rats which have been exposed to cholinergic neurotoxins. Subsequent studies have shown that it may induce long-lasting procognitive effects by changing the choline transporter regulation system.[6] Both from wikipedia. source Whether or not my theory above is accurate, it doesn't really matter. If a delay in P2 means a lengthened latency, then perhaps one could coordinate research to cover acetylcholine excess. And even if it doesn't mean the latency, then either way the acetylcholine link is well worth time spent studying for future hypotheses. Update: Finally something to expand on the comprehension of VEP's. source: Neuro-opthamology page 46 (google ebook link) From the bolded sentence, we can conclude that a delayed VEP directly correlates to latency. Thus the question is: Is a delayed VEP response a shortened latency? Delayed means it takes longer time to process. Latency (from wiki) is a measure of time delay. If a shortened latency means that it takes less time to process, then a delayed VEP would mean the opposite. And then one could conclude that acetylcholine deficits produce a lengthened latency... And thus one could think that excess acetylcholine might produce a shortened latency... Ultimately arriving to the conclusion that a acetylcholine inhibitor might improve the shortened latency in HPPD.. It just seems to inconcrete to think of it that way. It would make so much more sense that an acetylcholine deficit causes shortened latency, and acetylcholine enhancement would mitigate that. But I could be very off either of these conjectures. Aaaargh! Admittedly my English isn't the best, combine this with my cognition. Any help on this would be greatly appreciated!!!

Common side effects of mirtazapine include dizziness, blurred vision, sedation, somnolence, malaise, increased appetite, weight gain (as a result of increased appetite), dry mouth, constipation, and joint and muscle pain. Less common side effects that tend to occur more often at higher doses include restlessness, irritability, aggression, apathy, anhedonia, difficulty swallowing, shallow breathing, decreased body temperature, pupil constriction, nocturnal emissions, spontaneous orgasms, impaired balance, restless legs syndrome, and vivid dreams. Rare and potentially serious adverse reactions of mirtazapine include allergic reaction, edema, fainting, seizures, bone marrow suppression, myelodysplasia, and agranulocytosis. Mirtazapine is an antagonist/inverse agonist at the following receptors: 5-HT1A receptor (Ki = 18 nM; IC50 = 1,000 nM) 5-HT2A receptor (Ki = 69 nM) 5-HT2B receptor (Ki = ? (~20-fold lower than for 5-HT2A/5-HT2C)) 5-HT2C receptor (Ki = 39 nM) (note: which could provide possible relief) Dopamine D1 receptor (Ki = 4,167 nM) Dopamine D2 receptor (Ki = 1,460 nM) Dopamine D3 receptor (Ki = 5,723 nM) Dopamine D4 receptor (Ki = 25 nM) (note: DA antagonism is generally wished to be avoided at all costs. However, Haloperidol has been used succesfully in treating HPPD. Conversely, Risperidone has reported to worsen HPPD. Curiously, it's pharmacology is eerily similar to Mirtazapine's) So with that pointed out.. Perhaps you can tell us what your primary problems are. Then we can do our best to give our (unprofessional) advise on what to discuss with you doctor. I agree with Ghormeh, in that Bupropion would be a safer choice. My view is that because of its more limited effects (focal modulation of specific mechanisms), it'll be useful to pinpoint exactly what mechanisms might be contributing to your troubles, judging by the effects. I think Mirtazapine is a pharmacological nightmare in it's widespread modulation. Again; discuss with your doctor prior to commencing any medicines.

Haha jay, that's a tad worse. Here's a vid from the YouTube Comedy Week I found quite funny:

Yes the DSM is disappointingly flawed in many ways. I'll see what I can do about the full article. I'll propose intercollegiate contact with Bosio/Casa.

