StateOfRegret

LaizzesFaire: Fair enough If you ever come to any conclusion, feel free to cast a vote later on!

The statistics are already looking interesting, but we need more votes. Perhaps the usefulness is a bit hampered by there being only three categories. I would have loved to have had separate categories for empathogens, ergolines (LSD etc.), atypical psychedelics (ibogaine, salvia, ...) and dissociatives. The number of categories is, however, limited to 3 on this forum, for some reason.

Oh, and perhaps I should add that mescaline and mescaline containing cacti belong in the phenethylamine category .

Get a grip people, the last thing I want to do is ever ban someone, but this bullshit will ruin the forum and make it a place that scares off new people.

 

Seriously, put an end to this.

Couldn't agree more. It's ruining several otherwise helpful threads.

All I'm advocating - and have been advocating all along - is that everyone:

• refrains from belittling the symptoms of others
• refrains from derailing threads by posting utter nonsense.

Maybe I could have been more diplomatic, but I do admit that it gets on my nerves. This forum is a veritable goldmine - interesting thoughts and ideas are posted here every day. To see thread after thread derailed by the same person(s) is quite frustrating!

I didn't get on with Tofisopam, IIRC it made my visuals worse. I forgot/didn't realise that it was the 'only stimulant benzo', as they call it. I couldn't sleep after I took it, which was my purpose.

Perhaps the stress of not being able to sleep caused the visuals to become worse. I could try it again and make another report.

Conclusion: I slept horribly. Tianeptine didn't seem to offer me any real anxiolysis the first time around. Will be giving it another trial later.

I think I might slam my head in a hypodermic Co2 Chamber for 30 seconds of solitary confinement.. Hopefully I don't hit the "pass out mode" in return accomplishing non flickers of speckling light orbs for a temporary relief of visuals.. Could this be atomically correct anyone??

What are you talking about? That doesn't even come close to making sense. "hypodermic Co2 Chamber"? Are you just purposely derailing threads?

I'm not asking in an attempt to annoy you, I'm truly perplexed as to why you would continue doing this.

Speaking of interesting benzo-derivatives, I'd be very interested in trying tofisopam. It looks very promising, although the speculated mechanism(s) of action are a bit perplexing to me. It is marketed as an anxiolytic in some countries (Egypt among others).

It really is a mystery. Sometimes I suspect them of using some faulty probabilistic argument. I could see the line of reasoning being:

1) I've never heard of HPPD being diagnosed, then it must be rare.

2) If it is rare, then the probability of this being HPPD is very low.

3) Then other, seemingly less fitting, diagnoses are more likely.

The problem (aside from the fact that rare disorders do occur!) is that if they stick to that faulty reasoning, HPPD will forever be under-diagnosed, perpetuating the lack of familiarity with the diagnosis amongst medical practitioners .

I just took 12.5mg 10 minutes ago (23:32 in my time zone, pleasantly symmetric number ). This is the standard dose, usually taken three times daily (t.i.d.). This, however, is just a one-off trial for now. I will report back if I feel anything. All I'm feeling right now is some anxiety and wooziness - all pretty standard for me when trying new medications. I have what I guess you could call "medication anxiety".

Update:
T+63min: Nothing spectacular - nothing that couldn't be attributed to placebo. Have a slight headache and neck tension, but that isn't too uncommon for me. Feeling slightly 'high' in an indefinable way. Don't feel substantially calmer than before. Today has been one of the better days anxiety-wise, anyway.

T+68min: The real test will come once I retire to bed (quite soon), as this is usually when panic ensues.

Seems to have given me the "munchies", have eaten half a bag of crisps + some homebaked cake in the last ~15 minutes. Again, may not be due to the drug .

T+97min: Pretty calm, have a slight opioid-like sensation in body. Not sleepy at all, even though it is past 01:00.

I'm interested in hearing which class of drugs are more likely to cause/aggravate HPPD in those who take them, as well as which drugs have caused/aggravated the highest number of cases of HPPD - I hope you follow me, the distinction is a bit tricky

Anyway, please answer the best you can The choices are all of the form

"I took drug X and it was the worst"

"I never took drug X"

or

"I took drug X but other drugs were more detrimental"

ps. I know that it is a bit strange that LSD, MDMA etc are lumped together in one category - however I was only allowed to put 3 questions in the poll.

So, just to clarify: One should only choose one of the options of the form "I took drug X and it was the worst", for obvious reasons.

I was an avid drug user for 3-4 years after  I saw the first signs of HPPD, and we're talking weekly or semi-weekly use of psychedelics. My HPPD developed pretty slowly during this period, but it progressed steadily. No single drug experience has ever dramatically aggravated my HPPD the way it does for some people, though some have made more of a 'dent' in my mental health than others. If my experience is anything to go by, I'd say; stay away from phenethylamine psychedelics at all costs (2C-x, NBOMe and DOx drugs) and probably MDMA and other empathogens as well. 

