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Found 12 results

  1. This is a thread meant to expand upon the new research being done upon traditional hallucinogens, their effect on increased excitatory tone via hippocampus and pfc reorganization, the effects of these drugs on ampa/nmda receptors, and excitatory tone in general. The following is a list of drugs that anecdotally hurt/help that also fit into this hypothesis and any other drugs I find that may help as well. mall the best to you all out there. ——————- AMPA/NMDA ratios in slices taken from psilocybin-injected CMMS-susceptible mice were significantly greater than those in slices taken from CMMS-susceptible animals injected with vehicle or ketanserin alone (Fig. 3B). Our preclinical results therefore suggest that 5-HT2ARs, and thus psychedelic responses in humans, may not be required for an antidepressant response to psilocybin, although that can only be definitively established with tests in human TRD. https://www.pnas.org/doi/10.1073/pnas.2022489118 —— 5-HT2A activation and subsequent activation of postsynaptic α-amino-٣-hydroxy-٥-methyl-٤-isoxazole propionic acid (AMPA) receptors by psilocybin is associated with increased glutamate concentration. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8156539/ —- AVOID: How nicotine effects this and us. Interesting as many find nicotine to be anxiety inducing post hppd: “Selective coactivation of α7- and α4β2-nAChRs also sufficiently reversed Aβ-induced AMPA receptor dysfunction, including Aβ-induced reduction of AMPA receptor phosphorylation and surface expression in hippocampal neurons.” https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8156539/
  2. Hello everyone, in advance I wanna apologize for my non mother tounge English and for not really coming to an end with telling my story and maybe using the wrong tread for that post. I‘m not quite sure yet if a self diagnose with HPPD is appropriate for me but I want to tell you about my story, my seizure-similar experiences and my worries about taking meds. i don’t really know when all of this started. I‘m 24 now and I’ve been smoking weed regularly since 2015/2016, never had any noticeable problems with consuming it but could always keep it on a kind of moderate level, smoked everyday but usually at night time and never had problems having breaks inbetween for weeks. August 2019 I went to Indonesia/Gili Islands and „of course“ I had to try one of there mushroomshakes there, Even though I never had drug experiences besides 3 times of mdma and the weed. However, the first mushroom trip was quite pleasing nothing as how I experienced it and the dose was very low as I wanted it to be so I nearly had any hallucinations, my mind felt very clear and I did feel kind of creative. That good and light experience might have taken the my „respect“ of this drug so on that same holiday 2 weeks later I drank another mushroom shake, at night, in my hotel were the atmosphere wasn’t that nice, furthermore my friend I wanted to take it with didn’t notice anything and the dosage was a bit to high for me I guess. I wouldn’t call it having a bad trip, but all of the circumstances kind of freaked me out and I really had to calm myself down throughout the trip. Anyways when I came back to Germany, my home country I ordered some mushrooms from the Netherlands, because I wanted to microdose them, for „selfhealing“ my selfdiagnosed depression that I was to scared to go to a doctor with. In December 2019 I started microdosing for nearly three month, I didn’t feel so much of the positive effects promised but I didn’t stopped smoking while doing it which might me the reason for that, sometimes the day after taking it a felt kinda dizzy and I had that thing called mouches volantes I guess, that seemed like little flys/black dots infront of my eyes, next day I didn’t have anything. Sometimes when I took the dosage in the morning and smoked werd afterwards I got really sensitive to noises which also kind of made me aggressive or I felt like I had to leave the situation. However, all of that stopped when I stopped with the microdosing. At that point I want to say that I hadn’t felt really depressed ever since, anyways I feel like I kind of changed ever since, which I haven’t really noticed as a Problem till a few month ago, that’s why I don’t know if i‘n actually having the HPPD or what it’s caused from. in the past year is started getting more annoyed of people or not really „getting“ their way of living life, I started feeling anxious about talking infront of others and felt Kindle confused when I had too, but it was just in front of my class (i’m studying health science - how ironic I know) and I started isolating myself more, but just felt that I wasn’t as dependent on others as I used too. Then suddenly I started hating the smell and taste of weed, I didn’t like the “relaxing” effects it gave me because I just felt unsatisfied with myself and not good, summer2020 I went on a vacation with my family and didn’t smoke fore 2 month, everything was fine, don’t think I ever felt that