Syntheso

Sorry to hear that, Dylan. That sucks. Is there anything else that might have caused the relapse? Did you start drinking more when the stressful event happened?

It seems you are concerned about fish oil? The supp I linked doesn't contain fish oil so I am not sure what your concern is. It seems the contraindication you are having is with CBD oil and fish oil.

I haven't tried the GABA supp I linked. I take Bacopa + fish oil together with no problems.

What's the best GABA supp out there that doesn't have any GABA agonism ? This is the best I can find so far; http://www.vitalityandwellness.com.au/Nutritional-Supplements/be-calm This + Bacopa which is a GABA must-have supp.

Yeah sorry mate, I've been meaning to. Also responding to your points, but am quite busy at the moment. Perhaps you could summarise what you feel are important points under headings? Would make things easier.

In the literature I have read (5-6 papers) there is no mention of a direct action on 5-HT2a receptors. I would be up for giving it a shot, I haven't as yet been able to source some. I haven't looked particularly hard though.

So do the pico-iontronic MG drops.. and the other RNA stuff on that site.. really interested in that. Edit: Doing some searches... their products seem to be bogus?

Sorry not to answer properly again... this magnesium product looks good (made by the CILTEP guys). http://naturalstacks.com/products/magtech

Cool. I will respond to everything properly later. Given you believe that you might have hypofunctional NMDAR's, why don't you do a trial of magnesium l-threonate for a month or so. This has experimentally been shown to upregulate NMDARs.

Haven't heard this mentioned. Anyone tried it? http://en.wikipedia.org/wiki/Vortioxetine Sounds interesting to me. What do you think?

Yus, indeed!

Best wishes, Jess. Hope you take lots from your experience, and good health.

I'm not quite sure. I don't recall reading anything about agonists upregulating receptors either..! Neither am I

NMDA agonists and antagonists both upregulate NMDA receptors. http://www.jneurosci.org/content/16/7/2172.full.pdf http://www.ncbi.nlm.nih.gov/pubmed/20007519 http://www.ncbi.nlm.nih.gov/pubmed/20152124 Hm. So, on the one hand NMDA antagonists upregulate the receptor they bind to, on the other, they block it.. a receptor important for learning and memory. What are we to do? I guess this is why modulators are the best shout.. or compounds they have both agonist and antagonist qualities. Magnesium L-threonate is one of the most interesting compounds I have come across - and I have had success taking up to 2g without any laxative effects. I only notice a small effect from it, but theoretically it looks like a great supp for HPPD.

Also forgot to mention I tried CILTEP (chemically induced long term potentiation) from NaturalStacks a while ago, for 3/4 days. I found it help me focus more slightly, but I found it too stimulating. Had trouble sleeping those days even though I took it first thing in the morning. Possibly slightly worsened visuals. I will try it again another time to confirm. Natural Stacks also have this; http://naturalstacks.com/products/magtech. Mmm yumm

Why don't you continue dosing (if there's not a negative)? I know the effects are meant to be rapid, but might be worth trying for a few more days? Best, S

Can you imagine?! "Yeah man, this Keppra shit is WIIILD. Totally rolling on 1,000mg. Giv'us a pick me up"

NAC has so many interesting therapeutic properties.. it seems like psychiatry's amino acid.

