hppd Posted April 11, 2011 Report Share Posted April 11, 2011 It's called Memantine. It interferes with sensory gating. The disruption of sensory gating is thought to be a possible cause of HPPD. Sensory gating helps control the minds ability to focus on one sensory stimulation at a time without being overloaded. From wiki: "The cause(s) of HPPD are not yet known. The most current neurological research indicates that HPPD symptoms may manifest from abnormalities in CNS function, following the hallucinogen use. One theory derived from this research is that inhibitory mechanisms involved with sensory gating are disrupted." Also from wiki: "The mechanism of sensory gating involves feed-forward and feed-back inhibition of the stimulus perceived. It involves GABA-ergic and Alpha-7 nicotinic receptor-mediated inhibition of the pyramidal neurons in the cornu ammonis (CA3) region of the hippocampus." Memantine is an Alpha-7 nicotinic antagonist which apparently interferes with excitation of certain parts of the brain that may have been effected by hallucinogens. Gaba drugs do not appear to have an effect on HPPD. Alpa-7 nicotinic is perhaps an untested and viable target. Memantine is being tested for treatment for Generalized Anxiety Disorder, Depression, OCD and ADHD all of which share symptoms with HPPD. Has anyone tried this or know of someone who has? Memantine : http://en.wikipedia.org/wiki/Memantine Link to comment Share on other sites More sharing options...
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