brendan

so bpl4296, what happened?

and more here: http://www.longecity.org/forum/topic/50102-comt-inhibitor-synergy/

some non-drug comt inhibitors discussed here: http://www.socialanxietysupport.com/forum/f11/figured-out-why-i-have-low-dopamine-high-comt-enzyme-182919/

namely 

• Rhodiola Rosea
• EGCG
• Oleuropein
• Quercetin
• Vitamin C

personally, i am a cheapskate, so i buy bulk magnesium oxide powder and neutralise it with citric acid or malic acid.  Be careful with the dosing tho, or you'll have an urgent shit a while later!

so i've been taking digestive enzymes to good effect.  But what about brain enzymes?  Could enzyme lack be a factor in hppd?  Cos i'm lazy i've pasted this paragraph from another thread which explains my enzyme background:

[enzymes, on top of my other supps make me] spectacularly clear headed and awake.  My visuals are not very severe anyway so i'm not a great guinea pig for that.  My issues are mainly brain fog/fatigue and head sensations/pressure.  I had brain fog before hppd tho, so maybe i have a leaky gut or some enzyme insufficiency so undigested food is entering my blood which is left for cellular detoxing rather than gut detoxing.  With all that crap in my system my brain maybe wasnt able to process the psychedelic experience and so hppded me from very low dose of mushrooms.  All the supps seem to have the same effect but boost each other - just clearing up my head and grounding me.  It seems strange they are so similar in effect, which suggests either they are working on the same mechanism (poss calcium-glutamate) or just different ways that just end up in generally feeling better.  But now the enzymes are so good, im thinking maybe that is the connection.  All my supps are enzyme cofactors - coincidence?

My supps after long trial and error:

vit d 5000iu

vit b bulkpowders formula (uk)

magnesium oxide (quarter teaspoon)

acetylcysteine (half teaspoon)

enzymes.

If i were to recommend one it would be the enzymes, tho the other ones are enzyme cofactors so maybe they work as a group.  I am on nattokinase, serrapeptase, and solgar digestive enzymes.  I think it is the solgar that has the most effect tho its hard to tell.

no, just spectacularly clear headed and awake.  My visuals are not very severe anyway so i'm not a great guinea pig for that.  My issues are mainly brain fog/fatigue and head sensations/pressure.  I had brain fog before hppd tho, so maybe i have a leaky gut or some enzyme insufficiency so undigested food is entering my blood which is left for cellular detoxing rather than gut detoxing.  With all that crap in my system my brain maybe wasnt able to process the psychedelic experience and so hppded me from very low dose of mushrooms.  All the supps seem to have the same effect but boost each other - just clearing up my head and grounding me.  It seems strange they are so similar in effect, which suggests either they are working on the same mechanism (poss calcium-glutamate) or just different ways that just end up in generally feeling better.  But now the enzymes are so good, im thinking maybe that is the connection.  All my supps are enzyme cofactors - coincidence?

I'm also trying c60 lipofullerene as a possible epigenetic modifier at the moment but without noticeable effect.  But maybe it will help me live past 100 like that c60 rat experiment.

My supps after long trial and error:

vit d 5000iu

vit b bulkpowders formula (uk)

magnesium oxide (quarter teaspoon)

acetylcysteine (half teaspoon)

enzymes.

If i were to recommend one it would be the enzymes, tho the other ones are enzyme cofactors so maybe they work as a group.  I am on nattokinase, serrapeptase, and solgar digestive enzymes.  I think it is the solgar that has the most effect tho its hard to tell.

Well i've still got hppd, but i feel the best i have for years.  I've been much better since discovering NAC and further improved with a few other things on top (mainly vit d, b, and magnesium).  The latest successful addition to my supplement regime has been enzymes.  I now feel totally clear headed, grounded, awake, and physically strong.  I went to a planetarium the other day without any issue at all - in the old days, all that swooping around in space would have given me vertigo anxiety.  Tho i still have the annoying wobbly head sensations and tightness; my visuals were never that bad but they havent got any better.

