Syntheso

Yeah that was the impression I got, a real variety of reports. To update my point before.. it seems to me that the 'first' dose after a while (more than 5-6 hours), whilst it does keep more more focused and is anxiolytic.. it tends to bring about some brain fog, hence why some people might be put off by it. However, it does not compare to that I have experienced from HPPD, so doesn't bother me too much. It seems that if I dose TID, starting first thing and spreading the doses equally across the day, that the brain fog issue is resolved, but give me some more time to confirm that (I wasn't so strict dosing today + yesterday). Yes you are right about the GABA agonism, ScienceGuy did a thread on that at longecity, but I am not too worried, for now at least. Actually, I meant to ask you if you could post in that thread asking how long he might suggest? I got my Nefi from New Star Nootropics. Yeah I'm interested in trying that too. Going to wait a bit longer to see the effects of Nefi soley. Odisa, I was also wondering if you had any suggestions to add something to my stack for head tension.. ? I would feel more or less completely normal. Daily I take the following; Nefiracetam 150-400mg TID. Morning; 500mg Bacopa Monneiri, Vit C, B, D. Omega 3 + 6 fish oils. Evening; 1mg Guanfacine, 1,000mg Bacopa Monneiri.

Heh, I know those ones. Unless I really over-do it I often come away from those feeling fine, usually better for a while. Something about saying 'fuck it' when all your mates are going in and having a good ol' messy time.. that fun lingers !

aye! On dosing.. Definitely better to do smaller doses throughout the day (150-200/250mg). I have found that I can do a larger dose (e.g 400mg) and still have very successful results, but I don't feel more than 150mg is needed really. There appears to be no substantial added benefit. Also, I wouldn't recommend taking a large dose if you have been up for a few hours and not dosed. For example, I dosed in the evening yesterday @ 400mg without having done any in the day (I didn't dose because I had been feeling well all day). The larger dose gave me some mild brain fog for a bit, but this passed shortly and I felt good again.

I have only tried Coluracetam, which as you know I have had very positive results with . I have some Piracetam but don't really see a point in using it at the moment, esp. as it takes up to 3 weeks to really set in. Would be interesting to see what you think as you have tried quite a lot!

Okay, I have tried it.. pasting my writing from the other thread about why I wanted to try it due to the more specific title of this thread. ; For the last three days I have been taking Nefiracetam orally at doses ranging from 150-400mg TID. I have stopped taking magnesium because that would dampen, if not block its effect on the NMDA receptor that I am interested in. In short; thus far I have been feeling very good. Nefiracetam is a partial NMDA partial agonist, particularly at the glycine site. It is said to potentiate the NMDA receptor. It also has cholinergic mechanisms and is a GABA-A agonist amongst other actions. The first time I dosed, at 150mg, shortly after I experienced brain fog to the point I was drifting in and out of consciousness, like absence seizures. I have experienced this before many times with brain fog. This was accompanied by freaky sensations which I cannot quite explain.. it was like having presences around me which would sharply appear and leave my consciousness. It is how I would imagine schizophrenia to feel like, in a very mild way. I had to sleep for a couple of hours to resolve this. I have experienced this sort of thing before; I think more or less exclusively when very fatigued or having consumed alcohol whilst trying to sleep. It could have been a coincidence that this happened after ingesting Nefiracetam - but I doubt it. It could be due to its GABA action (I say this because I have experienced similarly whilst drinking alcohol). I would like to think, given my theory, that some sort of emotional processing was going on, but perhaps I am being idealistic/biased. Nonetheless, since this first dose, I have continued dosing TID and not experienced those sensations or any brain fog since. I have been feeling, as I said in short, very good. The mildest head tension; other than that, more or less like a normal, if not a more than normally motivated, person. Visuals seem to have not changed. One thing that occurs to me; Nefiracetam could be particularly useful a) because of its GABA action, which we know is very useful in HPPD simultaneously it is potentiating the NMDA receptor. These two things alongside each other are quite interesting.. maybe it would make things quite a bit worse if there was no GABA action to dampen the effect of glutamate release (which presumably Nefiracetam is doing)? The main point is that I have been dosing something that agonises the NMDA receptor and have not experienced anything negative except for my induction dose. This indicates potential for my theory, but it is still early days. I will keep updating. I am extremely confident that my experience so far suggests huge potential for d-cyclonserine and glyx-13. I would love to try them but I can't get hold of them. If anyone in London fancies meeting up for a drink, I would be more than happy to give you some of my Nefiracetam so we have another case to trial. That is, if you agree with my idea! I would also like to personally discourage use of NMDA antagonists... fair enough if they work for you, I can understand why you would take anything that mitigated the awful symptoms we experience, but I am sure there are better ways of overcoming this condition. The more and more I read about the NMDA receptor I just don't seem why on earth you would want to block it. This is just my opinion.

