I'll be honest, most of that went way over my head. But a few comments based on my own (extremely limited) understanding. The regions of the brain that are apparently overactive in HPPD sufferers are the occipital and temporal lobes. This seems to be similar to tinnitus (something many HPPDers experience) which shows activity in the temporal lobes caused by a loss of inhibition to auditory cortex neurons in which they 'misfire' and cause the person to hear sounds that aren't real. Is a similar misfiring causing HPPD visuals? The latest sound treatment for tinnitus is able ""reset" auditory nerve cells in the brain to stop them misfiring" and "brainwave alterations were also reversed by the therapy." It is believed that GABA drugs, which can increase inhibitory signaling, should be able to have the same effect. So in both cases could it just be the case of finding the right one?