VisualDude

Och nice I have found this tiamine version in polish. This is Pirofosforan tiaminy (Thiamine pyrophosphate). 

I've found also this information : 

And now look at this: https://en.wikipedia.org/wiki/Anticholinergic#Acute_Anticholinergic_Syndrome

I also read that antibiotics and heart drugs can cause Thiamine deficit. I took both of this, because I have hypertrophy of the right heart ventricle and also had infections.

 

But the solution cant be that simple, here is must be a something else.

Do you have a link to the actual product we can look at?

Looking at the model of severe thiamine deficiency (which puts a person in the emergency room), it is necessary to restore thiamine (obviously).  Then the person gets better over weeks/months ... but because the problem was severe, they have damage that can't be fixed.

Those here responding to TC would have mild (or perhaps moderate) deficiency.  It is difficult to know how much damage has been done.  But for sure, the brain has had to adapt to the situation of reduce energy metabolism and incorrect neurotransmitters levels and balances.  So once deficiency is being addressed, then the brain will remodel accordingly.  What the end result will be only time can tell ... but one cannot get better without addressing it.

Perhaps one can compare HPPD to surviving a plane crash.  Some walk away without any problems ... but it is unlikely that they will forget the experience...

There can be other factors and nutrients.  It would be wonderful if TC fixed everything.  Given so many responding to it on this forum - so far significantly disproportionate compared to the general population - it may be we have identified at least one common factor as to why people develop HPPD (estimated at 4% of recreational drug users).  Also, reports so far are about it helping or changing but not completely resolving all problems.

So ... you are at the beginning of a journey.  Hopefully it will help brainfog and anxiety.  If nothing else, that is significant.  And correcting thiamine deficiency will prevent further deterioration from that angle.

No specific links that I know of ... just occasional threads - most of those seem to be resolving anxiety and then the rest follows.  Also, since the med listed don't cure, its mainly a matter of time.

Anxiety, depression and fatigue are the most disabling symptoms.  Visuals, like many things in life, one may get used to.

Cocarboxylase is a chemical name, probably latin since that is most common in science.  It is thiamine diphosphate + hcl.  Many meds have hcl as a water soluable 'salt' for absoption.  You may find something under diphosphate or pyrophosphate - just read the find print because some brands talk about pyrophosphate but are just mononitrate or hcl.  See https://en.wikipedia.org/wiki/Thiamine_pyrophosphate

Don't know what companies ship to Poland but some members on this forum live there as well and may be able to assist.

Common triggers for HPPD symptoms include fatigue, marijuana, and alcohol. “Marijuana is probably the worst,” says Abraham. “For this population, it’s absolutely contraindicated. This is the kind of thing a doctor needs to tell them.” - http://dana.org/News/Details.aspx?id=43275

As for HPPD treatments ...

Dr Abraham mentions CBT as the most important thing.  It helps people develop skills to cope with the problem.  There are several aspects:

• Reducing anxiety - For many, anxiety actually makes symptoms worse ... and once they reduce it, other symptoms begin resolving.  Anxiety increases physical stress on the brain, so it is important for all to resolve it.  Anxiety can make life miserable.  Also 'panic' puts one out of control, running in circles.
• Reducing depression - which saps life of joy
• Eliminated the feeling of helplessness - 'learned-helplessness' can cause a person to give up trying.  To think in terms of black-and-white.  Life is rarely all-or-nothing, so resolving HPPD isn't likely to be either.  Knowing how one can take charge of their life in spite of problems: “Self-control is another name for changing ourselves” http://www.allto.ca/WORKSHOPS2015/WEBSCIARTICLES/WebofSciencescientificamerican0415-60Conquer.pdf
• Attention/Focus - many suffering HPPD have attention problems.  Relieving the above and further developing attention skills is important to successfully manage life

As for medications,

• Klonopin - For many it helps most symptoms.  For some it does nothing.  The downside of it is it only manages symptoms ... it does not cure.  Also, a person can quickly become dependent on it and withdrawal is difficult and a slow process.
• Keppra - A few report good results from it
• Sinemet - Some get benefit, others do not.  Dr Abraham did a drug trial with it and another med that boosts the effect and even more benefited - but it isn't a practical solution since the other med can damage the liver

You will see as you look throughout the forum, that people try many things and for some it helps but most they do not.  In the end you will have to feel your way through it and try things.

Often people get better without taking anything ... just time and 'healthy' living.