good and stable during a vacation in a long period of time. However when I came back to the city I’m studying in and to my circle of friends who is smoking weed excessively I started smoking again too, with the differences that I felt that weed didn’t have any effect on me anymore, I couldn’t smell it, didn’t really taste it, it didn’t make me tired anymore, there was still a slight change but I don’t really know what made me continue smoking, I also noticed that it got kind of Heard- for me to not smoke for a few days because it made me feel really weird, I thought I couldn’t focus as much anymore and I thought I needed it to write on my assignments, I don’t really know. I felt kind of anxious at some points when I was smoking and had those weird episodes which makes me think there might be more connection to seizures. in the past 6 month it had happened that when I smoked time seemed to pass on “double-time” like really really fast and voices of YouTube videos sounded quite weird, sometimes when was reading it felt like it takes me less then 3 seconds to read through a pages and sometimes I could hear my heartbeat really really loud and thought it was really fast but when was measuring it everything was fine. I found this forum where people are describing similar situation but there is not a clear diagnose to it yet, some people are talking about DEREALISATION but some people are also diagnosed with SEIZURES due to those episodes were there was also found proof for it in brain storms. I can’t find an English tread where it’s described but if you type in everything feels loud and fast into google you can find treads liked to derealisation but also to partial epilepsy. on New Years I took mdma and it was kind of weird because I needed nearly double the dose of my flatmate even though I didn’t consume it for 3 years in advance, everything felt fine and I felt happy as I always do on mdma. Next day was fine too, but that’s when I started questioning myself more and more, especially because I felt like nothing really had any effect on my mind or my body, like I was non existent. With that I’m talking about the not getting stoned anymore, being able to take very high mdma doses and just stopping to smoke cigarettes without really caring or feeling any withdrawal about it after smoking around twenty cigs for the past 8 years. I got really worried about myself even though I felt good in general, but somehow too good, like nothing really bothered me or could get close to me without the feeling of being depressed. the experience I made that made me stop smoking weed and being scared of ever wanting to take any kind of drug ever in my life again, also made me go to a psychologist since it made me really panic. I started blaming the weird effect of the weed on me, that I couldn’t taste or really smell it on the weed because I know there was going some bad Chinese chemical cannabidoids around close to the town I’m studying in, anyways when I went to my hometown I brought some of it because I somehow got really used to smoking weed and with that I mean a lot of weed, even though I never had a tolerance with it before or anything I started rolling blunts without feeling anything the weeks in advance. Since I was kind of unsure about the weed after I heard about the chemical Chinese thing I rolled a joint and just put a little tiny amount of it in the joint, when I hitted it first I already felt anxious about it, after 4-5 hits I had to stop smoking because everything started feeling very weird for me again, I tried to do some anxiety meditation and while I was sitting on my Yogamatt my whole body started shaking even though I felt relaxed, the speakers voice got so loud even I lowered my laptops tone to the lowest and everything started speeding up, my environment started looking weird as I everything was drawn (now I know that that’s how it looks when you are derealized) but it was just so much worse then my worst state of derealisation, but somehow feeling calm meanwhile. However, that’s when I told myself I need to stop, I already had made an appointment at the psychiatrist before that situation but there were still a few days to go which where really horrific. I posted about those “fast and loud” situations on an neurological Facebook page where people told me about their kids having experienced the exact same and then were diagnosed with epilepsy. now to the current situation: I got really really anxious about what could be wrong with me, I thought I just got schizophrenia or really bad psychosis, but it was just a really bad state of derealisation and an extrem depersonalize where I couldn’t feel myself anymore and felt like someone else was talking and people started looking differently and so on and I felt tense and sweaty 24/7. The psychologist I’m still seeing weekly ever since diagnosed me with an anxiety disorder, depression and derealisation symptoms caused by a childhood trauma (my dad was killed when I was at the age of two). She prescribed seroquel/quetiapin at the lowest dose of 25mg, mainly because she thinks it heals