Pimavanserin and other drugs that need to be explored for HPPD/VSS Pathology Research

[isness]

Drugs that need to be further explored for HPPD/VSS Pathology Research

Perampanel
AMPA Glutamate Antagonist

1 positive anecdote of 90% curing HPPD

known to have negative psychiatric side effects

following glutamate theory it makes sense to try it.. also AMPA antagonists are new so they havent really been tested.

Xenazine / Tetrabenazine
Monoamine Depletor

1 positive anecdote of 90% curing HPPDMakes sense it would help following Serotonin 5ht2a theory. it depletes all the things known to make HPPD/VSS worse (monoamines).. Serotonin, dopamine, norepinephrine and adrenaline...

Pimavanserin
Selective Serotonin 5ht2a antagonist

may be expensive

I think this one is obvious. Hallucinogens agonize the 5ht2a receptor so the problem might lie there. Maybe the dopamine actions in other anti-psychotics are whats making some people worse in the long run. This drug is extremely selective to the 5ht2a receptor unlike other anti-psychotics.