Very recent article about treatment using lamotrigine

[propat45]

I found this article published in June of 2013.  It's definitely worth reading.

 

I tried uploading the pdf file in research articles, but the file is too big.

[onedayillsailagain]

Just gonna copy paste the abstract here:
 

Abstract

Background: Despite a multitude of etiological and therapeutic approaches, the exact pathophysiological mechanisms 

underlying Hallucinogen persisting perception disorder (HPPD) remain elusive. Rather, in each individual case, specific risk factors 

and different vulnerabilities form part of a multifactorial origin of this rare but highly debilitating psychiatric disorder.

 

Case: The following case report describes the history of a 36 year old male who has been suffering from a visual perception 

disorder for the last 18 years. At the age of 17 he used LSD for the first time, having consumed cannabis and alcohol on a regular 

basis since a year earlier. 

 

Descriptions: After one particular LSD trip at age 18, the patient suddenly developed persistent visual disturbances including 

small-sized, colour-intensive, flickering, geometrical patterns; intermittent after images of objects in the visual fields, and trailing 

phenomena of moving objects. Results from the Early Trauma Inventory (ETI) questionnaire indicated significant mental trauma in 

childhood and adolescence. Brain MRI and electrophysiological investigations (median nerve SEPs) revealed a few disseminated 

subcortical lesions. 

 

Conclusion: Upon experimental treatment with lamotrigine, the patient experienced partial to complete remission of the various 

visual disturbances. With its potentially neuroprotective and mood-stabilising properties, lamotrigine may offer a promising new 

therapeutic approach for the treatment of HPPD.

I'll read the article later.. Case reports are generally speaking not so useful, though it may indicate further implications.
Judging from the abstract, they're thinking that lamotrigine's (potentially) neuroprotective and mood-stabilising properties contribute to symptom remission.
AFAIK there are many substances that have these properties along with anti-convulsant action. I do know Lamotrigine has been used for both DP and HPPD with marginal success, so I guess if anyone is looking for a new attempt at treatment, they could consider Lamotrigine for sure.

[Ghormeh Sabzi]

This is a great find! Thanks for posting it. It gives a brief description of HPPD and studies to date as well. How did you come across it?

 

Lots of people are after a quick fix and lamotrigine takes a long time to work - so that might be why some are not too keen to give it ago. That along with its potentially serious side effects. But it is a consideration - especially since there are recent reports of improvements of symptoms on the visual snow Facebook group.

[Merkan]

I still cannot believe that people have not tried the stuff that is out there. Its nothing exotic or fishy. What is there to loose (besides getting a full blown worsening but these types of meds are safe). I do not get it.

[brendan]

Good find. Sertraline crops up a few times.  Anyone tried it?

[propat45]

This is a great find! Thanks for posting it. It gives a brief description of HPPD and studies to date as well. How did you come across it?

 

I googled HPPD and olanzapine and it popped up.  I was looking for one of the case reports of HPPD being treated with olanzapine and fluoxetine.

[zukov]

Thanks for sharing that article dude... it will help me a lot with my doctor.  

 

From the article:

 

"In a study conducted on 9.400 participants, who had consumed 

LSD for research or therapeutic purposes, not a single case of HPPD 

was documented [20,21]. In an interview of over 500 Navajo members 

of the Native American Church -a legal mescaline using religious 

community- no signs of HPPD were reported [2,3]. These carefully 

controlled prospective and retrospective studies underline the 

importance of a protective setting to counter later anxiety and loss of 

self-control."  

THATS WEIRD

[awalkerphoenix]

I am currently on 200mg os Sertaline. No help yet...

 

I'm also on Depakote 1000mgs.