Fawkinchit

TryingToHelp is most certainly wrong here, as he is usually about just about everything he says. Marijuana in very rare cases has caused HPPD and we have had a couple members claim that to be the case with them. So hash also could cause HPPD, being that it has a variably higher occurrence of THC. It is however extremely rare to have have hallucinations on Mari/Hash, are you sure that it wasn't some hybrid knockoff form of weed? The legal substitute compounds for related highs similar to weed have been known to cause various effects, including HPPD, and are highly untested compounds. IMO since you have anxiety coupled with visual snow and did in fact hallucinate, you likely have HPPD. It is concerning that your symptoms have been getting worse, I would highly recommend that you ask to discontinue Sertraline as it is an SSRI and it is commonly known to exasperate symptoms of HPPD, but also i would recommend the continuation of Lorazepam, as benzodiazapines appear to be the most current and best treatment known for severe HPPD. If any other members wouldn't mind pitching in here about their symptoms getting worse on SSRIs please do share as I know I have seen quite a lot. Also there are plenty of case studies on NCBI that show the same result so you can look there also. Progressive symptoms in HPPD for even up to two years is not consistent with typical HPPD, it could have been accelerated by Sertraline, and not noticed because of the Lorazepam helping the symptoms. People have even gotten palinopsia and HPPD related symptoms from only SSRI use. Anyways symptoms for the first year or so tend to get better in typical HPPD, so your symptoms are not entirely consistent. I do not feel that you have only visual snow syndrome however. Also obsessive and intrusive thoughts are not always consistent with HPPD, have you had any other related medical diagnostics done like EEGs or MRIs? Do you have any other symptoms at all that you can think of? I would recommend returning to your doctor for further diagnostics to make sure to rule out any other disorders, and/or start out by asking to discontinue SSRI use, and see where it goes from there. If you start to have any motor control issues make sure to report those to your doctor. The night blindness is also very interesting as well, as that can be simply caused by deficiencies in vitamin A. I don't know if that either is very much associated with HPPD. Basically not all your symptoms in my opinion are consistent with HPPD, but some definitely are, especially after following hallucinations from drugs use, even if it was only hash. Good luck! And give it time. Also TryingToHelp is literally learning disabled. He cant help is so just be nice to him and smile.

https://www.ncbi.nlm.nih.gov/pubmed/30910546 Maybe there are certain cases of hallucinogens depositing these protein in the brain, and maybe some people have a disorder that prevents the removal of them. As the link explains a person to developed visual snow before his CJD became serious. CJD, is a type of transmissible spongiform encephalopathy (TSE), which are caused by prions.[5] Prions are proteins that occur normally in neurons of the central nervous system (CNS). These proteins, once misfolded, are thought to affect signaling processes, damaging neurons and resulting in degeneration that causes the spongiform appearance in the affected brain.[13] The CJD prion is dangerous because it promotes refolding of native prion protein into the diseased state.[14] The number of misfolded protein molecules will increase exponentially and the process leads to a large quantity of insoluble protein in affected cells. This mass of misfolded proteins disrupts neuronal cell function and causes cell death. Mutations in the gene for the prion protein can cause a misfolding of the dominantly alpha helical regions into beta pleated sheets. This change in conformation disables the ability of the protein to undergo digestion. Once the prion is transmitted, the defective proteins invade the brain and induce other prion protein molecules to misfold in a self-sustaining feedback loop. These neurodegenerative diseases are commonly called prion diseases. People can also develop CJD because they carry a mutation of the gene that codes for the prion protein (PRNP). This occurs in only 5–10% of all CJD cases. In sporadic cases the misfolding of the prion protein is a process which is hypothesized to occur as a result of the effects of aging on cellular machinery, explaining why the disease often appears later in life.[4][15] An EU study determined that "87% of cases were sporadic, 8% genetic, 5% iatrogenic and less than 1% variant."[16] https://en.wikipedia.org/wiki/PRNP Prions protein link. This is super weird condition. Its like an infection.... but its just a protein....

The weirdest thing about this condition is that it is highly related to palinopsia, and visual snow syndrome(like oliver states), however typical cases of palinopsia usually have some degree of neuronal damage done, but MRIs for most HPPD patients mainly have normal results aside from white matter lesions, which realistically could just be demyelination

Damn bro your vast amount of evidence is really convincing! Huge claims, zero proof. Meanwhile I’ve easily and systematically proved you’re theory not only highly improbable, but also significantly ridiculous. Goodnight sweet prince shoulda hit the books before you thought you were the one lmao. you’re garbage bro

There doesn’t appear to be any methods of watching youtube videos used for the various listed forms of cortical stimulation mentioned in the study. the study however is interesting.

Oliver i think you make a good point, can you please post case studies of people getting visual snow from the list of medications you listed?

It's super necessary for you at this point. All he states is that his visuals went away and then mentions the same theory you made..... Spoiler Alert: Symptoms tend to resolve to some degree as the body heals....