So I figured I'd start my day with the easy stuff. Below is the translation I made. Dutch is a bit iffy regarding contextual portrayal (don't know how else to name it) so some of the stuff I translated literally to be more precise. Reporter: "Every year 1,5 million drug users report themselves at the website. Asking a question about your complaint there, is of course safe." Gerard: "But sometimes digital contact is insufficient, and you have to be treated face to face." Reporter: "The house doctor (General Practitioner I believe?) only has a few minutes, and does not always know the latest (note: scientific is implied) discoveries. That's why Gerard is expecting dozens of people per week, as of Friday, at the Partydrugs Conversation Hours. He comes across all party drugs." Gerard: "The most popular party drugs at the moment are: Aside from XTC, also GHB (note: Gamma-HydroxyButiric Acid), Cannabis, Alcohol and Mushrooms." Reporter: "And what are now the most prevalent complaints?" Gerard: "Well, the most complaints do indeed come from XTC (note: the Dutch "toch" means right or indeed, but can be thrown in to imply "as you would think/expect" without saying those exact words, leaning more towards the indeed meaning). In the form of hearing things that aren't there, mood disorders can unfold; really depressive complaints. And they can also include flashes of light, but also as if they're watching through a screen full of snow; a television screen full of snow. (note: He only had a few minutes, he did his best to quickly explain VS). A typical symptom of a damaged brain actually." Reporter: "The users that come to the Conversation Hours are usually not yet addicted. But inject or swallow regularly nonetheless." Gerard: "Those people I then advise to quit. And I can help them to get rid of there symptoms quicker, with conversations, but also with anti-depressants; prescribing medication." Reporter: "And should everyone then just quit drugs?" Gerard: "No, not everyone needs to quit. But you should if you're experiencing problems from it." So just my thoughts on this: This was uploaded in 2008. This is when he first opened the Hours for the public. Obviously any statements made in this show are subject to change and re-evaluation, as his knowledge has expanded through the years. Don't take offense by the "damaged brain" bit. Damaged does not mean broken or irreparable. The interview is rather short, and hence I think in the little time he was given he did quite a good job. Anyway, there's a Dutch talk-show I spoke of earlier. I'm going to take the time this week to see whether there's something about HPPD in their video archives. I believe there wasn't, but I'll check again.

Visual, thank you for your elaborate response. First I'll adress the last bit. I agree, heavy drinking is indeed unwise. I'm aware of my sometimes contradicting statements on alcohol. Hence I will try not to elaborate too much on it. Next time I'll celebrate with oysters. Moreover (maybe more importantly) it indeed does not allow for effective evaluation. This is why as of today, I am completely (aside from tobacco) supplement and drug (and tDCS for that matter) free for the entire course of scanning and medication. I don't expect this to be an issue, as I don't ever crave alcohol, and I know this will serve a (higher) purpose other than my personal health. Tomorrow I will be doing the Cambridge DP survey, and again a day before starting Keppra. Perhaps I will extend the washout period with a week, to be absolutely certain of parameters. Just for fun, I'd like to get a complete blood panel done before and after. I'll try to maintain somewhat the same sedentary lifestyle to not allow for sudden changes by exercise/endorphin spikes. However, in the case that I do actually start to feel better, I might (most likely will not) not adhere to that latter statement. Regarding your own experience with Keppra: if you felt sick at that dose, it is likely you were somewhat allergic to it. Hence it's not strange that you have marginal improvements. Have you tried other anticonvulsants? Lamotrigine seems to be the next choice.. Personally I rather not take it, for there have been some severe cognitive side effects reported. That said, you've experienced those with Keppra as well. Could you tell me what CEV's are? I see this abbreviation a lot, but haven't been able to find out what it stands for. Anyway, I figured I might as well point out that the Keppra study is available for download (internal link) Regarding flashbacks... Last night I had a flashback/nightmare. I rarely have these (once a month perhaps, if I'm very unlucky.. I've had <10 so far), so I'm not that bothered by them. Thankfully, because they're extremely anxiety inducing. Suffice to say, I slept pretty horrible. I think staying up late contributed to this. This is my secondary reason for why as of now I will do my utmost best to have a healthy, steady sleeping rhythm. Primary will be to try and keep my lifestyle as steady as possible, minimizing variables of outcome. Anyway, just to say.. How in the hell did anyone ever confuse this? A flashback is when there's a flash, back. Alas someone in history overlooked this. It would indeed be beneficial to come to acquire the full article. Perhaps it's possible to buy that specific journal on eBay or something? I'll bring this up next time I speak with the specialist. Ghormeh: where did you buy the article? Straight at the Journal of Neurological Sciences' website? I will also begin with a low dose. If no adverse effects occur, it'll be 2 x 125mg (+1 week) 1 x 250 & 1 x 125 (+1 week) 2 x 250 (+2 weeks) re-evaluation. If any adverse effects occur, vitamin B supplementation will be mutually considered. Goal is of course to find an effective dose. Some people have reported having experienced substantial improvement with low doses. Lowest reported is 50mg with 70% improvement of symptoms I believe. Yes, I believe the dosing schedule can be an important factor.. I think Rene reported that a larger dose at night made things easier, but don't quote me on that. Visual, how would you describe the improvements with DR? Because I find there's a difference between feeling less DR/DP'd out and feeling more like yourself.