Personally, I never felt that the simple (as opposed to LSD) tryptamines did much damage. In the periods where I did mainly mushrooms (psilocin/4-HO-DMT) and 4-HO-MiPT, my HPPD didn't worsen much, if at all. I know that some have gotten HPPD from mushrooms, though.

I linked to an article on benzodiazepine pharmacodynamics earlier, but odisa told me that the link is inaccessible, so I've uploaded it here:

@Sam93 : You mentioned flubromazepam. I've got my hands on a small sample of 5mg tablets, but I haven't used them yet - and I'm a bit wary due to the small amount of research into this compound. Do you still use it occasionally, and is it still as effective for you?  

File Name: An Updated Unified Pharmacophore Model of the Benzodiazepine Binding Site on GABA-A Receptors: Correlation with Comparative Models

File Submitter: StateOfRegret

File Submitted: 10 Mar 2014

File Category: Publications

A thorough discussion of benzodiazepine pharmacodynamics.

Click here to download this file

I was on the phone earlier, so posting a link to the thread was a bit of a hassle. The one I was thinking of was this thread.

Sounds great, I'm interested. I guess a few people on Longecity would be interested too, right FormerGenius?  

Hppd33: look up the etizolam thread. Lots of information in there.

May I asked why you stopped, then? Intolerable side-effects?

Did your "love-light keep burning all night long"? Haha, sorry. 

Haha! I hear they're commissioning The Grateful Dead to do the music for the TV commercials .

File Name: Translocator Protein (18 kD) as Target for anxiolytics without benzodiazepine-like side effects

File Submitter: StateOfRegret

File Submitted: 10 Mar 2014

File Category: Publications

A study on Emapunil, novel anxiolytic.
Abstract:
Most antianxiety drugs (anxiolytics) work by modulating neurotransmitters in the brain. Benzodiazepines are fast and effective anxiolytic drugs; however, their long-term use is limited by the development of tolerance and withdrawal symptoms. Ligands of the translocator protein [18 kilodaltons (kD)] may promote the synthesis of endogenous neurosteroids, which also exert anxiolytic effects in animal models. Here, we found that the translocator protein (18 kD) ligand XBD173 enhanced gamma-aminobutyric acid-mediated neurotransmission and counteracted induced panic attacks in rodents in the absence of sedation and tolerance development. XBD173 also exerted antipanic activity in humans and, in contrast to benzodiazepines, did not cause sedation or withdrawal symptoms. Thus, translocator protein (18 kD) ligands are promising candidates for fast-acting anxiolytic drugs with less severe side effects than benzodiazepines.

Click here to download this file

edit: If you like, I can see if I can find out what the pricing is on Emapunil.

That sounds very interesting! Are you saying you know of a source?   Are we talking group buy here? 

Fantastic, I'm very happy for you Looking forward to getting the chance myself, soon! Do you dose once daily @ 25mg/100mg ? 

By the way you describe it, it sounds like it could make a dramatic difference. I mean, there is a huge difference between feeling "not too out of it" and "essentially normal"

I know a woman with epilepsy who takes this, among other AEDs (anti-epilepsy drugs - it just occured to me that it could just as well stand for anti erectile dysfunction ). Will ask her about it when I get the chance. I'm always a bit wary of GABAergics, though. Any downregulation of GABA receptors is pretty detrimental.

Oh, and I believe that 1998 took (or takes?) depakote at one point. However, he hasn't been around since shortly after his doctor sent him on that completely irresponsible clonazepam cold turkey. I'm quite worried for him, actually

Glad to hear it was of some kind of use! And welcome to the forum, good to have you aboard

Then if still needed, use short term anxiety meds (benzos) to take the edge off and gain control. If the situation is too persistent/severe, then look at meds that calm the sympathetic nervous system.

What were you thinking of specifically?  β-blockers? Clonidine, guanfacine, or...?

Thanks!

AFAIK it's water-soluble. Hmm I had it standing in the sun for a bit, until I figured it might not be thermolabile yet vulnerable to UV, so I moved it out of the sun.

Now I'm running CPUminer on my laptop to raise core temperature, thus output temperature, and the GLYX-13 is now at about ~37 degrees next to it.

This better be worth melting my CPU

 

StateOfRegret: The pore size was 0.2 micron. Indeed I figured because of this, it should've passed through, but apparently that is only the case for solutions.

Haha, ingenious The water solubility is seemingly quite poor, ~2mg/mL.