Onemorestep

After discontinuing Keppra in November I decided to give it another shot. I stopped before due to a bad reaction to Ritalin which seemed to change some brain functioning and caused the Keppra to make me very physically anxious. So far far so good. Took 500mg today. It's been cutting down on the panic a lotttt but the depression less so. I'm also reacting differently to it this time. Less euphoria like I had before when I was titrating up. But my brain is very different than it was last time so we'll see how this goes. No physical anxiety from it. today it made me pretty sedated for a bit. Felt a bit drunk tbh. However during the day I swam in the ocean and built a sand sculpture--two things I wouldn't do normally. Good signs. Some decrease in libido but that's normal.

I'd be interested to see what gene mutations you have. I recently got mine done and there's 43 of them. Maybe theirs common mutations in all of us HPPDrs

I took this prn for several years. I found I have a very naturally high tolelance for the stuff. Pretty benign though. Dont take if you have a family history of Peyronie's disease. Don't take at the same time with cialis or viagra, or other pde5 inhibitors (you'll probably pass out).

For those of you interested here is some some information about the antihyperalgesic effect of keppra. Seems to involve many systems. Activation of these systems may allude to why it benefits people with hppd psychologically. "the results of the present study show that levetiracetam induces antihyperalgesia in an inflammatory model of pain and that this effect is at least in part, mediated by α2-adrenoceptors, GABAA, opioid and 5-HT receptors." https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2989589/#!po=61.3208 -oms

Honestly I'm unsure what else to try. Unless I'm on Keppra, I am sensitive to most medications. Keppra has a lot of mechanisms but some primary ones involve gabergic modulation. That inhibitory action allows me to tolerate more meds/supplements. For instance while off it it I can't even really take B vitamins. They increase my methylation processes and that ramps me up too much. In the past I've tried lamotrigne, depekote, sinemet (gave me a rash (not the lethal one) that never went away on my face. Thank God for facial hair), ssris, Wellbutrin....honestly a huge score of meds. Some of them were before the hppd got really bad though. For some reason racetams really are able modulate my brain function more than any other drug. Unfortunately they seem to have side effects that aren't too great. oxiracetam improved things immensely. My visuals almost completely went away. 95 percent reduction. But I think screwed up my hypothalamus with it. After I stopped I Lost the ability to have sex for six months. Had no hunger or thirst response either. It was nuttts. Immense anxiety etc. this may have been caused by abrupt cessation though. Who knows. When i get the nerve I'll start the low dose Keppra. At least I know that after a certain number of months off it I'll return to normal if I find it isn't working. I just want to be able to have interests again haha

Hey guys! So I'm thinking of giving keppra another go. It really kicked my physics pain that's been around since getting hppd in the butt and did wonders for reducing DP and bringing back my cognitive abilities. I could enjoy music again on it! Really was able to find serenity. However.... ...one side effect i am worried about is I noticed I became sort of sociopathic when I was on it? I seemed unable to put myself in other people's shoes as well. It really tore up a year long friendship and romantic relationship I had. Took about 6 months being off of it for my morals to come back. I was very technically ethical when I was on it. Hard to describe. Spocklike. It felt a little bit like there was a barrier between me and acknowledging that other people had emotions and feelings too. Has anyone else experienced this? I think going back into it if I keep that in mind I'll make better decisions. Plus I plan to just take between 10-50mg instead of the 1500 I was on. I read about a guy on here who did that and recovered a lot even though it took some months. I find this low dose pretty good at reducing my physical symptoms too. hope everyone is well! -oms

I've done the keto diet on and off the last four year-- one on, two off, and one on. I find it's a great diet for energy, mental clarity, anti inflamitory support, and self esteem (you're gonna lose a lot of weight. I also eat no gluten (there just isn't much you can eat with gluten that doesn't also have carbs). For emotional support, it is great at reducing anxiety. Also without the insulin dips and spikes from eating carbs ones mood is more stable. in terms of weight loss, I went from 215 down to 164 where I am stable (I'm 6ft). It definitely made me feel better about myself! Just be prepared for a bit of the keto flu. You're going to crave carbs like no other. In fact you won't feel hungry for anything else. This will last 1-2 weeks and then your taste buds will change. I sometimes eat straight butter at restaurants because it tastes so good to me haha. if you want to get into ketosis FAST there are some thugs that will help: exercise and no cheating. Keep caloric intake at about 1600 calories. You can also spend 3-5 days eating one stick of cream cheese a day and only that haha. I did that for two days; this wasn't as bad as one would think. I've heard dairy ain't great for you but can someone school me as to why? I've never really looked because it's a huge part of me keeping my sanity not eating carbs. I could live on Brie hahah. hope it goes well for you! Just stick it out through the cravings and low energy and I promise you'll feel better soon

WOOOOOO BOY HOWDY THIS IS SOME INTENSE STUFF. Withdrawals are nooo jokeeee. Although I've done an incredibly fast taper which I'm sure has made things more rough. I started on the 31st and now on the 11th I've cut my dosage beyond half. starting dose: .5mg Ativan twice daily 300mg gabapentin twice daily i cut the morning Ativan dose off the bat and waited a week and now I'm shaving around 20 percent a day off the remaining .5mg. Currently at around .25mg at night now the gabapentin I just tapered down by 20-50mg a day. Now I'm at about 60mg in the morning and 150 mg at night. its hell but getting through it! luckily I was only on them for about 8 months at a fairly low dose and not years.

