Onemorestep

My first bout with hppd came from DXM actually. I had no idea what this disorder was back then though. Honestly I just waited until I felt better and sometimes with this disorder the best thing to do in the beginning is to try and let your brain heal itself and abstain from all street drugs.

all of them. 

And sleep.

HPPD can take a long time to get better but you should wait until your recovery has flatlined before trying to nudge things along. Otherwise you might do more harm than good.

that being said, you can always adopt a healthier lifestyle to try and speed things along. Eat healthy, go to the gym, socialize, start a new hobby, learn to play an instrument, etc.

its not easy for me to say this as I’m a huuuuge supporter of medications in hppd... but at the beginning your brain is in such chaos there’s no real way for anyone to make an educated guess about what’s going to help. Sometimes, before things settle down, you can even have negative reactions to things that do work later down the road. 

I’ve been doing keto for about a year and a half now and 12-18 hour fasting on and off for roughly the same time. I find both to be extremely helpful in overall health and wellness. I’m more stable and have better energy levels when I’m practicing both these things.

Thank you! As for another update—this stuff effects me strangely since I took sarcosine. Now I get side effects  headache and irritability that lasts for a week or so starting the day after injection. But it does increase my motivation which is nice. I’m more engaged with the world around me. Especially socially. The only problem is I’m an asshole. A funny asshole but still an asshole (people have told me I’m hilarious and brutal the week after taking it haha). 

Seems to give me muscle tension too. Have no idea what the MoA is for these things but they don’t seem to be permanent so that’s a good sign. 

I say it feels different after the sarcosine but it could also be a medication interaction. Bupoprion tends to make me really pissed off at the world sometimes so it might be they are working synergistically. Perhaps I will try it sans Wellbutrin when I get the chance. I find if I take very small doses (10mcg) I can retain some of the productivity benefits without rousing my ire too much. 

Ive thought of selank yea; it’s definetely on my list of things I want to try. I’m just very timid about trying new things to be honest so it takes me a while to get around to them. I’m going over to Europe from America in a few weeks and I don’t want to push the envelope should I have a nasty reaction. 

I use American research labs

On 2/12/2018 at 11:41 AM, Ngozi said:

Hey guys have you ever tried cannabis as an alternative medicine for your sick dogs? I've heard that CBD Hemp is now a thing for dogs with arthritis, compromised immune systems, stress responses, aggression and digestive issues.Well they said it was pretty safe because of the low THC, CBD hemp won’t make your pupper high.I was reading some info here about CBD here in http://www.ilovegrowingmarijuana.com/cbd-in-medical-marijuana/.I would very much appreciate any ideas and advice regarding on this issue on dogs using cannabis as an alternative herbal medicine. Thanks in advance to those who'll answer.

Cbd isolate is probably fine for dogs. Most of what I’ve read says it is. Thc however is neurotoxic to canines. So I wouldn’t use full spectrum cbd oil since that does contain thc albeit in tiny doses. Even if a full spectrum (derived from marijuana) cbd says its “thc free” it isn’t. It’s just below a certain level so they can say that. While it is very low, low enough that my hppd riddles brain can handle the amount, I can’t speak to the safety for canines. 

Long story short, if you’re going to give your dog cbd, it’s probably best to give them isolate. 

All this being said I’ve given my dog full spectrum (I didn’t know it was at the time). She seems fine! Then again how can I measure if that didn’t zap a few brain cells....

@jbalsa2 how in the world did this thread get almost 5k views in 3 days 0_o

Like to update these things periodically to report whether long term usage has been working out. So far, DSIP has been working for me but tolerance is an issue. I go on for a few days and take a week off. One thing I’ve noticed is it’s REALLY great for pain. I’ve experienced no sort of withdrawal that I’ve noticed. Here’s a link to some evidence for the reasons behind the pain relief and usage during withdrawals from alcohol and opiates:

Therapeutic effects of delta-sleep-inducing peptide (DSIP) in patients with chronic, pronounced pain episodes. A clinical pilot study.

https://www.ncbi.nlm.nih.gov/m/pubmed/6548970/

Successful treatment of withdrawal symptoms with delta sleep-inducing peptide, a neuropeptide with potential agonistic activity on opiate receptors.

https://www.ncbi.nlm.nih.gov/m/pubmed/6328354/

Yea I haven’t heard the best about mirtazepine either from those with hppd or without. It seems to be a very dirty MoA. But sometimes, dirty really works! I mean just look at keppra—that has like 6 mechanisms I can think of off the top of my head and some people achieve full remission with it. So if you find something that works stick with it I guess.

I’d suggest, based off of your negative experiences with dosage changes, that you should probably just stick with whatever dosage you’re at for a while. It might be an antagonist, but that receptor is incredibly complicated and has a ton of downstream effects. 