I would encourage the thiamine cocarboxylase.  What country do you live it?  Perhaps you can order it on amazon if you can't find it at stores.  It is possible that some doctors have it - many years ago some used to.  Then there are several thiamine analogs, some of which are mentioned in articles posted.  I do not have experience with them, but theoretically they should work.  The problem is that theoretically if one takes enough thiamine mononitrate it will work ... but it does not with me or some others.

You sound motivated to get better, so see what you can find where you live.  Again, you will be able to find things that will help.

Both Quercetin and Rutin are anti-thiamine, so while they are good flavonoids and anti-inflammatories, they will aggravate thiamine deficiency

Autoimmune .... Aaaauuuugggghhh ... Ouch !!! ... sorry to hear that

Don't know if it will help, but thiamine deficiency is connected with autoimmune:

• Hashimoto's - http://www.ncbi.nlm.nih.gov/pubmed/24351023
• Promotes T Cell Infiltration - http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4135011/pdf/nihms610208.pdf
• Myasthenia Gravis (autoimmune acetylcholine) - http://www.onlineholistichealth.com/myasthenia-gravis-and-thiamine/

As you may have noticed, am on a thiamine-jag  - give this a look, perhaps it will help you http://hppdonline.com/index.php?/topic/5027-thiamine-cocarboxylase/

Here is a mystery article from 1953, see if you can find it and let us know - Cocarboxylase in the therapy of myasthenia gravis - http://www.ncbi.nlm.nih.gov/pubmed/13079420

Hi Sam,

Was wondering if you still use Sinemet?

How about Gabapentin?  http://hppdonline.com/index.php?/topic/3454-gabapentin/

Been a bit since you posted.  Found something interesting and wondering if it works for many or just Sinemet people.  Give this a look when you have a moment http://hppdonline.com/index.php?/topic/5027-thiamine-cocarboxylase/  Thanks!

Otherwise, hope all is well with you in 'Sunny UK', lol

Not sure that potatoes have tryptophan or serotonin.  If I understand it, tryptophan is bound in the blood to albumin.  Then when you eat carbs, it changes the amino acid ratios, causing tryptophan to release into the brain making serotonin mediated satiation.

Ironically, potatoes do have expression of human dopamine receptors, lol - http://www.ncbi.nlm.nih.gov/pmc/articles/PMC549537/pdf/1471-2229-5-1.pdf

I've always found potatoes to be an agreeable food - lasting satiation when eating baked, boiled, or mashed.  (Hard to resist the chips though don't feel so well with them.)  Have never had negative HPPD type stuff from them.

Are you still mainly doing ketosis?  If so, could it be the switch out of ketosis?

Don't worry about that particular addiction ruining your brain.  It is a habit to deal with stress and many people do it ... it is usually only considered a mental illness if one does it in public  .  Just slowly cut back and you will feel better about yourself.

Many HPPDers recover completely in time.  Because you've had some symptoms a long time, maybe that will persist but the recent things should be reversible.

Many people with HPPD suffer attention/focus difficulties.  Some report ADD/ADHD.  All these have in common with autism dopamine issues.

Autism is a developmental nervous system disorder.  Your more recent symptoms from virus and from accident can happen to anyone ... not just autism spectrum people

There are links with autism and thiamine deficiency and treatment:

• Treatment of autism spectrum children with thiamine tetrahydrofurfuryl disulfide (Fursultiamine is thiamine analogue) - http://www.ncbi.nlm.nih.gov/pubmed/12195231
• The role of thiamine in autism - http://article.sciencepublishinggroup.com/pdf/10.11648.j.ajpn.20130102.11.pdf
• Dysautonomia in Autism Spectrum Disorder - http://www.hindawi.com/journals/aurt/2011/129795/

You could ask your doctor for a erythrocyte transketolase blood test.  But if you are just mildly deficient, it might not show.  One of those, 'don't know until you try' things.  Dysautonomia can cause the pupil fluctuations you describe - which ties in both dopamine and thiamine.

The VEP test makes sense.  PET scans do not usually reveal anything in these cases.  Even with mild autism they are subject to debate.

Are you taking any medications right now?  Are there meds you have tried in the past?

Welcome to the forum, but sorry that you are suffering.

It is possible to have the symptoms of HPPD without having used drugs.  As a technicality it wouldn't be called HPPD (because the H refers to use of hallucinagens).

Some have had it all their life.  Others develop it without knowing why. You'll find posts throughout the forum such as this one http://hppdonline.com/index.php?/topic/4550-hppd-since-childhood-without-hallucinogens/

There are other forums, typically speaking of Visual Snow, that relate much of the symptoms HPPDers have.  The mild symptoms are one thing but the progression is obviously destressing you.