Personally I find a little bit of humor makes my day much better at times, so I figured it be nice to have a topic on humor, where anyone can add things that made them laugh. I'll begin with this picture which gave me the idea: "Did you said chronic hallucinations?!"

I was initially prescribed this. However, after reading up on the side effects and pharmacology, I concluded it would more than likely worsen my situation. So I didn't take any. I'll get back to this later, but I believe there are many medications available for your specific needs, with a safer preferable profile. Bupropion is indeed worth considering. My mother apparantly took this years ago for smoking cessation. I asked her if she noticed anything at all, even non-related to smoking, and she told me no. But then again, that doesn't really mean a thing. I think it was either Jay or Visual who were considering this. EDIT: Nope, that was Buspirone.. confusing stuff.

Hi Puppeteer. I will respond at length when my mind is more in place again. Perhaps by then you will have replied more lengthy as well. However, I'd just like to say that your views on the activity on the forum are good. I look forward to your participation! I myself sometimes find it discouraging, but indeed: One needs to be active themselves to promote this. Also, there have been several new members having trouble with being approved, and as such there should be a spike in activity once they get through. There are some (quite a few actually) members who remain active despite this, and some contribute to research. I would name them, but wouldn't like forgetting to mention anyone. Those that don't actively engage in research are equally interesting to talk to, and on many days make me laugh. One could say that being too active on the forums can make you focus too much on HPPD. Views differ on that though, and I actually find it one of the few things that puts my mind at more ease, whereas doing other things (or nothing) can make me far more aware of my symptoms, for I notice how dysfunctional I have become. So with that said, thanks everyone! I quote: "Obsession is such an ugly word" I find it more a necessity to spend enough time on HPPD, as how else does one expect to recover from this, moreover help others in doing so? Anyway, these were just some personal views on the subject. Like I said, I'll respond to your situation later, most likely tomorrow.

Shaolinbomber: I'd just like to point out to you that "The Good Drug Guide" agrees with your views. Thought you might enjoy reading it, if you don't know of it already. It's a great resource on pharmacology as well.

I suppose, but many people travel abroad frequently. In the Netherlands there hasn't been a single case of TBE in history. However, I myself have been leeched by ticks in several different countries in different continents. Apparantly there's a vaccin, other sources state GlaxoSmithKline discontinued the production. I'll have to sort that out. Note that the vaccin was for TBE (Tick-Borne Encephalitis), and not for Lyme specifically. Knowing that, I will definitely get a Lyme test. If they come back negative, I'll do my best to get a vaccin. This solely for the reason that contracting (another form of, as some view HPPD as Toxic Encephalitis I believe) Encephalitis, or Meningitis, or both, with HPPD would probably make things a thousand fold worse. For this reason, I would recommend to others to consider this. bpl: Do you have TBE or the other flavor?

Seriously? This was on the news? Oh well, was in 2008. Thanks though, I hadn't seen this yet. For the sake of anonymity I considered not sharing the following, but then realized I had already indirectly done so, and should be less paranoid about it. This is the person I am currently seeing. So far he's been very helpful and understanding. More so than any professional I have contacted about HPPD. I strongly advise any Dutch citizens to contact him when seeking help. I'll make a translation of this interview for everyone to read later.

Thank you! I guess you already know this, but I'll point it out anyway: The study suggested Keppra can take quite the while to work, sometimes even up to a year. Dosage might also be a thing to consider. What works for one, might not work for the other. Moreover, my HPPD is MDMA related, whereas yours is (correct me if I'm wrong) LSD related. This could make a difference to what works and what doesn't.