I have some more research to throw at this, but for now, anecdotally.. For the last three days I have been taking Nefiracetam orally at doses ranging from 150-400mg TID. I have stopped taking magnesium because that would dampen, if not block its effect on the NMDA receptor that I am interested in. In short; thus far I have been feeling very good. Nefiracetam is a partial NMDA partial agonist, particularly at the glycine site. It is said to potentiate the NMDA receptor. It also has cholinergic mechanisms and is a GABA-A agonist amongst other actions. The first time I dosed, at 150mg, shortly after I experienced brain fog to the point I was drifting in and out of consciousness, like absence seizures. I have experienced this before many times with brain fog. This was accompanied by freaky sensations which I cannot quite explain.. it was like having presences around me which would sharply appear and leave my consciousness. It is how I would imagine schizophrenia to feel like, in a very mild way. I had to sleep for a couple of hours to resolve this. I have experienced this sort of thing before; I think more or less exclusively when very fatigued or having consumed alcohol whilst trying to sleep. It could have been a coincidence that this happened after ingesting Nefiracetam - but I doubt it. It could be due to its GABA action (I say this because I have experienced similarly whilst drinking alcohol). I would like to think, given my theory, that some sort of emotional processing was going on, but perhaps I am being idealistic/biased. Nonetheless, since this first dose, I have continued dosing TID and not experienced those sensations or any brain fog since. I have been feeling, as I said in short, very good. The mildest head tension; other than that, more or less like a normal, if not a more than normally motivated, person. Visuals seem to have not changed. One thing that occurs to me; Nefiracetam could be particularly useful a) because of its GABA action, which we know is very useful in HPPD simultaneously it is potentiating the NMDA receptor. These two things alongside each other are quite interesting.. maybe it would make things quite a bit worse if there was no GABA action to dampen the effect of glutamate release (which presumably Nefiracetam is doing)? The main point is that I have been dosing something that agonises the NMDA receptor and have not experienced anything negative except for my induction dose. This indicates potential for my theory, but it is still early days. I will keep updating. I am extremely confident that my experience so far suggests huge potential for d-cyclonserine and glyx-13. I would love to try them but I can't get hold of them. If anyone in London fancies meeting up for a drink, I would be more than happy to give you some of my Nefiracetam so we have another case to trial. That is, if you agree with my idea! I would also like to personally discourage use of NMDA antagonists... fair enough if they work for you, I can understand why you would take anything that mitigated the awful symptoms we experience, but I am sure there are better ways of overcoming this condition. The more and more I read about the NMDA receptor I just don't seem why on earth you would want to block it. This is just my opinion.

Sorry to hear that mate (well, perhaps it's a good thing).. let us know how you proceed. And wishing you all the best.

Further suggestion of serotonin toxicity? See; http://hppdonline.com/index.php?/topic/1309-sleep-deprivation-helps-dp-dr Then; http://nutritionwonderland.com/2009/06/understanding-bodies-serotonin-connection-between-food-and-mood/ Study; http://www.ncbi.nlm.nih.gov/pubmed/16408408 Though, research suggests more sunlight = higher serotonin levels, and generally it seems most people with HPPD feel better in the sunlight, which contradicts a serotonin toxicity hypothesis. This also suggests otherwise. A quick look at dpselfhelp.com suggests mixed results. SSRI's have helped some whilst aggravated the condition for others. Well, the Cyproheptadine should be here soon I'll give it a whirl.