Dr Abraham has spent years researching HPPD and states, "Developing HPPD without ever tripping on acid can also happen, but in my experience this is quite rare, and suggestive of another disorder in the nervous system that needs medical attention." - http://amrglobal.powweb.com/category/hppd

You describe your symptoms in several stages:

1. Visual snow and afterimages since early childhood
2. Worse symptoms following mononukleosis
3. Much worse symptoms following an accident
4. Just a little better since

This follows a pattern of a weakness that stress aggravates - similar to what Dr Abraham said.  Although you are frustrated, it is really good that various tests are all normal.  So the problem is more subtle.  

It can be as simple as difficulty absorbing something your body needs even though you eat well.  Recently have had help with a simple vitamin (thiamine) that I cannot absorb in common form - see http://hppdonline.com/index.php?/topic/5027-thiamine-cocarboxylase/  Some of your symptom indicate that possibility.  And this type of problem is easy for doctors to miss.

In time you will find an answer, or series of answers, that will help you be more normal and be able to enjoy life.  What do your doctors suggest?

Have a look at the symptoms of Acute Anticholinergic Syndrome.

Eerily familiar, huh?

Note that the '≈' sign is not a '=' sign.

I'm not saying this is true, I'm just saying I'm seeing an eerily large resemblance here.

Thoughts?

Hi again, OneDay....  Hope you are well - its been a lot of time since hearing from you

Remembered when you first posted this info.  At the time mulled and ruminated about this since there were so many things paralleling dopamine issues ... and to some extent some contradictions since PD is treated with both dopamine agonists and anticholinergics.

Finally found out that the commonality with all the symptoms you list is thiamine.  Deficiency messes with all neurotransmitters suspected, causes dysautonamic (hypothalmic) problems, cognative issues, etc.  If you get the opportunity, check out this thread http://hppdonline.com/index.php?/topic/5027-thiamine-cocarboxylase/ 

Im now on my 3rd day taking thiamine carbo 5mg in the morning.

No more brainfog after waking up, no more fatigue although I got enough sleep and increased energy level.

Its a great supplement - it makes me feel better although I smoked weed the last 3 days.

But I have to say that my HPPD is "mild" in contrast to other peoples. I dont have DP/DR, no strong brainfog (only 3-4 hours after waking up), no anxiety etc.. 

The only issues are tinnitus and the brightness at day.

I have all visuals of HPPD but that dont bothers me.

This is very good to hear ... and just 3 days so far!  More people are responding than anticipated.

My tinnitus is mild and remains the same, but brightness has changed gradual though significantly (this has been different than sensitivity).  Perhaps over time you will too.

I had a string of days feeling great. Then I accidentally left my TC at work over the weekend. Both days I went back to feeling like my old self. Yesturday took my TC again and had another great day.

Could the TC be helping the Keppra and Sinemet be effective?

Was a little surprised that after a few weeks you would feel the affects of missing it.  This makes me wonder if there is more that just a genetic conversion going on.  Certainly with myself, taking 100mg of thiamine mononitrate does absolutely nothing decernable, yet 3mg cocarboxylase does help - this would seem to be genetics.

But thinking about your experience here, decided to try 6 pills a day instead of 3 pill (9mg TC instead of 4.5mg).  I feel happier, lighter spirited, more 'connected'.  This was not expected.  Thought that after repletion, a simple maintenance would due.  The US RDA is 1.5mg/day, but that is based on young, healthy collage volunteers.  HPPD is not exactly healthy ... and I'm hardly young.

Don't know what to think about digestion issues since thiamine is supposed to help diarrhea, not encourage it.

The biggest obstacles people might face are:

• It can be very subtle, so you feel unsure of exactly how it is affecting you
• It is a change, perhaps even some initial negatives, so with change one can feel strange/unfamiliar.  HPPDers are tired of unexpected changes ... sometimes even subtle ones can be unnerving.

It would be much easier for a person to be pleased if it was a 'miracle' pill, which it is not.

Lots of reports of improved energy/fatigue.  A subtle sense of improvement.  Yet more that a placebo, as there is a repeatability.

This was posted on another thread, but copied it here because I'd like members to search for medical reports of negative effects from taking thiamine.  The only thing I can find is a person might have an allergic type of response to 100mg injection of mononitrate.  That and the general disclaimers posted that it is possible to have bad reactions to anything.  Technically a person cannot be allergic to thiamine because it is not possible to be alive without it.  But certain forms, fillers, impurities, and/or a dramatic influx could be an issue.

