joegives

Really scary short term memory issues

It didn’t in my case. I was on clonazepam for a year. It did, however create some new cognitive issues that are very slowly going away (but may be permanent)

Good find!

Hey man, really old post but wondering if you ended up trying the rife machine?

Yeah I think there’s a good chance we actually have more neuronal connections in places that aren’t meant to have them - particularly for the more psychedelic symptoms. Psychadelics have been shown to increase neuronal connections, which is why it’s becoming attractive as a treatment option for depression. but it could be a combination of the death of inhibitory neurons and a bit of the above mixed in. in any case. Not uncomplicated in the least…

Stuff like this I assume https://www.ucdavis.edu/news/psychedelic-drugs-change-structure-neurons

I've been chatting with the people at a stem cell clinic in Colorado that seems to get good results with people who have traumatic brain injuries, and I've been in touch with them. The treatment is something I'm able to afford - it's about 12,500 USD - I'd be taking it out of my mortgage - but I'm also concerned that it might make things worse because of something my psychiatrist said, which is that HPPD symptoms possibly are a result of having too many connections between neurons, and there's the risk that stem cells could get in there and strengthen those connections thinking they're fixing things. I know - a lot to take in. But if anyone has any theories about this I'd love to hear them! Hope you're all doing as best as you can. This is a mighty fucked up thing we have. Joe

Anyone heard about this? ISRIB is a small molecule that’s reversed cognitive decline in mice. I’ve read messageboards where a guy used it and felt like his working memory was increased dramatically. Potential broad applications for many neurological diseases. you can buy it on alibaba if you want to Guinea pig it might be interesting https://longevity.technology/news/calicos-memory-enhancing-drug-reverses-age-related-mental-decline/amp/

Thanks mate. A good reminder.

Where you buying it from? I might be keen

Ah - I saw in another thread - you tried it and it didn't work...4mg Bummer

do go on?

Hey man - I know it's a while since you've posted in this thread - but did you get any further with your thoughts on the etiology of it all? Would you still recommend your niacin stack - or do you think there's potentially less chance of it working if neurons are lost? or do you think it might help to regrow axons (going from the interneuron loss theory)? I've been taking the stack - it seems to help with my mood, it seems to have subdued some of the trippier elements of my visuals but not the more recalcitrant long lasting symptoms...it's only been a week though. Anyway just wondering if you're still confident that based on your most recent reading if you think it's still likely a good treatment. Oh - and love all your work mate. I'm sure I can say for everyone here that you're incredibly appreciated. Joe

All of these meds were started after I got full blown - I never needed them before. I'm on lamotrigine - I don't think it does anything...or at least what it does is very minimal. I'm also on reboxetine and mirtazapine - both of which don't help my mood as much as exercise does. I'm in the process of coming off reboxetine and mirtazapine. The clonazepam does something - or at least it did - at lower doses like 1mg which I'm currently on. But I want to come off it, because it gives me erectile dysfunction. Not nearly as badly as the reboxetine (it's so, so bad for that for me at least. Also gives me premature ejaculation). The clon also gives me memory issues.

Yeah I've heard horror stories

It gave me some more psychedelic-type movements and shifting forms that I could see on the walls if I stared at them for a couple of seconds, while muting some of the annoying peripheral movements which is my main symptom. that was at 2mg. At 1mg, it simply reduces my peripheral movement mildly (but it's lost a lot of its effect, and it's certainly not reduced to a point where I'm not severely tormented by them). I'd say I'm not a typical case though - I have BFEP - but that's the only symptom that seems to fit in with everyone else's classic symptom list. Oh and afterimages - but they never really bothered me/I never noticed them as being that big of a deal, which is why I kept using drugs and eventually gave myself full-blown HPPD

that being said - this seems to suggest that theoretically it could work: https://www.thieme-connect.com/products/ejournals/abstract/10.1055/a-1882-6802 But it does give me pause - since the article mentions that apriprazole (abilify) may be a good treatment for HPPD - which we know to not be a fact for the vast majority of people. It is also a 5HTP2a antagonist (a less pure one - it's also a partial dopamine agonist and does a few other things which may account for the worsening of symptoms) I'd imagine when it gets approved for schizophrenia in the later part of this year it'll be added to pharmaceutical benefits schemes for countries with subsidised medications programs like UK, certain countries in the EU and AUS: https://acadia.com/pipeline/

Man it's $5k for a bottle of 30 tablets in the US, and other countries where they subsidise meds (like UK and AUS - where I'm from) don't have it. So that's probably why. But as you seem pretty obsessed with it, I'm quite confused as to why you don't know this yourself. Risperidone, Abilify and Olanzepine are all 5HTPa antagonists by the way. Also Pimavanserin has a slew of worrying side effects including early death and, ironically - hallucinations

Nah it's a real shot in the dark for HPPD really, no studies. I don't think there is actually many studies proving that it's a beneficial TBI treatment as I'm looking now. The physician in charge Dr. Hughes got back to me and said it might help. Haha. So I guess it's just a ~$AUD60k maybe.

Mainly because it has paradoxical effects for me. It helps some symptoms while giving me new symptoms. But when I tried to go off it (only after one month) it increased my symptoms to much higher than they were before I started taking it. Now I'm like 9 months in and I'm like...I just don't want to be on a hectic drug like this my whole life - it's fucking shit for my memory and makes me depressed as well...

I'm going to bring this up with my psych at my next appointment on July 11. Keen to try it, though as far as I know there's only been 1 anecdotal case of it working...

I really wish I tried the 4 on/3 off method...but I went on it fulltime and now my withdrawals are hectic when I try to drop down. On 1 mg. Still on it after about 9 months, feel a bit trapped.

Man I'd love to be a part of that

All you science boffins - namely @Fawkinchit et al. I was wondering what you thought about generalised (intra-nasally administered rather than transplanted) stem cell infusions and platelet rich plasma therapy - namely the approach of the guys at this clinic in Colorado: https://tbitherapy.com/ They seem to be getting good results with traumatic brain injury patients, and I'm wondering if that benefit might translate over to those with acquired brain injuries (arguably us) that are years old (over a decade in my case - but most recent and intolerable flare-up 20 months old - before it was hardly noticeable). Plausible or nah? I've sent them an email asking their opinion, will let you know what their reply is if they ever get back to me.