Over the last 2-3 days I have been dosing 50mg-80mg Coluracetam once/twice a day. I must say I have been feeling extremely good. In fact, the whole of last night, after I dosed 50mg and played a gig where I had to talk to various people, I had absolutely no anxiety. I was even introspectively able to think whilst talking to someone 'where's the anxiety, why don't I feel slightly weird'. Quite often I will sort of be able to have a perfectly fine conversation, but I have these little self conscious moments where I can feel my face doing strange things. Anxiety's never been a big issue for me, but there's always that little something there. It has been completely gone since I have started taking Coluracetam. I also played extremely well, despite not having practiced due to feeling shit before I introduced Coluracetam into my regime. I feel energised (it does seem to linger, I haven't dosed today and have been up doing way more than usual). In fact, I woke up really early and my body told me to get up. This is a complete reversal from me not being able to get up. My concentration and focus is through the roof right now. Better than Modafinil which if you'd spoken to me a few months ago I would have asked to be buried with (Modafinil doesn't seem to do that much for me these days, although I haven't used it and won't for a while). I can't say I notice any visual improvements yet, but that has been skewed by the fact I had my first coffee in ages yesterday, caffeine often makes things slightly pulsate visually. That is still happening today, and I can only assume it is a residue of that. But I feel good.. so what? I should also mention that it's been a couple of weeks since I started taking Full Spectrum Bacopa Monneiri (Brahmi), plus my usual stash of vitamins + fish oils; I can elucidate if anyone would like, although it hasn't changed that much from my last post in the 'Supplements That Work' thread. I have found my sweet spot with Guanfacine, only taking 1mg a day before bed. I don't think it helps me that much, but it keeps my BP where I want it, and definitely helps with hypersensitivity; it has a slightly relaxing effect. I will taper off Guan soon and see how much of a difference that makes. The only thing that persists currently, other than the visuals, is mild head tension.. I'm feeling pretty damn good right now and have been for the last few days. If that mild head tension was gone, I would feel more or less completely normal now (bar the visuals). I hope this is not just another ebb and flow, but this is definitely a very big peak. I will keep you updated... I'm afraid, whilst I am fairly disciplined, I cannot be 100% sure Colu is reponsible for everything. Like I said I have been taking Bacopa Monneiri for the last few weeks; that might be kicking in. I have been supping large amounts of omega 3 and 6 to build up fatty acids.. since then my issues with vision/driving/weirdness have gone completely (see thread in the Symptoms forum for more on that) - omega 3 + 6 are involved in the visual pathway; see brand Eye Q, recommended by my behavioural optometrist. I could also just be getting better... I might feel shit tomorrow. But I will try and be as methodical as possible and see exactly what's going to contribute to the forum, esp. Odisa's noble hypothesis. Ooops, Nefiracetam just arrived, to test my NMDA modulation theory.. hah. Must. Stay. Disciplined. When. Testing. All. These. Things. Edit: Leaving Colu for now. Want to explore NMDA modulation. Odisa, what's going on with your trial? You were doing smaller doses than me, maybe try some higher ones, you may have more success.

I heard from him recently in a PM and he said he would write a message to the community regarding his situation.

It appears to work like an SSRI. I still am not sure why SSRI's are bad for HPPD, but as posited earlier in the thread I think this could be due to serotonin toxicity, but I haven't backed that up with research yet. SJW also appears to interact with the metabolism of certain drugs which diminishes their efficacy.

Just note from my suggestion earlier in the thread, maybe 5-HTA upregulation is perhaps not what would help but downregulation. Edit: sorry just saw Odisa mentioned that.

I found an interesting study which I didn't get around to annotating today.. will post it tomorrow.