So if you can find negative medical info about thiamine, it might be balancing here.  For I am surprised about not being able to find bonafide negative reports.  Certainly Sinemet, Keppra, Klonopin and all other meds have downfalls.  And other vitamins such as B6 and folate have toxicity warnings about taking too much.

Certainly point #9 is valid ... and possibly a key for some HPPDers.

Valerian does loose effectiveness rather quickly.  And if you take a lot of it at once its an emetic ... a nice little addition to life.  Might take ones mind off anxiety though ...

Can fully understand not wanting to waste product

Opiods are fast like benzos ... so presume H would be.  As to killing panic instantly, don't know

I had a good morning because of the tiamine no dp or dp. After dinner I crashed now im awake again. It does something I guess, I was in a crowdy store didnt feel anxious and was pretty happy. I even had the mood to go to an electro shop. Hmm

Be sure to take (or update) the poll on thiamine, thanks  http://hppdonline.com/index.php?/topic/5124-thiamine-cocarboxylase-the-poll/

The thing about thiamine is normally a person should not need to supplement it.  So taking more should do nothing good or bad.  Yet of the few who have tried it, only Jay felt nothing, which is what happens (should say 'not happen') with most things he had tried.  And should happen if you do not need it.

Its response will be according to need:

• Quick effects = moderate to severe thiamine deficiency
• Slow effects = mild thiamine deficiency
• No effects = No thiamine deficiency (Note: it should be tried for at least a month)

The seriousness of Thiamine is significant:

1. Thiamine deficiency alters neurotransmitters (Acetylcholine, Dopamine, Gaba, Glutamate, Serotonin, +++)
2. Thiamine sufficiency means taking more will have no effect
3. There are no medical reports of serious problems from taking oral thiamine in modest amounts (even >100mg)
4. If there is any effect, good or bad, that is evidence that it is needed (see 1 and 2)
5. If the effect is good, one feels encouraged to continue taking it
6. If the effect is negative, one feels discouraged but should talk to their doctor about it since even a negative effect indicates a need
7. If it has no effect, give it at least a month
8. If a person has been thiamine deficient long enough to have neurological alterations, then it will take time (months) to fully normalize
9. If a person has a thiamine deficiency, then it is not possible to ever get well until the deficiency is resolved - this is emphatic and medically established
10. The only reason to take cocarboxylase instead of 'regular' forms is if one isn't responding to 'regular' forms.  Ironically, cocarboxylase is less toxic that regular forms

man as i mentioned above ive already been able to stop heroin use 3 years ago... i had a good time enjoying the high for 2 weeks of snorting up to 5 lines each day..then i decided to stop suddenly and had no problems....i never took it again since then ..so im definately strong enough to ride the dragon...but thats not what i was up to i said i just want to use it if i panic and i always panic if i smoke too much weed which could only possibly happen if i smoke weed and as i told you i use weed just for a week and then i take a 1 month break before i smoke again ...so maybe i wont even have the need to take it due to rare panic situations + i would only use micro doses cause im a very careful and responsible person...i was asking if anyone of you could tell me if H has the ability to kill panic

 

and i already tryed many different strains but i just want to smoke more than i could handle (rarely)...just to be really stoned once again..but then i mostly panic and this is where the H could help..a little tiny sniff maybe

 

if i dont smoke the weed it wont have an effect + the cannabinoids are mostly not dissolving in water which is just hot for a few minutes...it takes longer until it becomes orally active if you dont light it up it wont be very effective unless you do a full decarboxylation...i think smoking a little is better since im smoking cigs i can mix a few pieces into my tobacco..thats not the problem its just that i dont want to panic from higher doses or smoking more canna cigs

 

my doc didnt offer me anything she didnt seem to realize the severity of my condition at all and you are right i will try some other docs but in germany its very hard to find someone who prescribes you something really helpful if it has the potential to be abused...especially if you are young and/or have a drug past....

 

ive tryed different naturals and none of these was able to kill a panic attack....i even wonder if benzos are able to do so

 

its not that i do not appreciate your advice...but its not only that i have much experience but also know so much about drugs and myself... most people simply underestimate me...

Medical systems can be have become difficult.  More and more they are unyielding institutions - automatons in a factory.  God help a person if they are any different than standard protocol.  Am sympathetic to your frustration and efforts to self medicate.

