ChrisAUHppD13yrs

Melbourne Australia, little to know understanding doctors have had to exploit the system to find relative treatment for this problematic hppd , did however find one doctor a dr.thomas from Dandenong Cat Team at southern mental health Dandenong if anyone can find him they may get help. good luck. Chris.

I think its great guys that you are trying to improve your situation I myself am trying lions mane and feel it has had little to no effect I am taking the supplement form of course for the reasons of NGF, I have been on a myriad of medications and I think I will just throw out a warning ill probably put up a post too I am an old school hppder used to be on the old hppd board and have had hppd for around 14 yrs now, I can tell you what works and some stuff that doesn't but I would like to warn you guys about this so called NSI-189 I am not wanting to dash any ones hopes but I believe these untested chemicals especially research chemicals to be some seriously dangerous stuff I may make as post and share my thought in more detail in another post. all th3 best chris.

yes it does Work TEMPORARILY!!! the problem is after a couple of years for me 5 plus years it just stops working i was eventually upping my dose to 6mg a day! the worst side effect where: i had almost no memory short term hard to recall thing i did the day before and the withdrall is agony harder to get off than heroin much harder in my experiance it has taken me 2 yrs to slowly withdral and i mean slowly!!! its just not a long term answer unless your prepared to keep upping your dose year after year and then go horrible withdrawlls with incresed hppd, it feels great at first but like most meds it has side effects, one of the worst for me was the depressive feeling and blunt emotions whilst on it also it gave me some problems in my knee joint i belive having researched it , it can effect the absorbtion of calcium i noticed after coming off it my knee and memory returned to normal, the only problem i have now is what is another treatment option ??? Keppra kicked the crap out of my kidneys, and gave me insane rage even with the b6? HPPD sucks especially in Australia where doctors have no idea!!!

Hey Guys, Just saw this medication under :http://en.wikipedia.org/wiki/Entacapone it is called Stalevo it seams to contain a combination of the very medication DR. Abraham used in his recent trial in may with a %75 success rate? please correct me if im wrong ! i am aware that tasmar ie :Tolcopone is highly toxic to the liver and thus why it is not recommended i know i would not take it as it has crazy side effects just wondering if this combination would be better as it contains the same incredents as sinemet with what may be a corrected form or more tolerable form of Entacapone??? someone with some medical knowledge can you help me understand this would it be benificial or is entacapone just as toxic ! Quote 945. Catechol-O-Methyl Tranferase lnhibition Reduces Symptoms of Hallucinogen Persisting Perception Disorder Henry D. Abraham Psychiatry, Tufts University, Boston, MA Background: Hallucinogen persisting perception disorder (HPPD) is a poorly understood disorder arising from the use of hallucinogens. It is characterized by continuous visual disturbances which can be lifelong. There is no known treatment. Studies of HPPD patients with qEEG mapping show that the disorder is represented by disinhibition in the cerebral cortex. Inhibition of catechol-Omethyl transferase (COMT) increases inhibition of sensory input in humans carrying the G/G polymorphism. Accordingly, I hypothesized that inhibition of COMT would reduce symptoms in HPPD. Methods: A single-dose, open label trial of a tolcapone, carbidopa, and L-dopa was conducted in 17 consecutive HPPD subjects. Visual symptoms in each subject were coded on a 0 to 7 Likert scale before, and two hours after, drug administration. A paired Student t-test was used to determine statistical significance. Results: The mean pre-drug visual symptom score for the entire sample was 4.7 +l- 2.6, compared to the post-drug score af 3.7 +l- 2.8 (P= .001). A post hoc median split of the percent response of each subject was 51% symptom reduction in the upper half of responders compared to 1% in the lower half, suggesting a bimodal sample. Conclusions: Inhibition of COMT is a novel approach in the treatment of HPPD. The bimodal treatment response is consistent with the action of a functional polymorphism in the COMT gene. Future directions include a double blind, placebo controlled trial of this treament and a determination of COMT polymorphism in responders and non-responders. Keyword(s): HPPD, COMT, tolcapone, carbidopa, DOPA