for the derealisation which is kept up by anxiety and to relax my mind again. I took it at night before going to sleep, my bad derealisation and depersonalization actually went away and I felt really really good even though it’s a very low dose, anyways, I’m not really feeling fine with taking meds which made me anxious about the seroquel and check on google all of the time as if it was my main problem now. When reading the first “bad” experiences I started thinking about it in a more negative way even though it still made me feel as good and motivated as I haven’t felt in YEARS, which also freaked me out because I wasn’t used to feeling that good. My psychologist wants to give me the control over the medicating and leaves it up to me if I’m taking it or not, if I stop taking it every now and then to control how I’m feeling without it and so on. right now and don’t really know what to do. I took the seroquel for 1 month now, last week I stopped taking it because I got scared of all the negative side effects I was reading about on the internet. After not taking it I didn’t have any sleeping problems, anyways I don’t feel that motivated anymore and I’m struggling keeping active as much as I did in the Seroquel. I notice those visual effects as “heatwaves”, sometimes a dot infront of my eyes when I’m reading and a thing that I can only describe as seeing the “molecules” in the air but I had those things the past year every now and then without giving them to much value. now that I’m reading about the HPPD which might be my actual problem I don’t really know what to do anymore. I’m scared that taking the Seroquel will disturb my self healing process if HPPD or make it last even though it might have vanished in its own after a few more month on the other hand I feel better with the Seroquel but with all the posts about Seroquel not being good for HPPD it gets me worries that I might worsen the situation or as I already said, make it stay even though it might have been gone in it’s own after a few more month. I don’t want to try out other things but since the LAMOTRIGIN is used for epilepsy and epilepsy might show the same symptoms of the derealisation I had that I now think came from the HPPD rather then from child trauma I somehow think there could be more connection between it and I should try it out but also with that I’m scared that it makes the HPPD manifest and that it will have even worse negative side effects then the low dose of Quetiapin I’m taking. I’m reading that best thing is not taking anything which I feel too but on the other hand I felt so much better with the Seroquel and now that I’m not using it my brain fog and my unmotivatedness and my anxiety makes me feel worse and tired and I actually need to function. I don’t really know what answers or inputs I’m hoping to get from this post of myself I just felt like I need to share everything that’s going through my mind even though it might be kind of confusing. I don’t really feel supported with those thoughts by my psychologist because as I mentioned she’s leaving it up to me if I take it or not. But I just don’t know. I can’t and I don’t want to talk to her about thinking that I have HPPD because I’m scared that she doesn’t know how to treat it and neither does anyone else around where I come from.
  3. Hey guys, I personally have mild hppd for 2 months. Almost no vs, slight after images and cevs. These symptoms are not really bothering me BUT I have geometric hallucinations which occur when I look at streets/carpets/some walls... This wouldnt be that bad If the patterns I see would not be "evil" like I had on my bad trip. Whats the best med to treat hallucinations? The doctors gave me risperidone but I havent taken it yet. But can risperidone really make hallucinations worse? Is this possible? I guess it can make vs or after images worse, but can it make hallucinations worse? I have only done acid once and have never done any drugs before. Not even weed so staying is no problem for me. I will talk to my doc about lamotrigin. But what is the best way to treat this symptom?
  4. After a lot of research, i came across this medical review : https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3736944/Very interesting and rare hppd study. Overall, it seems that Lamotrigine has been able to cure long term HPPD like mine is , and for good, or significantly decrease visual disturbances and symptoms. I'm actually testing nootropics on many levels, but i'm willing to step-up to more epileptic oriented drugs. Anyone has more input about Lamotrigine on long lasted HPPD (mine is about 20 years old...) ?
  5. Hey guys, My doctor prescribed me lamictal yesterday and as pretty much all of you know, it's one of the more highly regarded medication out there for this condition. My hppd is actually very bearable, the only time I struggle is when I'm alone in the house where the lsd trip happened, which leads me to a few questions. If I decide to take it, and my hppd gets better/worse/stays the same, if I stop taking it will I return to baseline? Has anyone else taken this med?