As for weed tea, some have said they do not like the hit from smoking but like the relaxing medicinal effects of tea and eating it (brownies).  While not efficient in extracting the potential, it certainly does qualify as micro-dosing.  But if that doesn't work for you, then that is that.

If you can buy weed and heroin on the street ... why not benzos?  For years this country has been inundated with benzos and opiods being sold on the street.  Must be Germany is different.

When it comes to naturals, one just has to try them.  Thiamine cocarboxylase is a new idea I've introduced to the community ... and yes am being a little pushy about it.  No idea how it will pan out.  Just one more thing to try out.

But if you are still using weed, which is known to have the aftereffects of anxiety, it is hard to know what to say other than the replies your are receiving to discontinue.

Self medication is common.  Alcohol is the largely used to self medicate.  People are stressed out and need to chill.  Anxiety is very very common.  And street drugs are also used this way.  You seem to have made your mind up about trying heroin ... what advice are you actually looking for?

Its been a while since you've posted on this thread.  Was wondering ...

Do you still use Sinemet from time to time?

Or was the 5-10% not enough to justify it?

Am curious about whether 'dopamine' responders (strong or partial) have thiamine weakness.  If you are able, please give this a look and trial.  http://hppdonline.com/index.php?/topic/5027-thiamine-cocarboxylase/

since i cant get benzos and i just want to try something against my tripping anxiety i was wondering about trying micro doses of heroin to see if it has the ability to calm me down to normal if i experience panic while on weed or so.

 

its not that i need it unless i get panic from smoking too much weed and i dont want to get addicted which is quite easy for me..i can really hold back myself before becoming addicted...i mean i did it before my onset and i can do it again...the question is ..has H the ability to help with panic attacks

 

im asking because an old friend came to town yesterday and said it helps against anxiety and offered me the possibility to buy some..but since its quite expensive i decided to ask if anyone of you also has tripping anxiety or just random panic attacks etc. and tryed H...whats your experience...thanks in advance

 

all the best

For the most part, diamorphine (Heroin) is not used because it is very addictive.  Whereas other opiates are less so.  While moderate doses of opiates are not actually harmful to the brain, there is a prevalent lifestyle where people end up - don't think you are so strong that you won't succumb to addiction.  You may end up on the street or take high a dose and stop breathing.  Don't go there!  It is often the weakest people who reason that they are stronger than others.

If you are going to become dependent, stick with an anxiety med such as Klonopin ... if that even helps.

"smoking too much weed" is a problem.  For most, any weed is a problem.  Then there are different strains of weed.  Some are known to help 'chill' whereas others 'hype'.  If you are going to do weed (which you shouldn't), then use the strains that chill and then only make tea ... don't smoke it.  Better yet ... find legitimate help.

Jay said it well:

I am no doctor.  But it doesn't take a medical degree or psychological training to see you are in pain with anxiety and depression.

Get help today

• Find a head doc to help with CBT.  If you've done this without help, find someone else.  I'll be the first to admit that many docs are useless ... but there are some who genuinely care and help ... and just the experience of finding 'genuine' people helps
• Find a med doc to prescribe you something to take the edge off while you work through issues.  There are meds besides benzos if doc won't prescribe those - especially since you don't have visuals.  What has your doc offered you since she doesn't want to give you something addictive?  If your doctor/clinic is nearby, arrange to pickup 'addictive' benzos each day, one pill at a time - can't be abused when dispensed that way.
• Stay off recreational drugs
• Accept that you exist and just go with it
• Change your surroundings.  If you can't physically do so right now, use your mind a create a place for yourself - half of life is perspective
• Have you tried 'natural' stuff?  How about thiamine cocarboxylase ... its used to treat anxiety http://hppdonline.com/index.php?/topic/5027-thiamine-cocarboxylase/page-5#entry32380  What is there to lose but a few deutschmark ... probably cheaper than the weed you are getting, or heroin you propose to get

Anyone had any luck with anything?  I take a B complex every day and it seems to help with brain fog and give me more energy. I also take Vitamin D year round except for summer and the odd multivitamin and fish oil tablet.  I've also tried L-Theanine and it helps deepen sleep (also good for the caffeine jitters).  Pretty expensive though. 

 

I'm thinking of trying NAC?  Mainly just looking for some help in the cognitive department, although this constant "glitchy" stuff is unnerving and can go away any time it wants

Definitely had some help with B12 (methylcobalamin) - though in injection and in sublingual forms, not in B complex.  And also in conjunction with GPC and MSM.