Glad to hear you're feeling more with it! Yea wish we had better drug education in school. Had I known about what hallucinogens and drugs in general could do to me my life may have turned out differently. ...but then again I was a defiant one back in the day haha.

I'm finding that the more I withdraw from these downers the more these vitamins make the panic worse. Discontinued today and feel a lot better. Once I've stabilized I'll re enstate them and see how I do. B vitamins are just a bit too stimulating right now!

Like a lot of nootropic blends on the market you can just get the ingredients to these and do this yourself. Usually for a fraction of the cost. ^if you have bipolar polar IT IS seriously recommended you speak to your doctor before supplementing with acetyl-l-carnitine. It can induce psychosis.

Just wanted to say if you have bipolar, inositol will probably send you into mania. I do not know if I have bipolar but signs point to yes. When I was on keppra I could handle inositol okay but since coming off if I take it I get crippling anxiety but also feelings of serenity and closeness to family and friends along with a strange urge to dance xD the dancing thing is the most interesting. I don't really like to dance. I don't get the feeling of fluidity I think other people do. But on inositol I feel that fluidity. I'll be doing ballet in my living room haha..... sounds kinda like mania.

So still doing well on a few of these guys. 25 mg b6 P-5-P form 2000 mcg hydroxo b12 10,000 mcg biotin 500mg vitamin C 600 mg NAC 3x daily some over the counter GABA (unsure if this does anything tbh) optimal liposomal glutathione (400mg phosphatydilcholine, glutathione) 30 mcg methylfolate (working my way up very slowly on this to prevent inflammation) After researching Gabapentin I came across some information that it can reduce levels of folate which would put stress on the methylation cycle. I already have many folate methylation gene mutations. https://www.ncbi.nlm.nih.gov/m/pubmed/21246600/ http://www.uofmhealth.org/health-library/hn-1390003 interestingly enough about 2 days ago I experienced a SIGNIFICANT reduction in the pain I've been experiencing from Peyronie's disease. Whether this is from coming off the gabapentin and benzos or because I'm replenishing my b levels and stabilizing the methylation process I do not know. Or perhaps the increased glutathion is aiding in inflammation reduction. Regardless I'm happy with the results. i recommend anyone who is taking anticonvulsants (this includes benzos) to get their biotin, calcium, b12, b6, and folate levels checked. edit:2021 i did not have peyronies disease. I believe it was a collagen issue cause by (theoretical) poor copper utilization. Keppra did cause this issue to be substantially worse (it interacts with a lot of vitamins involving the methylation cycle). I do not use these types of vitamins anymore

I'm sorry to hear you are suffering well i dont know much about antipsychotic withdrawals but i I imagine your brain has compensated in some way for them over time and now needs to adjust back. in terms of the depekote it's not 100 percent certain how that works but scientists think it does increase GABA. Usually gaba is inhibitory and would contribute to brain fog etc but if you look at the withdrawal symptoms for drugs that increase gaba confusion and cognitive problems are on the list. The gaba system is pretty sensitive and it can take time for things to return to normal (I'm acutely aware of this as I'm currently withdrawing from gabapentin and attivan). I wouldn't worry too much. Just try and get adequate sleep, food, and relaxation.

I just started taking some krill oil and I went to the beach today for some good old vitamin D you know interestingly enough I've been craving fish a lot recently. Odd because I've always disliked fish! Also in terms of the hair loss... it actually might be gabapentin causing it. I've been off keppra for months now and the loss has only gotten worse so I googled a bit and there seems to be quite. A few people saying they're having hair issues on gabapentin. But you know it's the internet so who knows.

Also since taking keppra my hair has been falling out and I would like to figure out why... I'm hoping folate zinc selenium and molybdenum willl help.

I think I'll try a few. I'm mostly concerned with my antioxidant capabilities being impaired and high levels of ammonia. And superoxides. I do wish they had a section for WHY they think these are good supplements though. I should eat healthier. I'm on a keto diet and it treats me well so I eat a lot of salad but sometimes I fall into just eating too much sausages and cheese ;p

I'm going to add them slowly one by one I guess :x pretty anxious about it. I have bad reactions to stuff sometimes so not looking forward to finding out which does.

