Pimavanserin and other drugs that need to be explored for HPPD/VSS Pathology Research

[isness]

Drugs that need to be further explored for HPPD/VSS Pathology Research

Perampanel
AMPA Glutamate Antagonist

1 positive anecdote of 90% curing HPPD

known to have negative psychiatric side effects

following glutamate theory it makes sense to try it.. also AMPA antagonists are new so they havent really been tested.

Xenazine / Tetrabenazine
Monoamine Depletor

1 positive anecdote of 90% curing HPPDMakes sense it would help following Serotonin 5ht2a theory. it depletes all the things known to make HPPD/VSS worse (monoamines).. Serotonin, dopamine, norepinephrine and adrenaline...

Pimavanserin
Selective Serotonin 5ht2a antagonist

may be expensive

I think this one is obvious. Hallucinogens agonize the 5ht2a receptor so the problem might lie there. Maybe the dopamine actions in other anti-psychotics are whats making some people worse in the long run. This drug is extremely selective to the 5ht2a receptor unlike other anti-psychotics.

 

[Mike]

Primavanserin does seem like an obvious no brainer concerning HPPD/VSS.  Probably a lower dosage over, I don't know, six months or something.  Sort of surprising nobody has gone there. 

[Mike]

Doctors probably have two week trial packs and there is this thing called insurance...

Edited April 16, 2023 by Mike

[Jay1]

Seems Pimavanserin is not available in the UK, shame.

[Fawkinchit]

In glutamate theory the neurons are theoretically lost, taking a glutamate antagonist or even reverse agonist would not remediate the loss of said neurons. It could however be a potential treatment for symptoms.