This is awesome!!!! Thank you so much! This stuff is really interesting. Great find! I'll post a more elaborative (is that a word? sigh) reply later. More epigenetics! I suggest you have a look over at my findings on Resveratrol (can be found under "Research Articles"). Let me know what you can grasp from it, if you like.

Coluracetam. You might come across a post I made in over-excitement, which got be banned for a week. I hadn't read the forum rules, and figured it would be alright to request to buy the stuff, seeing as others make such requests on that forum all the time. But hey whatever, I made a mistake and I literally can't apologize for it. Oh well, such is life. I've requested a custom synthesis lab to have a look and make me an offer instead. Just a heads up: all experiences quoted below come from the thread above. Just thought I'd spare you some time skimming for other possible sources. Furthermore, after all this work, I found someone had already summed up a lot of experiences at this page. Blue highlights show undesired effects, red shows desired effects, green shows questionable effects in regard to favorability. Anecdotal effects on vision and other senses "I could almost TASTE and EAT the colors, so to speak" Sounds like that could help with DR. "Informal review: this is a very active substance. Indeed, there are changes in visual perception of color. I have tried oxi, ani, pi and prami -racetam without any color enhancement that I could perceive consistently above placebo status. However initial test of this mystery substance that came in the mail to me has got me saying "whoa" even just looking around my room. Driving around outside with these fall colors on the trees is an absolute pleasure." source "I am pretty sure I noticed an enhanced verbal fluidity and more "high def vision" like I do when on Piracetam" source "The visual enhancement and extra clarity+swiftness of mind reminds me a lot of lions mane, both which for me just keep growing with each dose. it happens slower on lions mane though. My vision, mostly outdoors, now pretty much always appears in high definition HDR with a bit of...an indescribable magic/fantasy/artistic look to things mostly outside(I suppose almost exactly the same as a low low dose of a psychedelic, no distortions just a very similar if not better extreme enhancement of vision that also makes things, mostly nature, have that indescribable awesome looking feel). I get this effect even when it's been a while(24hrs+) since I've dosed and it seems to build with every dose. The fantasy/awesome look to everything is a lot like aniracetam(of which the effect also builds for me but coluracetam's has already surpassed the visual enhancement I get from aniracetam, and I don't believe aniracetam's visual enhancement lasted after most of the other effects left). The visual effect also started out very similar to piracetam's visual enhancement of very bold colors and detail enhancement(this effect grew very very slow for me but eventually got very obvious, not sure how long it lasted after I stopped taking it, since that was awhile ago). I went to two concerts and the music and lights, while awesome anyway, were incredible... it was like a low-medium dose of MDMA or other serotonin+dopamine releasers except without the euphoria and mostly in those respects." source "I noticed a change in vision, colors do seem more saturated , cognition became more lucid, uplifted feeling, I feel lucid and calm. working memory is better" source "I haven't dosed in 4 days and the visual enhancement is still there, just not as obvious as when on it. pretty coool..lion's mane's visual enhancements lasted a while after the last dose too." source I'll do some extensive research on Lion's Mane Mushroom later, as it seems to have visual effects as well. Note that @bpl4269 has also found mitigation of symptoms when using Lion's Mane, among others. "I noticed memory seemed to stick better, and color changes were very noticeable. The color effect still persist. Also seemed to make me quicker in speech." source "I felt more clear and lucid and decided to meditate. A 1 hour session was no problem. I was to the point where I couldn't feel my physical body but my energy body started vibrating which is the early sign of the energy body moving out the physical body" "It also definitely enhances meditation which I have mentioned." source "I have bad eyesight and i think the coluracetam has improved my eye sight. My eyes have not been straining to see anymore, I was kill all my friends in MW2 (Modern Warfare 2; a FPS game for those who don't know) because I see them when they were just tiny specks on the screen. I gave some to my dad to take before bed and he was able to sleep much better. He has sleep apnea and he said it helped him breathe better and the effects lasted several days with out repeat dose" source "What I do notice is some kind of serenity while on coluracetam, coupled with easier memory recall of hard-to-remember info" source "I too initially noticed color pronouncement, but like others have mentioned, it seems like overall visual enhancement/acuity. The expectation