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Hey everybody,

I am a newbie on this forum. I suffer from HPPD and I believe it is the direct result of a bad experience I had with cannabis a few years ago. I am writing a paper for a biology class on HPPD, and I want to investigate the relationship between bad trips and the development of HPPD. If anyone could point me in the direction of reliable research on this subject I would really appreciate it! I would also be open to speaking to any doctors or researchers who would not mind being quoted in my paper.

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Information on cannnabis, good vs. bad "trip", and symptoms of Depersonalization and Derealization are able to be extracted from our data in the paper:

J Clin Psychiatry. 2009 Oct; vol. 70(10) pp. 1358-64

Is depersonalization disorder initiated by illicit drug use any different? A survey of 394 adults.

Simeon D, Kozin DS, Segal K, Lerch B

OBJECTIVE: Previous studies have documented that in a substantial minority of individuals with depersonalization disorder, onset is first triggered by illicit drug ingestion. The goal of this study was to systematically compare a large sample of individuals with drug-initiated (D) versus non-drug-initiated (ND) chronic depersonalization. METHOD: We conducted an internet survey of 394 adults endorsing DSM-IV-TR depersonalization and/or derealization symptoms. Sixty-four questions were utilized to inquire about demographic and clinical characteristics, illness course, substance use history, and treatment response. The Cambridge Depersonalization Scale (CDS) was administered. The study was conducted from September 2005 to January 2006. RESULTS: Compared to the ND group (n = 198), the D group (n = 196) included more male and younger individuals. The 2 most common precipitating drugs were cannabis and hallucinogens, followed by ecstasy. The majority of participants had modest use histories prior to onset and never ingested subsequently. The 2 groups endorsed similar illness course, impairment, suicidality, and limited treatment response. The D group showed significantly greater improvement over time than the ND group (P = .002), although the groups did not differ in reported psychotherapy or pharmacotherapy effectiveness. The groups did not differ in CDS total score or on the 4 subscale scores of unreality of self, perceptual alterations, unreality of surroundings, and temporal disintegration. On the numbing subscale of the CDS, the ND group scored higher (P = .009) only prior to controlling for age and gender. CONCLUSION: The study strongly supports a uniform syndrome for chronic depersonalization/derealization regardless of precipitant.

PMID: 19538903

URL  - http://www.ncbi.nlm.nih.gov/pubmed/19538903?dopt=Citation

Send me an e-mail at davidkozin@me.com and I can forward a copy of the original.

Regarding HPPD, I think the Baggot and Erowid paper might be useful. Some version of their results are available online, but I have an updated copy and could review the results again.

My suggestion for a question which is a very good one: examine te subjective experience of the trip and any HPPD.


Sent from my iPhone

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