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PDE 4 inhibitor for anxiety from brain trauma


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I’ve been looking into PDE 4 inhibitors to help with the fallout from brain injury. The cause of hppd is unknown, but many believe it is partially caused by an excitotoxic event. My very limited understanding of head trauma suggest that glutamate overload contributes to the long lasting problems with head trauma..? Perhaps a drug like ibudilast could help us. I ordered some today... now just to muster the bravery to give it a shot. 

 

Thoughts?

 

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3934516/

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