So there is a lot of talk about gaba, dopamine etc etc being disregulated in hppd.  Do we know this for a fact or is it just informed speculation? Is there a way of knowing for a fact - spinal tap, brain scans etc?

so initial impression is positive.  I take nattokinase and serrapeptase in the morning on an empty stomach and solgar digestive enzymes with my main meal.  It seems to improve my clarity, wakefulness and mood.  Like nac but better.  I think the digestive enzymes are the most significant but its hard to tell.  My theory is that what gives me brain fog is undigested material getting through a somewhat leaky gut. NAC helps to detox this material, but enzymes stop it in the first place.  Either that or they are stripping a load of proteinous clag that has built up in my body.  No effect on hppd itself tho.

These are the products if you are interested: from ebay uk http://www.amazon.co.uk/Serrapeptase-tablets-000IU-strength-enteric/dp/B00BUAQ7L0/ref=sr_1_fkmr1_1?ie=UTF8&qid=1389899571&sr=8-1-fkmr1&keywords=lindens+apothecary+serrapeptase

from amazon http://www.amazon.co.uk/Doctors-Best-Nattokinase-Vegetarian-Capsules/dp/B000BD0RRM/ref=sr_1_1?ie=UTF8&qid=1389899620&sr=8-1&keywords=nattokinase

from amazon: http://www.amazon.co.uk/Solgar-Digestive-Enzymes-Tablets-tablets/dp/B000Z8X3WE/ref=pd_rhf_sc_p_t_1_54H1

post here if you come across anything that may reset gene expression (given the hypothesis that hppd is result of changes in gene expression).  I'll kick off:

C60 lipofullerene (i've ordered some btw)

procaine

funny you should say that.  I just made myself a winter brew (black tea, a teaspoon of turmeric, plus about a quarter teaspoon each of whatever powders i had in the cupboard - fennel, black pepper, clove, cinnamon, ginger, cardamom) sweetened with xylitol and fattened with cream.  It tasted very nice, but was also pleased with its fortifying effect, similar but additional to nac (which is also an nmda affecting antioxidant).

Well it hurts to the tune of about £30.  I've ordered some serrapeptase, nattokinase, and solgar digestive enzymes.  Just for the craic.  Should be delivered next week.

try nattokinase for lyme?

recommended in autism.

no one else tempted to give this a go?

it doesnt have anything to do with the earth's core or magnetic field.  It is the same as when you earth an electrical appliance by wiring it to a building's plumbing system.

sorry, another one of my crap links to a subject vaguely related to hppd: http://articles.mercola.com/sites/articles/archive/2013/10/19/grounded-documentary.aspx.  The idea is to spend time with your shoes off or in other ways connected to electrical earth.  Apparently, you tend to become positively charged if you walk around with insulating shoes on, and your body needs negative charge to reduce inflammation etc.  Although it sounds a bit quacky, i can see a possible equivalence to antioxidants and alkalis which are electron donors and tend to be anti-inflammatory; also negatively charged air is more healthy (hence ionisers).  

i didnt notice anything with glycine.  I tried a superdose (cant remember what i defined as such, maybe a tablespoon or two), and it made my vision go weird - not hppd weird, but more like the blotch effect when you press your finger into the side of your eye.  It went after a while, and may have been a consequence of excess ammonia.

i did a water fast for 5 days, and felt lighter after it, but it didnt affect my hppd.  I have a semi fasting routine now, ie not eating much all day (a few bits of fruit, tea and coffee, maybe a salad or oat buscuits), then big meal around 6-7pm.  Eating makes me a bit groggy so fasting helps keep me sharp, plus its meant to be good for health.

http://www.urmc.rochester.edu/news/story/index.cfm?id=3956

dunno if it's any good, but: http://releasingptsd.com/membership-signup/?_optimizemember_seeking%5Btype%5D=page&_optimizemember_seeking%5Bpage%5D=252&_optimizemember_seeking%5B_uri%5D=Lw%3D%3D&_optimizemember_req%5Btype%5D=level&_optimizemember_req%5Blevel%5D=10&_optimizemember_res%5Btype%5D=page&optimizemember_seeking=page-252&optimizemember_level_req=10

choline bitartrate had no effect on my head pressure or any other symptom.  Alcar made me depressed.

and why does macaffee site advisor think it is a malicious site?

very interesting - how much does this goober cost?