  6. So given that agomelatine doesn't seem to have done much of anything it's very likely I'll be prescribed Lamictal next Tuesday. When I mentioned levetiracetam the psychiatrist I'm seeing either didn't have much to say about it or didn't want to go there for some reason, but he praised Lamictal and said it'd be the next move in my treatment. Thing is, I know Keppra tends to be the most well-regarded anticonvulsant by members here and seems to have the most success stories, but I'm not sure if that's just because more people have tried it. I'm not well-versed in the pharmacological actions of either and how they differ but a lot of studies/reports seem to regard them as relatively comparable as far as treatment of epilepsy goes. I know there's the study, but is there any reason Keppra was chosen for the study over Lamictal, and were the same study to be done with Lamictal is there much reason to believe the results would be less positive? I really just want to know if there's any concrete reason that I might want to really push for Keppra over Lamictal; I don't especially want to get into an argument about this stuff with a professor of psychiatry unless I'm confident there's a solid basis for doing so Oh, and while I'm at it I'd like to ask: if one's HPPD fails to respond to treatment with one anticonvulsant, is that reason to believe it won't respond to another and that avenue of treatment should be abandoned?
  7. So, it's been a couple months and I'm at my target dose of 200mg lamotrigine daily. Still on 2mg clonazepam daily, but will be starting a taper off of it within the next month or so. No signs of addiction or dependence so I'm not too worried about tapering off it. I'm pretty much the same as I was when I posted the first report. However, the double images/ghosting has improved quite a bit and now seems to come in waves rather than being constant. There are days where it's the same as it was before treatment, and the there are days where it's almost not noticeable unless I purposefully look for it. Another thing of note, it seems to now only occur with brightly colored/reflective objects that are being hit with intense light OR with lights that emit at a high intensity. Also, it sort of follows a cosine like trend where it's at its worse in the morning and night, but not so bad midday (this is perhaps a function simply of eye adjustment, i.e., the eyes adjust to light after being in darkness for an extended period and the eyes adjusting to darkness after being exposed to light for an extended period of time). Ghosting/double vision with text on a computer screen is almost nonexistent now, it comes and goes but for the most part, it isn't present. However, all other archetypal symptoms are still present at their normal intensities. I plan on going the full recommended 12 months to see how this turns out. The improvements make me hopeful. Another thing of note, I will be starting a course of haloperidol soon due to an increase in psychotic symptoms (pdoc is starting to get worried and wants to get this under control ASAP before I end up in the looney bin). My target dose will be 5mg once daily, starting at 2mg once daily. He recommended it since it primarily affects only the dopamine receptors, specifically the D2 receptors and HPPD seems to be primarily linked with the serotonin receptors, as we all know by now the 5-HT2A receptors in particular, which most modern APs have an affinity for along with the dopamine receptors. In his words, he said it would either have a positive effect for HPPD or be completely benign. In Lerner's clinical literature review, dopamine antagonists (i.e. typical antipsychotics) seem to be either helpful or benign with regards to HPPD. So, I'm hoping it helps or is benign and doesn't worsen HPPD. The only thing that surprises me is that no one has really tried it yet with HPPD, except for a few people here on the forums. I think this is because most HPPD'ers are told not to even approach APs regardless of their generation (typical/atypical), but this seems to stem mostly from experiences with only one AP, risperidone and not others. We'll see how this plays out. If there is anyone else that has tried haloperidol with HPPD, it would be much appreciated if you could give an anecdotal report of your experience, was it a success, complete failure, so-so results, etc. If it works, great. If it doesn't, well, I'll just keep on keeping on and move on to something else (likely clonidine, levetiracetam, perphenazine and a few others, definitely not levodopa though since I have an underlying psychotic condition).