effect appears to be intruding here, so I'd just encourage everyone to not focus too hard on anything that's been reported and try to be receptive to your own experiences. Feelings of contentment, peace, and increased ease around others and life in general is noticeable. Sometimes I have some situational social anxieties, but they essentially disappear with 30mg. I was in a cellphone store for two hours waiting to receive a phone upgrade, and yet I was okay with this. My internal dialogue was forgiving of the employees for their slowness, and I enjoyed talking to the people there more so than I normally would have. This effect might also be heightened due to me being more content, and thus more likable, thus leading to friendlier/deeper conversations that dig beneath the superficial layers I commonly experience when interacting with strangers (especially strangers who want your money). Anyway, this might be valuable to people with OCD-like head running thought patterns Coluracetam may have taken the edge off adderall a bit, but more significantly, it greatly increased my sense of taste, perhaps even making things tastier, not unlike cannabis can do. I also experienced tracers, where lights would "paint" the space where they had been moments before in my visual field. Sometimes the tracers even became detached from the light source itself which seems especially odd now that I think about it. (note: Well fark, this sucks. One possible explanation is the combination of Amphetamines. Consider that MDMA is also an Amphetamine.. I don't know, but IMO I think the Amphetamines caused this effect. You should know that I'm largely biased about Amphetamines. Lastly, he does not report having this effect when combined with Cannabis)" source " 2nd day taking this: 10mg/day Good: * Visual enhancement * Improved sociability * Improved patience * Better right brain activation - I can image stream fiction more easily. (note: Whatever that means.. I think he's referring to visualizing skill) Somewhat Negative: * It was a little too much in the foreground. The perception changing is a bit distracting. * Mood changes and day resets (when earlier in the day seems like a different day) were more frequent. Nothing radical but just felt like switching between moods was a bit too easy. This effect is a bit like Lion's Mane. * Night vision is better but the intensity of lighted vs non-lighted areas is a bit disconcerning. " source "The effects I noticed were really quite nice, and this was only after one dose! I noticed increased sociability, mildly increased abstract reasoning skills, massive mental relaxation and a profound effect of visual acuity and appreciation of natural and intricate forms. At one point I was enraptured by a passing cloud for a few minutes, just absolutely lost in its beauty and complexity." source (note: Hmm... The reported effects sometimes seem to mimic those of classic hallucinogens/psychedelics. No absurdly weird things reported so far, aside from that Amph combo) "The strongest effect seems to be anxiolytic. I can see why this was being developed to treat depression and anxiety; I take this, and I am a lot more calm and relaxed. Also, like piracetam, it makes being happy easier, and makes music better. I’m not sure if my vision is any different; the question is too subjective, too prone to the placebo effect, for me to answer with any confidence. That said, I’m not 100% certain that my vision is unchanged, unlike piracetam, which I am convinced has no effect on my vision." source "The vision effect is still growing to the point it's on par with how psychedelics enhance vision(obviously without the distortions haha). I have had no negative thoughts at all, which is somewhat odd, I'm not a depressed person, but when you are tapering off benzos... you tend to get negative thoughts now and then and slightly depressed at random, but it seems to have stopped both of those from happening." source "I have also noticed to be more into my self (note:DP implication?), more present in that sense of word.. but I should measure Colu effect more precisely, its still a lot anecdotal here.. As I am taking it with noopept, I sometime notice myself staring on landscape fascinated how beautiful it is (probably vision effects, which I think have antidepression qualities)." source "The visual enhancement is pretty intense at times like Golden has mentioned similiar to Psychedelics but there are no tracers or anything moving just everything looks really bright and sometimes certain scenes look more like a high def painting or an enhanced picture like some of the Photo programs they have that enhance the quality of pictures making the scenes look somewhat fake to a certain degree due to the enhancement. 