I studied how to read MRIs simple as that. Might seem difficult or impossible for you, but it can be done. Also MRIs have transcript summaries from the technicians themselves that display the findings and they report what I stated, so your argument here is invalid. Drugs removing symptoms isn't proof its psychological, you have literally no idea what you're even arguing, you've clearly made up your mind before hand and just find evidence to support your preconceived idea, its called biased perspective. That argument your making actually would support it being a physiological disorder, as the drugs interact with the physical nature of the brain. In most cases I have seen there are not delays, and in the extremely rare cases they almost always take or do something to trigger it, usually being alcohol, weed, or prescriptions. That also wouldn't prove or argue psychological, as it could equally be physiological, i.e. the brain healing, or toxin buildup, swelling inflammation, a slew of arguments. I see why you are arguing what you are arguing but we are all telling you you are wrong, all mental aberrations of the brain that are not by choice are physiological derangements. There are zero signs that these patients are even unknowingly makings a choice to cause themselves extreme suffering even to the point of suicide, its a ridiculous idea, and honestly it sends the impression of your lack of knowledge of the human body and its functions, and even that of psychology. At this point if you aren't getting it you're an idiot or imbecile, and exhausting. If you find something noteworthy of sharing, or some remarkable find then share it, otherwise to continue this discussion is a waste of my time.

Just because not everyone gets it isn’t proof that its not real. Also just because you don’t get it also doesn’t prove it’s not real, here you're using biased perspective according to psychology, and its a huge flaw. Not everyone gets the flu. To be honest I'm amazed that you're still even contemplating this, I’ve shown huge flaws in your theory, I’ve also showed you various examples that give significant credence to the physiological nature of this disorder, I think you may not know what physiological means.

Cool

https://www.aafp.org/afp/2007/0801/p391.html Cyp450 https://www.ncbi.nlm.nih.gov/pubmed/30981875 https://www.ncbi.nlm.nih.gov/pubmed/15270204

You might benefit from going and reading about other conditions, all conditions relating to the brain to better understand the dilemma and complexity of the nervous system, how many things can go wrong, how much is still unknown, etc, its pretty mind blowing. It would help you understand not only the reality of this condition, but its complexity, you'll also see that not much goes on for correcting the nervous system in medical science. Only 1% of all taxes goes to scientific research, 30% goes to military, theres a reason why no advancements are being made in humanity. Edit: Also as per your friend that you mentioned I’m very sorry. Suicide rates are, from simple observation, much higher in HPPD patients than in the usual public, the condition is very serious. I would even say 80-90% of HPPD suffers contemplate the idea of suicide. Which gives a lot of credence to the reality of the condition, and could be contrasted from say, hypochondria, where they have normal suicide rates comparative to the public. Granted hypochondria is also probably physiological, as with schizophrenia, OCD, PTSD, migraines, headaches, etc.

No, i don't think that, i don't know, i was pushing for brain damage being the most logical answer, but there is contradictory evidence for that. So I’m unsure, i don’t believe those studies entirely rule out neuronal loss, but it gives credence to other possibilities.

I doubt alcohol has much impact on the neurotoxicity of MDMA.

No worries, ill lighten up lol. The first thread i edited out a lot of my posts, you can just skip to page 20, the second thread sums the 1st one up to some degree and is a lot clearer of a representation of my ideas,

You can start by reading these two threads, there are a lot of possibilities. Without doing real studies its unlikely to know for sure. I’ve been studying this condition since i got it 8 years ago. These two threads are all my reading and research and ideas accumulated. when i first started i knew very little... one finding that shows physiological evidence as to the cause are a higher than normal incidence rate of white matter hyperintensities in MRIs of patients suffering from HPPD. for a long time i assumed it must be certain that its caused by neuronal apoptosis due to some form of glutamate increase/flood, but according to some recent studies that i have posted, not all hallucingems show signs of neuronal loss even in very high doses, even 50 times usual human use. So that complicates the idea of neuronal loss.

Did you read any of the responses to your original claims? look, HPPD whether you want to believe it or not is a physiological condition, these visual disturbances are not mild, and the anxiety is far beyond that which you normally experience in normal emotional related fears. HPPD is a crippling night mare for those who have it, if you had it, you’d understand. You’re not helping anyone, if you would like to help, do actual real research and reading on possible physiological causes. to be completely blunt and honest you seem like a dreamer who envisions himself as a philosopher. I’m absolutely shocked that you claim to have a scientific related degree, i think you don’t as it appears you base your “beliefs” off imaginations instead of real observable evidence. basically, your theory is ridiculously stupid.

This isn’t a forum for drug use. Stick around and read the posts here, educate yourself, otherwise you may very well end up here.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5130561/ Vasospasm

Essentially it appears its exactly what he is implying

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6494066/ Posting this to read later, the condition could even have to do with the liver maybe. https://www.ncbi.nlm.nih.gov/pubmed/8837948 https://www.ncbi.nlm.nih.gov/pubmed/13771306 https://www.frontiersin.org/articles/10.3389/fnmol.2018.00312/full

wow, thats all really interesting because DMT/Harmaline mix did me in.

Matty O when he gets negative reviews... Were clearly not the only ones with a real condition here, if you think every person on this forum is makiing up their symptoms you’re insane, and i agree, you should definitely go talk to real doctors, they will laugh at you, just like they do the doctors of old who dismissed mental diseases like schizophrenia. You sound ridiculous, you also appear to have a severe ego complex in my opinion. also its ridiculous to sign your name in forums especially since your screen name already shows Matty, we know who you are idiot. If you want to do anything in medicine i suggest you do way more reading than just immediately jumping in to theory. ALSO, you claim facts but you provide zero evidence to support your claims. All your posts in this thread are terribly cringy. You just have a belief with no evidence, but you feel strongly about it regardless, it makes you no better than a religious fanatic.

I don't believe in cancer, it must be fake.