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Nicotinic receptors modulate the function of presynaptic AMPA receptors on glutamatergic nerve terminals in the trigeminal caudal nucleus

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α4β2-type nicotinic receptors are present on trigeminal caudal nucleus nerve terminals.

Pre-stimulation of α4β2 nicotinic receptors cause AMPA autoreceptor internalization.

The analgesic action of nicotine might depend on desensitization of AMPA autoreceptors.

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