  8. I've been on the cloneazepam for about 1.75 months and the lamotrigine for about 3 weeks, increasing dosage by 25mg each week until a target dose of 175mg-200mg is achieved (started at 25mg so I'm at 75mg daily right now), after which treatment is to continue for at least 12 months. Here is a short report of what has been going on so far in terms of symptoms: Improvements: Anxiety/panic is almost non-existent (as expected with the clonazepam). I'm also much more social, and to be honest, I seem to be more bold, especially with regards to the opposite sex, you know flirting and whatnot (even went on a pseudo-date with a coworker whom I'm sort of pursuing as a romantic interest ) even though I'm not the most attractive fish in the sea. Social interactions no longer scare the living shit out of me. Eye strain used to severely increase symptoms, to the point of almost being blind after sitting at my computer for a few hours. Eye strain now, while it still increases symptoms, does not worsen symptoms as severely as it did. Ghosting/double-images are reduced in intensity and seem to be only concentrated around brightly lit or colored things now (gets worse when it's really sunny out). Also it seems I have to focus on something in order to get ghosting. Can also read text on a computer screen much more easily now. Depression. Significant improvements here, while I'm still fairly depressed, I'm nowhere near where I was about 2 months ago (constantly suicidal, self harming, engaging in purposefully risky behavior, etc.) Brain fog/confusion/cognitive impairment/concentration problems. Again, much improvement here. I can think much more clearly now and no longer get frustrated when presented with a hard problem. I'm also currently participating in a research internship and am able to understand the rather abstract and hard to grasp concepts fairly easily (coworkers not so much ) Somewhat related to the depression, but I have a much more positive outlook on things now and am more optimistic and accepting about my mental/neurological disorders, of which there are 4. Symptoms lacking improvement: Image trailing. Trailing is still constant and at the same level as it was when this all started. Oscillopsia/breathing objects. I still get visual jittering (things look like they're buzzing or otherwise moving) and when there are areas of high contrast gradients/edges (light to dark/dark to light), I still get severe breathing phenomena. Palinopsia/after-images. Still get both negative and positive after-images that last about the same time as before (a few seconds to a few minutes depending on image intensity). Light beaming/beams/star-bursting. Still get long beams of light that emanate from light sources and still get starbursting around highly concentrated points of light (headlights, streetlamps, LEDs, etc.) Visual snow. Same as before. Scotomas/auras. I still get the odd scotoma/aura every one in awhile, usually at random times and usually in the form of shapeless, colorless blobs. Ghosting/double images. While there has been some improvement, it is still not to the level I would like it to be Depersonalization/derealization. While the grounding/coping techniques my psychologist taught me (and ones I came up with by myself like breath holding and cognitive interaction with my environment) help to ease and stop an attack, I still get episodes of DP/DR. ​Negative side effects: Fatigue, though this is expected with the combo of lamotrigine and clonazepam. Drowsiness and oversleeping. I have, on more than one occasion since starting this course of treatment, overslept by a large margin and either ended missing class or being late to work. Some sexual dysfunction. It's kind of difficult for me to keep and get a you know what for you know what purpose (a man has needs ). Also difficult to *ahem* sow my seed in a timely manner. Decrease in motivation to do things. While I've always been kind of a lazy person, the fatigue and drowsiness from the meds just make me want to sit down and chillout for a few hours listening to some quality tunes. Sort of a stoned, couch lock feeling. Increased appetite, though this isn't that much of a bad thing. Also, question for those who have taken this combo, is having a beer or two here and there while on these meds harmful? I do know these meds when used with alcohol increase drowsiness and decrease tolerance to alcohol, but so far I've found that small amounts of alcohol, like a light beer, don't do much. The only sort of scary experience I had was when I stupidly drank a few shots worth of high quality bourbon in a homemade cocktail. Woke up naked on top of a pile of clothes in my laundry room and not having a clue where the hell I was or how I got there. I plan to continue treatment with the lamotrigine for the recommended time of 12 months. I know it seems long, but I think it will be the key to being rid of this disease. I would also suggest lamotrigine for the people of this board. It will take awhile for it to have any sort of significant improvements on symptoms, about 6-12 months at least. The improvements I described are minor, but nonetheless hopeful for me as they tell me the medication is working and having a positive effect. I do plan on tapering off the clonazepam though as I would rather not have to deal with benzo WD on top of all this. Anyways, that's my report so far and I'll probably post another report at the end of the summer since I should be at the full 175-200mg dose of lamotrigine by then. If you have any questions, feel free to ask!
