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@help123i think its very possible since tinnitus is so common among hppd/vss. If hppd/vss is Neuro inflammation then yea def. This drug is an anti inflammatory and also has a free radical / anti oxidant mechanism

A few of us are doing a group buy for ebselen / spi-1005. Its used to treat tinnitus and meiners disease. Looks interesting to say the least! Look for us on visual snow reddit. Dm me. My discord is @iznezz @Fawkinchit Looks like this drug is involved w oxidative stress n whatnot. Is that still your fav theory?

Are you serious? This drug has been out since what 2016? People were so psyched on this board when they heard about this drug coming out.. Now since its come out.. Crickets?? It’s a fucking 5ht2a antagonist. Of course it will help me. So not a single person here had tried it?? You got ppl here getting scripted much more dangerous typical antipsychotics ALL THE TIME. Why is there no mention of pimavanserin??

Drugs that need to be further explored for HPPD/VSS Pathology Research Perampanel AMPA Glutamate Antagonist 1 positive anecdote of 90% curing HPPD known to have negative psychiatric side effects following glutamate theory it makes sense to try it.. also AMPA antagonists are new so they havent really been tested. Xenazine / Tetrabenazine Monoamine Depletor 1 positive anecdote of 90% curing HPPDMakes sense it would help following Serotonin 5ht2a theory. it depletes all the things known to make HPPD/VSS worse (monoamines).. Serotonin, dopamine, norepinephrine and adrenaline... Pimavanserin Selective Serotonin 5ht2a antagonist may be expensive I think this one is obvious. Hallucinogens agonize the 5ht2a receptor so the problem might lie there. Maybe the dopamine actions in other anti-psychotics are whats making some people worse in the long run. This drug is extremely selective to the 5ht2a receptor unlike other anti-psychotics.

Following the excess glutamate theory: these should help HPPD. One anecdote of Perampanel (AMPA glutamate antagonist) 90% curing HPPD. Has anyone tried any of these?

There is one anecdote of this curing someone. Why would this drug do that? I know there was a study w Abraham.. some other drug for Parkinsons that seemed to help HPPD. A COMT inhibitor. Dopamine and serotonin always seem to make things worse.. Wouldnt it make sense tetrabenazine a VMAT2 inhibitor would help since it depletes monoamines (dopamine and serotonin)? Lets explore this more.

Theres one anecdote on this forum and the subreddit about Perampanel 90% curing one guy. People have been saying HPPD is excess glutamate for a long time right? Perampanel came out in 2016. Makes sense not many people would try it as its been expensive. Why arent there any studies on this yet? This community is a shit show. Lets explore this? People saying its glutamate then someone comes through and says they cured themselves by blocking glutamate and no one bats an eye.

i think a subreddit dedicated to figuring out the pathology would be ideal.

Who ever is running the show on reddit/discord right now is telling people HPPD is in our heads. This can push away researchers. It's already so hard for people to take HPPD seriously. Also supposedly a new rule on the subreddit: no talking about any drugs except clonidine, keppra, lamictal, and tolcapone. This is to prevent kids from hearing about benzos or other drugs w a few anecdotes and trying them which might worsen their symptoms. So many rules these days. This is the complete opposite of what it used to be like, here.. I miss the old days when we would take every anecdote seriously and explore it.. research it.. Someone came through the subreddit and said they took Xenazine (tereabenazine) and it cured them instantly. Id love to explore that. Does anyone know why something like that might happen? Less dopamine = more GABA? Is there an active discord for this message board? I want to fix this community. I think reddit is not doing a good job and funneling this energy. We have all these people with HPPD coming through and they are being so misguided. Can we direct people here? tolcapone study- what happened with this? Whats the leading theory on HPPD pathology these days? Is it mTOR or COMT related? Its an over active thalamus? Someone please bring me up to speed.