kynerer Posted October 15, 2021 Report Share Posted October 15, 2021 I have read that an increase in this acid has been observed in people with mental illness, and that a decrease in it improves cognitive performance in rats. Sorry for my English. Link to comment Share on other sites More sharing options...
Fawkinchit Posted October 17, 2021 Report Share Posted October 17, 2021 My take personally is that it shows more prominence of reactive oxygen species(ROS) in people with mental disease, which is absolutely no surprise there. Its pretty clear that high kynurenic acid is just an end result of increased ROS, treating the ROS therefore would be more suitable. Its something I talk about in my threads, and there are various ways of reducing these problems. "Kynurenic acid (KYNA) synthesis along the kynurenine pathway and its mode of action. The catabolism of TRP by the enzymes TDO or IDO represents the rate-limiting step in KYNA synthesis. The intermediate metabolite kynurenine can be further processed through three distinct pathways to form KYNA, 3-hydroxykynurenine, and anthranilic acid. KYNA is formed by the irreversible transamination of KYN either via kynurenine aminotransferases (KAT I–IV) or through the action of reactive oxygen species (ROS)." Link to comment Share on other sites More sharing options...
kynerer Posted October 25, 2021 Author Report Share Posted October 25, 2021 On 17.10.2021 at 06:42, Fawkinchit said: Лично я считаю, что он показывает большую значимость активных форм кислорода (АФК) у людей с психическими заболеваниями, что здесь совершенно не удивительно. Совершенно очевидно, что высокое содержание кинуреновой кислоты - это всего лишь конечный результат увеличения ROS, поэтому лечение ROS было бы более подходящим. Я говорю об этом в своих обсуждениях, и есть разные способы уменьшить эти проблемы. «Синтез кинурениновой кислоты (KYNA) по пути кинуренина и механизм его действия. Катаболизм TRP ферментами TDO или IDO представляет собой лимитирующую стадию в синтезе KYNA. Промежуточный метаболит кинуренин может далее обрабатываться тремя различными путями до образуют KYNA, 3-гидроксикинуренин и антраниловую кислоту. KYNA образуется в результате необратимого трансаминирования KYN либо через кинурениновые аминотрансферазы (KAT I – IV), либо под действием активных форм кислорода (ROS) ». Thanks for the answer. I read your research, thanks for the work done, but shouldn't mitochondrial dysfunction affect the whole body? And how to determine the predisposition to it? We all must have something in common. Link to comment Share on other sites More sharing options...
cockmanjan Posted Thursday at 04:18 PM Report Share Posted Thursday at 04:18 PM To get the full picture, they need to conduct medical experiments about the influence of kynurenic acid and its reaction with BCAA supplements. Link to comment Share on other sites More sharing options...
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