Updates: Doses of Mucuna Pruriens at 6g with 500mg CDP-choline 500-700mg ALCAR 2,000 mg vit C vit b complex vit D3 (cannot remember dose) 3,000mg eye q (fish oils) 1,500mg bacopa monnieri 1-3 g lion's mane mushroom mixed in a green tea 1 dopavite capsule 500-1,000mg magnesium l-threonate (before bed) 2-3 mugs of green tea a day 250mg uridine twice daily ...not quite cutting the mustard. I still can easily fall asleep in the middle of the day after spreading the above out in the morning. My focus is better than usual, when I can motivate myself. I believe things could be a lot better if I did some psychotherapy, as mentioned in another post. The point is, though, that this is all helping quite a bit, but not enough. My visuals remain the same; mild-moderate. I keep coming back to thinking about GABA, it's staring me in the face, but I am unsure how to proceed. It seems strange to think about because the main thing I am struggling with is lethargy/lack of motivation which seems to me more likely to be a dopamine issue, yet Mucuna isn't doing that much any more (I am not sure whether to increase my dose, or stop). The best ever mitigation of my symptoms was from an acute benzo dose, removing my visuals entirely for a number of hours, and restoring much of my cognitive function, at a time when it was completely defunct. I am avoiding GABA agonism as I am seeking a long term solution/recovery, so that's out of the question. GABA-wise, that leaves me with Bacopa which has been in my stack now for a while now, theoretically upregulating my GABA receptors (I should also mention that I only recently discovered it's serotonergic mechanisms which I shall include in the main post shortly) and Theanine, which I have tried before but not long term. I am looking to implement this when I next get back to my theanine supply. Inositol? I don't feel that this will be enough to give me what I am after. Even though GABA inhibits dopamine, I feel that if I enhanced it enough + the dopamine support I have already implemented, that I would function at more or less 100%; currently I feel like I am at about 80%. Quietening down some of the remaining hyperactivity is the last piece of the puzzle I feel. The question is how to do this sustainably. I am interested in compounds that enhance dopamine and GABA transmission simultaneously. I haven't found anything promising yet. On another note, I am keen to try Tianeptine, for various reasons.

Ceretropic has it back in stock (sublingual solution).

This is exciting! Hope it goes well, mate.

A sad story indeed, but, on the bright side, you seem very intelligible and mature for a 16 year old. I sense that from the way you write. Keep your head up! You are particularly young and I have confidence that you will recover if you treat your mind and body well from this point onwards.

Hey BPC. I'm not sure about that, your knowledge seems more advanced than mine to me! I will try and help though. I am merely inferring what I can from the literature.. I do not study biology formally. If something is a ‘redox agent’ it means it has the effect of changing the oxidation state of atoms, either through reduction or oxidation. In your case, we are presuming that the NMDA receptor is not functioning in a normal way (and, as I speculate, this is the case for most/all HPPD’ers). So presumably the response cannot be native, it will be altered: thus, from ‘oxidants […] depress native responses [at the NMDAR]', we cannot infer that PQQ depresses native responses. If PQQ is working for you, then we could perhaps infer that it is 'reversing the effect of a reductant', something that has ‘dramatically enhanced NMDA channel activity’ (does this mean upregulate ? ). In my thread about NMDA antagonism, I posited that perhaps there is NMDA hypofunction in HPPD, resulting in a diminished processing of traumatic memory and inability to recover from HPPD. The hypofunction could be due to a downregulation of NMDAR’s after upregulation, or another form of damage to the receptor. We could further speculate/infer from the above: Ketamine, PCP + other powerful NMDA antagonists act as reductants at the NMDA receptor. But does this make any sense, if reductants ‘dramatically enhance NMDA activity’ (NMDA antagonists presumably diminishing activity at the NMDA receptor). The thing is, we are dabbling with correlation + causation here. I am not sure we can infer relationships between NMDAR agonism/antagonism and oxidants/reductants, which is what I think you were trying to do. I think we need to dig into the literature more. At this point, I really am not sure. It would be good to discuss PQQ in relation to NAC. Quite a few people have had success with that here. It also acts the redox site of the NMDAR. Please keep us updated about PQQ.

Anyone tried it?

Sounds like things are working well for you.. keep us posted. Am interested in the BP coffee, maybe when I have some cash. I have 23andMe results but haven't looked at them in relation to Uridine. As per this thread, I began taking it, 250mg twice a day. Mainly for the modulating dopamine effects. I occasionally intermittently fast and have found it quite useful.