7 hours ago, Elendil said:

My 2 tests for Lyme disease are positive. I have Visual Snow syndrome

Oh damn man... I’m sorry to hear that. What are the doctors going to do for treatment? I’ve heard starting antibiotics should improve your situation quickly? 

Just whatever you take dont take cipro xD that’s a one way path to hell.

Good to hear Jbalsa! Let us know how it goes. Does mirtazapine interact with the 5ht2a receptor? For some reason I feel like I heard it did once. 

On 5/20/2018 at 4:37 PM, TheMythos said:

Yeah, probably. Ag isn't available in the states.

It just isnt available as a prescription. You can buy it on ceretropic I believe. I almost did last October and didn’t for whatever reason. 

On 5/19/2018 at 2:09 AM, jbalsa2 said:

@TheMythos my psych doctor is likely going to put me back on benzos for a while, and I think il use that opportunity to test out Keppra.

I've also heard success stories of people using Naltrexone, so i might also give that one a go as well.

I’ve been thinking a bit about naltrexone too. Lately I’ve been using DSIP at nights and I notice it makes me feel pretty great. One of the ways it works is my mild opioid antagonism so if that is what I’m responding to then low dose naltrexone might be nice too.

Man I was going to order some of this stuff in October and didn’t get around to it. About a month later I came across something that made me think “holy shit thank god I didn’t take that.” But for the life of me I can’t remember what it was or where I found it. I just remember knowing that I would have had a horrific reaction to it had I tried. If I can remember what it was I’ll post it.... but I’m glad to hear it isn’t doing that to you!! Remember to keep an eye on your liver

i beleive you can buy buy this in the USA from ceretropic.

Do they have the same exact MoA? I thought it was just that briv had 20 Times potency for inhibiting sv2a. We don’t know why keppra works for hppd. It might be the sv2a inhibition or it might be something completely else. My experience with researching keppra was that all the research is for epilepsy, and was centered around a few MoA for the drug. It’s possibly that keppra does other things in the brain and the pharma company wasn’t even looking there. In fact, I would say if you are correct that briv has fewer sides but is more powerful, reasoning says it probably has different moas from keppra. 

That being said, if you try one and it doesn’t work, why not try the other. 

Racetams are very weird drugs. They’ve been studied, but not enough imo. I would love to see more work done with them to create other compounds for healing.

Perhaps give uridine a shot. 

You may be right and your hppd isn’t choline based. It could be other neurotransmitters/receptors are out of whack making your current cholinergic functioning uncomfortable. I know my cholinergic receptors aren’t damaged, but my dopamine/glutamate ones are. This makes having normal levels of acetylcholine rather uncomfortable for me. Anhedonia, depressed mood, etc. no fun.

@TheMythos

coming off keppra actually made me less intelligent. Fucked my memory back to the state it was pre coluracetam/baclofen therapy. However, I think this is where my brain wants to be. I could increase my memory again through cholinergics but it makes me horribly depressed.

aminita is a cholinergic agonist I think? I think you can overdose on it and get cholinergic poisoning. One thing I’ve noticed with hppd is my cholinergic neurons don’t seem to understand homeostasis anymore. They take a very long time to go back to where they are supposed to be. If I take things that boost it, the effect is seemingly permanent for like a year or two before it returns to normal. Idk what that’s about.

@TheMythos

did quitting smoking make this worse worse right away? I keep a really steady amount of nicotine (not tobacco) in my system theorizing that the downregulation of those receptors is actually good for my symptoms.... I’m also quite addicted haha.

have you ever tried uridine? I’m just curious. It would be interesting to know if that helped or hurt. 

It definitely is something probably everyone with hppd has issues with. Hard to have high anxiety without probably having high cortisol haha.

my doctors say I’m in range though..... perhaps I’m just used to living with this crap ? 

Not sure about ataxia... funny it’s so close to ataraxia but deff not as nice...

i would love love to try topamax but my body responded so poorly to keppra I have a bit too much anxiety about it. Since I don’t know what MoA in keppra caused them, I can’t say whether top won’t do the same.

im interested to see if you’ll return to the same state as pre topamax. I know keppra seemed to have benefits for me even after I stopped.

Yea I got mine from getting nbombed too. I also experienced the muscle spasm as one of my symptoms. However, I can say that I was able to regain a significant amount of cognitive function (I could barely speak when I got hppd... it was bad.)

time, sobriety, and healthy life experiences will do a lot of good for you. I promise you, if you hang on, it will get better. I’ve been in that dark hole and know it can be difficult to believe that it will, but we are molded in the fires of adversity are we not?

In many ways, while I still suffer quite a bit (mostly through damaging my hypothalamus with drugs post acid) this was probably something that needed to happen to me. I’m doing stuff with my life I probably wouldn’t have if I had continued down the path I was on. 

