Keppra: IL18-deficient AD mice exhibited increased excitatory synaptic proteins, spine density, and basal excitatory synaptic transmission that contributed to seizure activity. Reversed by levetiracetam.

[Onemorestep]

https://www.pnas.org/content/115/36/9002

 

IL-18 deficiency—>increased neuronal activity—>reversed by levetiracetam.

 

hallucinogens/ssri’s/cannabis/antibiotics —> alterations in neural immune system—> increased neuronal activity??