'm really happy about the improvements in Social Situations because I've struggled for a very long time with this issue and this seems to help in confidence and ability to say what I want without studdering. At other times though I feel somewhat anxious which is strange. Its like the drug doesn't feel like it has anti anxiety effects until after I realize how confident I was." source "I was able to make some music again which was awesome, since my skill at that started going downhill after being on benzos. And yeah joelski28 I agree with your descriptions of the visual effect, heres some HDR pics (note: click source to see the pics.. they're mushrooms. ha-ha!) I took a while ago that remind me of it. Overall I really really like coluracetam and it feels like its building up my brain in a positive way, hard to describe really, but similar to lions mane if anyone hass noticed the effects from that they are pretty similar" source "Tried 1000mg nefiracetam + 2000mg piracetam + 20mg coluracetam. The high definition vision is apparently enhanced GREATLY by nefiracetam. So is the calmness, but I expected that(intense calmness has always been the main effect of nefiracetam for me). It's definitely like HDR photography, in that the dynamic range of dark and light colors is increased. It's finally surpassed the max visual enhancement I got from aniracetam by a rather large amount. Simply looking in the mirror I look as if I am looking at myself through the lens of a professional photographer..with perfect lighting and shadows haha. If you can't tell, I'm more the creative type, so things like enhanced perception and creativity stand out more for me. I'm going to attempt coluracetam with a psychedelic...I'll let you know how that goes." Note: Well.. I'm VERY curious to read how that goes. source Here's his update on the experience with the (unspecified) psychedelic: "coluracetam + psychedelic = saturated colors to the point they seem like you can feel them in your head... or taste them or such. extremely crisp vision and 3d perception. >>>Less distortions than usual<<<, but more visual enhancements, if that makes sense. It was pretty much an additive effect on most levels. Sound felt like I was in a sea of the music surrounding me for what felt like miles. It certainly enhanced the perceptual elements of the psychedelic to the point it felt extremely amazing, more so than usual...ha." source So that was the first stable anecdotal evidence that Coluracetam has great potential in treating HPPD!!! Here's another report of that individual: "I noticed it's very hard to have unwanted negative feelings, like aniracetam, it just seems to remove the possibility of falling into that pit. Of course if something happened like a pet died, I would be able to cry easily. It's like they (note: say what? who?)rationalize negative thought a bit more. Visual effect seems to only grow or increase when outside studying intense geometry and textures of the world, while when inside for most of the day it appears to slow down or even lower it's visual enhancement (note: this doesn't mean it is causing him vision deficits, he's merely stating the enhancement is less, but still there). I think possibly, since I wear glasses, but got them in highschool I will always be extra WOW'd when looking at many things with them on, so maybe it's helping my brain adjust to the better sense of sight when its being utilized." source "I had visual quality problems as well. aniracetam is the most colorful racetam with prami the neon colored effects at grocery stores stayed for about a month. what helped enhance this more realistically was: iboga (Note: I tried this myself... I strongly recommend you do NOT use Iboga. My vision was substantially worse for a month or so, before returning to HPPD-baseline. There has been one report of HPPD clearing up after an Iboga session, but it was merely a single sentence mentioning it. Iboga is an entheogen, and as such, with HPPD it is highly recommended to NOT partake in such activities.) DHA/EPA methyl-b12 lions mane (note: this seems to be coming up a lot) another thing to try for visual enchancement is nicergoline (note: I will look into this later) + hydergine the trick would be to actually get the fatty acids in there and the neuroinflammation out of there to build better visual cortex. (note: well sound all fancy, but no scientific sources. If that was the case, taking an NSAID would improve symptoms, no?)" source "I've noticed a reduction in social anxiety. Colors appear to be more saturating and interesting. Concentration and quickness of thought are also noticeably improved. During lectures this week, I've had less intrusion of unwanted thoughts (note: I myself have suffered greatly with intrusive thoughts since acquiring HPPD, thus I find this a highly significant effect) and daydreaming and have been able to really focus on comprehending what is being taught." source "Interestingly the visual enhancement is still here strong after 2 days of no coluracetam and then added on a total of 200mg benedryl(aka DPH, to try to get back to sleep) and its still here clear as ever, just thought that was interesting." source This post has lots of good stuff too mention, and is basically all summed up, so I figured it be pointless to add that here. One comment was: "semi-extreme visual enhancement/embellishment when in aesthetically interesting places(nature, music event w/ lights and such, fireworks)" I really suggest you take a look, sounds freaking wonderful to me. anti link glitch text