isness Posted March 5 Report Share Posted March 5 Drugs that need to be further explored for HPPD/VSS Pathology Research PerampanelAMPA Glutamate Antagonist 1 positive anecdote of 90% curing HPPD known to have negative psychiatric side effects following glutamate theory it makes sense to try it.. also AMPA antagonists are new so they havent really been tested. Xenazine / TetrabenazineMonoamine Depletor 1 positive anecdote of 90% curing HPPDMakes sense it would help following Serotonin 5ht2a theory. it depletes all the things known to make HPPD/VSS worse (monoamines).. Serotonin, dopamine, norepinephrine and adrenaline... PimavanserinSelective Serotonin 5ht2a antagonist may be expensive I think this one is obvious. Hallucinogens agonize the 5ht2a receptor so the problem might lie there. Maybe the dopamine actions in other anti-psychotics are whats making some people worse in the long run. This drug is extremely selective to the 5ht2a receptor unlike other anti-psychotics. 1 1 Link to comment Share on other sites More sharing options...
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