onedayillsailagain

Hey Kellen, the most used medication for HPPD would seem to be Clonazepam if I'm not mistaken. The increased suicide/depression risk is something you will come across with a lot of medications alas. Many of them can be a double-edged sword so to speak. If you were to take that as a excluding factor, you would limit your options to quite an extent. Fluoxetine also has the suicide/depression risk by the way. Personally I don't have much experience with Clonazepam, but others here do. The upside of Clonazepam is that it should work rather fast (minutes to hours if I'm not mistaken) compared to other medications (like Levetiracetam). The downside can be tiredness and cognitive issues, an possibly addiction, among others. Proper doctor-patient communication is important, so that if you do experience adverse effects the doctor will be able to help you before it gets out of hand. So, it's a matter of risk-benefit ratio where you need to decide for yourself how badly and quickly you need something to help. Clonazepam has been reported frequently to help with DP/DR. Other things that may help are Modafinil, yet it might not be a good idea if you have anxiety. Personally I've had the best DP/DR mitigation with tDCS, and it's a lot safer (despite the seeming scariness of applying current to your skull) than most medications. You can get this done professionally or buy/build a device yourself, however with the latter 2 options I must caution the issue of responsibility and liability again. Preferably of course you would get a professional to do so, yet financially speaking buying a device is cheaper, and building one even more so but requires some skill. The device I plan on buying myself is the Foc.us, as my DIY device wasn't always producing consistently reliable effects. That said, it is ultimately your and your doctors responsibility to decide upon what therapy is right (and safe) for you. What supplements do you use or do you have at your disposal? Have you gotten blood/hormone/organ tests lately? Ruling out dietary or metabolic deficiencies is step 1 in the process of treating mental/cognitive issues. If you're weary of medications, there are some supplements/nutraceuticals/herbs that you can consider which have been scientifically studied (never bother with unstudied stuff promoting how natural it is). At this moment I'm running a short trial with Ashwagandha to see if it helps. Some things I've found useful are Magnesium, B vitamins, and Melatonin (at night). Maybe check out Examine.com though they recently starting asking money for some of their services (was bound to happen I suppose..). Anyway, if you can give a short list of your most debilitating symptoms we might be able to recommend more specifically. All the best mate, Odisa

Well I found the best deal I could find: 100 grams total-shroom-full-spectrum-all-inclusive-you-get-the-point of Lion's Mane powder for a little under 30 bucks, here. Off-topic: And apparently I spent about the same amount on random products I don't really need, but I got some Panax Ginseng, B-12 sublingual solution, and 3 different types of nasal decongestants, among others. I got sucked in by the cheap offers.. Darn; I used to be fairly resistant to that, but it would be nice to be able to breathe better for one. Plus the $ sign seems a lot less expensive than the € sign for some reason. Apparently one of the decongestants "promotes resistance against nervous tension and excitability" whatever that's supposed to mean. But for 7 bucks I thought what the hell. Back on-topic: 100 grams will provide me with 33-50 days depending on dosage used (1g BID or TID respectively). I know I'm supposed to be all "only Keppra" for this trial I'm running, but I'm starting to care less and less about that, and might just start Lion's Mane when it arrives (I might cheat and tell myself I'm just eating a healthy fungus as if eating a vegetable soup). Rambling again..; a sign to go to bed. Cheers.

What is observed in HPPD is a shorter latency of the P2 component in the Visual Evoked Potential test, and also higher alpha frequency waves. However it may differ from person to person. Also, if I remember my basic anatomy correctly (unlikely), then the right side of the body is controlled by the left hemisphere and vice versa, Hence the locking sensation near your left temple (which coincidentally I experience as well and it's extremely annoying and uncomfortable), should not result from your left temporal abnormalities. Don't quote me on that though, but I think this is (roughly) how it works. For your next EEG, get a quantitative analysis done instead of the 'normal' analysis. This is more likely to show HPPD-related abnormalities.

Thanks for the feedback! I've yet to read more about Lion's Mane, but IIRC it would take at least a month for benefits to start being noticeable, and one study was done over a 16 week period I believe, showing good results. I can understand that in the quest of finding something that works (and preferably pretty darn acutely), that one would be inclined to cease taking Lion's Mane prematurely due to the financial obstacles. So the question remains: How long have you sustained your use of Lion's Mane and in what dosages (effective dosages are stated to range from 1-3 grams a day)?

Maybe it's just a matter of taking the correct fungus?

Lion's Mane Mushroom has putative NGF promoting properties. Interestingly, there are various accounts of improved vision across the net. Here's a proposed procholinergic mechanism through which those effects may be mediated: Lion's Mane -> NGF -> c-Fos -> epigenetic changes in ChAT transcription -> Improved/more synthesis of AcetylCholine -> see Coluracetam theory. Too tired to spell it out right now, but here are the articles from which you may connect the dots: Molecular mechanisms regulating NGF-mediated enhancement of cholinergic neuronal phenotype: c-fos trans-activation of the choline acetyltransferase gene. Nerve growth factor-inducing activity of Hericium erinaceus in 1321N1 human astrocytoma cells. Effect of an exo-polysaccharide from the culture broth of Hericium erinaceus on enhancement of growth and differentiation of rat adrenal nerve cells Yes it's all crude and icky, but hey it might provoke some thought plus my brain's in a jam today. Anyone have any experience with the stuff? I was looking into buying it but it seems ridiculously expensive and it's not the correct season to start growing them here. Whilst extracts are cheaper, they may lack the active substances. So I'll have to look around for a bit, but I'm quite eager to try this, though its effect(s) wouldn't be seen that acutely. I'm going to check my local oriental store one of these days to see if they sell dried Lion's Mane.. I read it should taste like lobster!