Hey guys-- thought some of you might be interested in looking at a fellow travelers gene mutations. The reason I'm posting this in Medication and Other Treatments is that this site, NutraHacker, offers suggestions for supplements and medications to support and avoid in aiding ones bodily functions in light of mutations. https://s3-us-west-2.amazonaws.com/reports.nutrahacker.com/mutationReports/NutraHacker_Complete_Mutation_Report_Customer_028a23b7-9f46-4616-8b5a-39aa49a6e692.pdf Anyone who has had experience with any of these supplements/drugs and wants to share it would be most appreciated. Or if you have any knowledge about the genes themselves feel free to speak up. I know about some like COMT and MTHFR but others are out of my paygrade. For instance, I just learned that selenium is great for the thyroid but if youre deficient in iodine it will make things worse. So interactions etc please let me know XD I listed the supplements below that im supposed to take and avoid. There is some crossover and Im supposedly meant to prioritize based off of my own personal experiences with the conflicting ones. Hope you guys find this as interesting as I do! Ive already started taking Hydroxy B12 and it definitely helps. Encourage: Zinc Whey Vitamin K Vitamin E in tocotrienol form Vitamin D3 Vitamin C Vitamin B6 Vitamin B3 Vitamin B12 Vitamin A TMG Theanine Taurine Sulforaphane Selenium SAMe inhibits Sage Rosemary Rooibos Riboflavin for high blood pressure Ribo-5-phosphate Reduced forms of folate Progesterone Potassium Possibly ketogenic diet Phosphatidylserine Phosphatidylcholine Ornithine/Arginine Ornithine Omega-3 fatty acids like fish oil NAC MSM Molybdenum Methyl B12 Manganese Low fat diet Lithium orotate L-methylfolate Iodine Hydroxy B12 (hydroxycobalamin) Grapeseed extract Glycine Glucarate Fiber Fat soluble antioxidants Diindolylmethane Curcumin CoQ10 Choline Cardamom Beta-alanine Avoid: Vitamin E Vitamin B6 (P-5-P form ok) Taurine Sulfates Noise (greater chance for hearing loss) Nicotine MSG Methyl donors Methyl B12 High fat diet Green tea Grapefruit Folinic acid Folate Estrogens EGCG Curcumin Cumin Cannabis BCAA Androgens Much love, OMS

Bump. Ive had a return in hypertonia caused by successive TBI's (previously in remission with use of Baclofen; cannot tolerate side effects) and wish to give this a try as it is one of the few treatments for this horrible muscle cramping and pain.

Great; even before benzos and GABA I really only got around 5-6 hours of sleep a night :x

So I started taking 1mg of Ativan and 600mg of gabapentin about 6 months ago and am thinking about how to get off of them when I'm out of college for summer vacation. If anyone has any suggestions that would be great. I divided the dose in half and am takin it twice a day now about 12 hours apart from each other. I think I'm experiencing some withdrawal symptoms already. Do you think that's because the agonization is less potent even though I'm dosing more frequently? Would it he be a good idea to move to .25 4 times a day and 150mg gabapentin 4 times when I'm more comfortable at this level? Then I can start reducing the individual doses. Kinda an odd method but idk seems like it would at least make it less up and down. also considering going to get MeRT done (form of TMS). I went off 1mg of Ativan (sometimes two) that I had been taking for three months very quickly using this. I was already in hppd hell so I don't know if I had withdrawal symptoms. let me know your thoughts.

After several experiments with valerian I've come to the conclusion that I can no longer tolerate it. It helps so much with sleep and the next day I feel like I have large amounts of energy and a significant relief of physical malaise. I even feel like dancing. However I'm starting to realize it's more of a mania than just a reduction in symptoms. I don't seem to make good choices... (looking at you night in Bangkok where I spent $1000 on a dinner and made some other risky choices ;D) ive noticed too that after the mania there is a huge increase in anxiety and depression. The longer I've been taking it the worse the rebound is. I don't know if this is normal for hppd though. I've watched a similar reaction in those with bipolar (tonight in fact; I had to stop a girl from going on a walk in the snow without shoes...)

Hahah I guess I should specify it SHRUNK my member xD and still I have pain months after the initial reduction. If I have sex and hurt it in any way it will form scar tissue within a few days too. Scary shit. I should mention I always have the 1 percent rare reactions to drugs. So if you aren't overly sensitive go ahead and explore I just am not one of those people who can do it safely it seems. Shame. It really improved my quality of life.

Hey my names Trent too! I've never had any issues getting benzos in America even before hppd. Best to have a doctor who knows at least a bit about hppd. Be careful though. Benzos can be awful and before you know it you've been on them too long. I've been taking Ativan for 6 months now along with 600 mg of gabapentin. Coming off of them come summer break is going to be hell.