I was recently looking into autoimmune stuff as I seem to suffer from several issues relating to my system.... plus my t4 levels came back pretty low. Wonder what this will bring up.

I’ll have to give this a good read when I have a bit of time. Life is a bit hectic right now with business and preparing for a long trip to Europe.

from a very brief skim... this is fascinating stuff. I’ve always thought that acetylcholine plays a pretty major role in hppd but it’s just one piece of a very complex puzzle. Drugs that effect it downstream have helped me in the past... but understanding why is more difficult.

ive unfortunately not done a huge amount of research into anticholinergic usage and issues that arise from it. The only thing I think I’ve read is it can cause damage to the basal ganglia. But that might be secondary to other disregulation and effects. I’m not sure... I can’t give you any strong suggestions for things to try. I’m a big advocate of bpc-157 and I know it has some effect on cholinergic signaling at least in the body (eyes).... but that’s kinda something I tell people to try because it’s so holistic and adaptogenic. It seems to correct a lot of different neurotransmitter systems involved in hppd. Don’t know if it will last forever but it certainly made a difference for me. I didn’t read much about it effecting many cholinergic neurons.

the interesting part is the combination of hallucinogens, dissasociatives, AND acetylcholine precursors causing a really bad time. Hppd seems to not only disregulate the 5ht2a receptor and keeping one in a “trip” state, but from my personal experience it severely diminished my glutamate receptor functioning and increased AND decreased my acetylcholine levels in different areas. The only thing I’ve found that decreases the acetylcholine is keppra and subsequent withdrawals from it. Seems to be a permanent effect. Why, I have no idea. I do know that people who have withdrawn quickly from drugs like lamictal, keppra, and benzodiazepines have complained about “cognitive issues” that I believe are related to poor acetylcholine functioning as the withdrawal from these drugs seems to have reversed the semi permanent effect of coluracetam on my brain (a high affinity choline uptake enhancer). But this is all speculation.

sorry I can’t be of more use right now. 

“The impact of agomelatine on glutamate signalling has been examined as this excitatory amino acid neurotransmitter and its receptors play a role in depression and antidepressant activity (Mitchell and Baker, 2010). Drugs with glutamate-based mechanisms are endowed with accelerated onset of activity. Currently, the non-competitive NMDA receptor antagonist ketamine appears an attractive therapeutic agent for treatment-resistant patients with depressive disorder (Machado-Vieira et al., 2009). However, the cognitive and dissociative side effects of ketamine limit its widespread application. The exact implication of glutamate in depression and antidepressant treatment is far from clear because of the many interactions with other neurotransmitter systems, for example through kinase phosphorylation and BDNF synthesis in the case of ketamine (Autry et al., 2011). A number of other drugs [e.g. selective GluN2B receptor (NR2B) antagonists, positive modulators of AMPA receptors, and metabotropic glutamate (mGlu) receptor agonists/antagonists for nomenclature see Alexander et al., 2013a] also exhibit antidepressant-like effects in animal models of depression (Hashimoto, 2011), but no clinical studies demonstrating the effectiveness of these drugs are available.

48 minutes ago, TheMythos said:

Curious what you think about the chances that this could have been placebo?

It’s never a bad thing to rule out. To me, this reads easily similar to experiences I’ve had with similar medications though. I’ve personally never experienced a positive placebo effect and find it hard to wrap my head around. One would think I would have, since I never do any kind of blind study on myself (always research as much as I can). Probably my strong negative mindset ? 

On 5/13/2018 at 0:58 PM, jbalsa2 said:

It really sucks, but the lamotrigine is noticeably working now, something i've never noticed before. I can't help but wonder if there is a connection between that overly stimulated state, and the lamotrigine actually starting to become effective. Perhaps part of the reason why it works for some but not others? Not sure, and not going to say anything thats either here nor there.

What makes me wonder now is if the lamotrigine will continue to work as it is after my symptoms return to baseline, or if it is just temporarily helping my overstimulated state. Im reluctant to say.

@jbalsa2

this is a very interesting point you bring up. I do believe that medications can feel very different if you’re in a ramped up state vs “normal”. Whenever I take a benzodiazepine drug in a overstimulated state, I feel relatively good and focused. However, if I take them when I feel “normal” or good then it just depresses my affect and I feel numb. 

I would like to look on the bright side—you can always reduce your lamictal dose to meet your current excitatory needs.

ill admit I haven’t spent a whole lot of time researching topamax. Can you tell me where the dopaminergic mechanism is coming from? The only thing I can think of is the ampa antagonization whichnis anxiolytics and the mechanism of several abusable dissasociatives that can feel pleasurable such a pcp or fycompa.

also, I can’t remember where I read this, but years ago I read a case study on hppd about a woman who tried Budapest. Her hppd was severe and she reported a worsening of certain symptoms. Probably related to its 5ht2a and downstream effects.