Ahh my bad, I meant to say "on this forum". I know of the case-reports. However, Sertraline is not so much a "true" SSRI as Fluoxetine, as it also causes some Dopamine Reuptake inhibition, and has slight Alpha Blocker characteristics, through which the improvements may have also mediated. I did see one case-report of a combination of Fluoxetine and Olanzapine, though I presume improvements were mediated via Olanzapine. In either case, I'm not saying do or don't, just that I doubt it'll help, but it might.

Came across this: Don't know if that can be regarded as funny, but didn't know where else to post it

Ok seems you know your chemistry better than I do, haha! Sounds good.. any updates?

Yeah the vomiting blood is unlikely to be related, I'd definitely get that checked out mate. Regarding the Prozac.. I can't really remember, might've discussed it in another topic, but why are you on it? I have yet to read a report of HPPD symptoms being substantially improved with SSRI's.. But there could be some lying around here, idk. Sounds like your stressed out man.. Maybe see if you can get something for that instead for the time being?

The original question: No clue what organ exercise is. However it can be assumed that if there's co-morbid anxiety or stress, giving the SNS a break can be beneficial to both body and mind. And perhaps increased oxygen flow in the brain might help, but I have no scientific sources for that conjecture. However, some evidence indicates meditation can slow Alpha waves, which were perceived to be faster in HPPD'ers, thus it may be beneficial (however I know not of the whole brainwave system, and it might be a location-specific thing, or the system may not allow for such simple equations via other differences). But that has nothing to do with "organ massaging" nor increased bloodflow to internal organs. Could we continue debating if and how meditation could benefit HPPD? Questioning is not hating, it's merely to learn and expand. Also, isn't there a case of a hypoactive PFC in HPPD, rather than a hyperactive PFC? Meditation might help, but simply applying 1.5mA to my left DLPFC helped more than any attempt at meditation I've done since having HPPD (just an observation, not a scientific claim). Also, there must be a distinction between visual improvements and co-morbid improvements, whereby meditation could help with the latter but not the former (unless someone can find some evidence on occipital responses with meditation).

Persistent palinopsia following ingestion of lysergic acid diethylamide (LSD)

I must stress that this is suspected to be via ocular improvements, not cerebral. [PDF]

Hmm I guess the anticholinergic properties of cyclizine wouldn't be that potent then, but I haven't looked it up. On a more positive note: It would appear that Ceretropic unintentionally launched their website prematurely and didn't receive my messages until I communicated by e-mail. I received an apology and a full refund. I take back my suspicions of fraudulent activity. I was also informed that their orders are limited to North America only for the time being, so if anyone is interested in pursuing such ventures, they can consider contacting Ceretropic and decide for themselves. I can't vouch for the product though, but I'm glad I received a refund without having to go through PayPal hassles. Sam93 I'd recommend you send them an e-mail as well to sort things out. Furthermore I'm currently communicating with a supplier and am able to purchase >99% pure Coluracetam. However I don't know whether this is sufficiently safe for human consumption, so I'm going through all available information once more, and I might ask for advice on this over at Longecity. Pricing was pretty decent, though the minimum order amount is 10 grams. So I'll have to procure some finances, but that shouldn't be an issue. EDIT: This patent describes the chemistry of Coluracetam in great detail (PDF - text). I'm currently reading it to see whether I can find some useful information regarding purity-safety information.

I'd supposed the kinetics of breathing with your abdomen instead of your diaphragm, could somehow affect other organs. I'd imagine that because the parasympathetic system would eventually kick in, that blood flow to intestines etc. would increase, thus deep breathing may be beneficial to other organs as well.But "massaging" is a bit vague. Anyway, no doubt meditation can help. For me personally, I breathe shallow and irregular (ever since HPPD.. strange), so meditation can be an annoying reminder that my breathing is impaired.

Thank you! Good question.. My guess is that that would depend on the type of anticholinergic, its potency, frequency, and dosage. Here's an account of Scopolamine greatly exacerbating symptoms It would appear that Ghormeh already had the same theory as mine last year, although not as extensive. Anyway, what I forgot to mention in the article is that there are cases of anticholinergic-induced HPPD (DPH and PCP for example). DPH is also reported to worsen HPPD. Another thing I wanted to add but forgot was that it could be possible that anticholinergic-(co)induced HPPD might be more susceptible to Coluracetam treatment than HPPD induced by other substances, though I would have to do some more research to make it less conjecture-ish. Care to share which anticholinergic you took without worsening of symptoms?

Cinnarizine is also known to cause acute and chronic parkinsonism [30] due to its affinity for D2 receptors, which strongly counter-suggests its actual usefulness for improving neurohealth.

Hmm I just saw Cinnarizine is OTC when I went to the pharmacy. Though I read something about how piperazines can cause parkinsonian syndrome or something like that. Anyone tried this? Indications are for balance problems. I have these, which are quite annoying if you're trying to walk (I just feel like my body is all over the place making strange choppy movements).

^Yes I did.. Mwheh blame on the brain fog, haha. Though olfactory and gustatory would seem interdependent.

Man you gotta love PGP. Makes me feel like a ninja.

Best you check over at Longecity.. Some claim L-Threonate is the best, others state it's no better than Malate and that Malate is the best. I personally use Magnesium Malate for ingestion and Sulphate for transdermal absorption. And afaik what's important with vitamins is in what form they come. For instance: Vitamin C comes in different forms, but ascorbic acid is the best (IIRC).

Yeah let me know if I messed up or forgot something, I was pretty tired nearing the end haha. Cheers!

Yeah I'm gonna figure out how to get my money back today.. Anyway, finally here's the article (download link): http://is.gd/Colu4HPPD Any and every feedback is welcome. Cheers!

You can download the entire Coluracetam hypothesis here: http://is.gd/Colu4HPPD