For sure. I was on Citalopram for 3 weeks with HPPD and can't say I noticed a difference, not that long for an SSRI though. It seems to be widely accepted on this board that SSRI's = bad for HPPD. I'm not sure.. I would like to know. I am saying yes possibly, but also the OP seemed plausible IIRC. Certainly some of the effects of serotonin toxicity seem to make sense in HPPD. What's interesting though is the effect of serotonin on other neurotransmitters. More on that later. Edit: Doesn't look like Ketanserin is marketed.

What about, given that people have been negatively affected by serotonin agonists/SSRI's, the idea that HPPD = too much serotonin; serotonin toxicity/serotonin syndrome. I know some people on the board have been diagnosed with that and I'm pretty sure it's been discussed a few times already. I don't understand why SSRI's would have such negative effects in HPPD if there was a lack of serotonin. They only inhibit serotonin being absorbed by the presynaptic cell, they don't agonise the 5-HT receptors... so I don't really see a potential to 'overdo it'. Maybe I'm missing something but it seems that SSRI's would only worsen things in the case of serotonin toxicity. I know they have affinity for other receptors, but these are only weak. Can anyone shed some light on that thought? I will post something more detailed on this later if poss.

Yeah agreed. I haven't yet looked into how potent it is as an antiserotonergic, but potentially quite a bit more than the usual dose to harness that aspect. I don't mind about its antihistamine effects, I have high-ish histamine and take antihistamines anyway. I have ALCAR to counteract the anticholinergic properties and/or Coluracetam. I'll send you a link to the vendor I was talking about.

nvm, read incorrectly!

I apologise, I was hasty before. I'm quite interested in trying an anti-serotonergic approach, I see the potential for it to be palliative. Any thoughts about what available antiserotonergic drugs would be best to try? As OP mentions 5-HT2a receptors make sense as the primary target. 5-HT2A antagonists[edit source | editbeta] Clozapine blocks 5-HT2A, 5-HT2C and D4 receptors. - don't like the idea of blocking dopamine receptors Cyproheptadine blocks 5-HT2A, HI and is a mild anticholinergic. - seems like the best option. Would supp procholinergic. See studies on this too. Ketanserin blocks 5-HT2A, 5-HT2C and Alpha 1 (A1) adrenoreceptors. - sounds good.. Methysergide is a 5-HT2A antagonist and nonselective 5-HT1 receptor blocker. It causes retroperitoneal fibrosis and mediastinal fibrosis - not digging the last bit... Quetiapine blocks 5-HT2A, 5-HT1A, dopamine receptors D1 and D2, histamine receptor H1, and A1 adrenoreceptors - again, don't like the idea of blocking the dopamine receptors Am working my way through list of other atypical antipsychotics that might fit the bill. This is interesting; Edit: Found some Cyproheptadine 15 x 4mg for £2.29, ordered. If anyone else wants to give it a whirl, let me know I'll send you the site (trusted vendor I have used a lot)

Great, I'll look into this.

Has anyone tried it? I'm interested because it potentiates the NMDAR's. Also has neuroprotective and anticonvulsant effects; http://www.ncbi.nlm.nih.gov/pubmed/16122714

As posited in an earlier post, a lack of Arc gene expression might explain our persistently experienced HPPD phenomena. These two studies discuss how it is induced. Noted from above, the Arc gene can be induced by Ca2+ and the cAMP messenger (+ protein kinase A and mitogen-activated protein kinase). On cAMP... See this study. Of interest it notes Guanfacine which I am currently trialing.

Small update.. I am put off by NMDA antagonists, certainly long term, due to the blocking of the NMDAR's, which are required for learning and memory. My concerns are summarised well here. I would be interested to hear some case reports from people on the board trying Memantine; another member has made a post about it in this forum. A family relative with Alzheimer's, most notably anxiolytically, has seen a huge improvement since being on Memantine. I would try myself but I am convinced that appropriate NMDA receptor modulation would be more beneficial in the long run. On a different note, on the mention of glycine.. this is interesting: I wonder why they used these forms of magnesium. Can anyone get the full text? Perhaps magnesium glycinate would be a more effective kind for us.