  9. Hi there! For the past two years, I have been having difficulties with video projectors, and sometimes leds. When I watched anything on a projector, the image seperated into red-green-blue trails. Usually a great sense of terror and panic attacks accompanied the visual disturbance. It was awful for me, because as an art student I am exposed to projectors constantly, and I had to give up on many of my classes because of it. It all started about a month after a very bad psilocybin experience. (I guess I haven't been exposed to any projectors in between) At the time I also experienced constant sleep paralysis, disturbing lucid dreams which started over and over when I tried to wake up... When I mentioned this to my psychiatrist, he didn't seem to care and prescribed me antidepressants and antipsychotics for my depression and general anxiety (first prozac and rexapin, then cymbalta and seroquel). I started seeing another pdoc, and it was the same with him. I told my parents about my problem (not the psilocybin experience though) and a neurologist who is a family friend suggested that I get screened for epilepsy. I went to an epilepsy expert. She wanted EEGs and MRIs which came out clear. I told about my drug use, and gave her a list of drugs I have tried over the years. She said that it must be a result of my drug use, but offered nothing to help. About 6 months ago I started seeing another pdoc. She said that some minor epileptic cases may not be diagnosed by EEGs, and prescribed me a low dose Lamictal. The main reason for Lamictal was that it acted as a mood stabilizer, but she also wanted to see if it helped with these symptoms. I started with 25 mg, around 75 mgs the visual disturbances vanished (now I'm using 200mgs but that's for the mood stabilizing effects). Well, altough I mentioned my drug use none of these doctors mentioned anything about HPPD, I guess they just don't know about it. I just found out about it myself, and after reading some articles and the posts on this forum, it seems a lot more relevant to me than photosensitive epilepsy. Still, it was treated by the instincts of my pdoc I guess I'll talk more about this with her next time we meet. What I'm curious about is, is this thing curable? Or will it return if I stop using Lamictal?
  10. Yeah, saw the psych today and got the all-hallowed script. I'm tentatively hopeful. Just a few things I'd like some insight on, if anyone can help. As far as doing a fair trial, what should I omit from my current supplement regime? It seems harmless to stick with my fish oil, multivitamin, B-complex, vitamin D3, and creatine. I've been taking ~4g of magnesium BID (morning and night), and given that the intention of that isn't purely dietary it seems logical to cut it out whilst figuring out if Lamictal suits. I'm fresh out of NAC which is probably timely as having something else affecting glutamate could potentially skew the results. If it looks like Lamictal's gonna be a long-term thing I'll probably add it back though as the "glutamate management" of NAC sounds as though it's likely to be somewhat synergistic with Lamictal's glutamate inhibition, from what I've read - there are certainly a lot of people on Lamictal who also supplement NAC on their psych's advice. I received some damiana, passiflora and skullcap by mail today and couldn't help myself - I'm vaping a mixture of damiana and passiflora right now, haha. I wasn't expecting anything this noticeable! A definite, slight warmth in my head and an overall "chilled out" feeling, with little-to-none of the distractability/poor articulation/trippiness of weed. Pretty pleasant. Is it advisable that I otherwise abstain from them while trialling Lamictal? Tapering up to even the minimum effective dose is going to take a month and it'd be nice to be able to chill out between now and then a bit, but if those wiser than me think it's not a risk worth taking I'll endure! He was really cool and semi-fudged the script so that I'm not technically taking it off-label and so can get the government-subsidised discount on it. Additionally he prescribed me 50mg despite recommending I start off at 25mg for further bang-for-my-buck, haha. Thing is, the bloody pharmacist didn't ask me if I wanted regular pills or chewable ones, and it was only after I cracked the packet open that I realised I'd wound up with the latter, which are impossible to split in half without them crumbling everywhere. I'm tempted to be cheeky and just start at 50, and if the dreaded rash begins to show I'll move back to 25. There are a bunch of reports online of people starting at 50 with no or little issue and my general impatience is making the idea very tempting. Recommendations? Finally, just a couple things I want to know in the event that I do wind up taking this for an extended period. If its effects are mild at best and I want to give keppra a shot, would it be better to taper fully off lamictal then try keppra on its own or would it be okay to start keppra whilst on lamictal? I know it's a cross-that-bridge-when-you-come-to-it situation but I can't help but speculate! Also, in response to the buzz surrounding procholinergics that coluracetam and Odisa's enthusiasm has generated, I tried choline/ALCAR/inositol a couple of times last week and the effect was definitely positive, if subtle. Is there any reason I wouldn't be able to add these on top of Lamictal down the track that anyone's aware of? How about coluracetam? I'll look into this stuff myself tomorrow but figured it was worth dipping into the collective consciousness, haha. Thanks for any responses and I hope all is well!
  11. I found this article published in June of 2013. It's definitely worth reading. I tried uploading the pdf file in research articles, but the file is too big.
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