Nothing discernible with B6/P5P (sometimes used with Keppra) or B complex

But recently had startling results with thiamine ... but ONLY cocarboxylase, NOT 'standard' forms (hcl, mononitrate).  This was not expected.  A few others have tried, usually with good results so far.  http://hppdonline.com/index.php?/topic/5124-thiamine-cocarboxylase-the-poll/

If you try it, please let us know if it helps you or not

One fellow taking 1500mg - that's a lot.  It would seem a conversion problem (genetic) to need that much.  Good to see others confirming thiamine's importance including various neurotransmitters.  Some mention they are treating excess glutamate - thiamine deficiency causes excess glutamate which causes excitotoxicity.  Part of the success of taking benzos is to reduce excess activity (GABA vs Glutamate).  Some are taking B1 analogues as well.

When treating people for DT (thiamine deficiency ... not the DTs) from alcoholism, or other forms of severe malnutrition, it is typically a 100mg injection of mononitrate.  Injection bypasses any absorption issues and gets it in quickly.  

For severe genetic disorders, it is typcially 25-75mg/day oral.  Again, mononitrate instead of using cocarboxylase.  They simply rely on 'spillover' from other pathways.  Note the diagram on bottom of post #3 http://hppdonline.com/index.php?/topic/5027-thiamine-cocarboxylase/#entry31834

If pathway [2.7.6.2] doesn't work, thiamine diphosphate [TPP] can be made through other pathways.  It just takes longer, is less efficient, and produces more intermediate metabolites.  For example, TPP can be made via [2.7.1.89] + [2.7.4.16].  Another scenario could be that [2.7.6.2] works fine but [3.6.1.15] is overactive, 'draining' TPP levels creating a milder form of thiamine deficiency.  Each pathway is controlled by genetics (blueprint) and the supply of 'raw' materials (chemicals) for each chemical step ... DNA + nutrition = life.  If a piece of the blueprint is messed up (coffee spill  ) or a chemical missing, the biological step is omitted.

They should use cocarboxylase more.  It isn't expensive and technically it is only half as 'toxic' (neither are particularly toxic).  Probably because the old procedure is deeply entrenched (typical with medicine) and it works fine ... so it isn't necessary to change.  Or maybe the half-life of thiamine is better than the phosphates?

How much are you taking now?  And is brain-fog the only thing you notice improved?

Are these the only two meds you have tried?

Noticed your post about getting thiamine cocarboxylase to try.  Hopefully you will get some good response!

Years ago tried Zoloft and anything more than 1/4 pill caused anxiety so bad I'd curl in a ball on the couch.  SSRIs tend to reduce overall dopamine.  At one time the prescribers information insert for Zoloft mentioned Parkinsonism.  They have amended it several times but some include "extrapyramidal symptoms" which is the medical term for Parkinsonism - which is most often discussed as side effects for antipsychotic (anti-dopamine) drugs.  At any rate, normally side-effects resolve when one stops taking the med ... but not always.

Here are a couple Zoloft PIs (just search: "extra")

• http://www.accessdata.fda.gov/drugsatfda_docs/label/2009/019839s070,020990s032lbl.pdf
• http://www.medicines.org.au/files/pfpzolot.pdf

So perhaps you have a dopamine weakness.  Its hard to know.  And not all SSRIs are equal.  Tried Lexapro while taking Sinemet ... no increase in anxiety but needed to double up on Sinemet.

I just ordered (Bio-3B-G) from a ebay store $16.49 free shipping . I will get it next wed, March 23.

Looking forward to seeing how you do.  Decent price ... not much more than a large pizza (depending on your preference for toppings) and its good for 1-2 months.

• “Thiamine supplementation significantly improved HARS scores, increased both appetite and general well-being, and reduced fatigue in patients with GAD”

• "For anxiety, thiamine has been used successfully at doses of 250 mg/day to treat patients with anxiety disorders"
• "Twenty-six patients with Leigh’s disease responded to high intakes of thiamin, doses ranging from 20 to 3000 mg/day. In two sisters, lipoic acid (100 mg/day) plus thiamine (3000 mg/day) provided the best remediation."

• “It is our opinion that fatigue, sleep disorders, depression, anxiety and cardiac troubles are the expressions of a classic mild thiamine deficiency”

• "All the patients also showed the other clinical manifestations of mild thiamine deficiency, such as sleep disorders, depression, anxiety, mood fragility, memory loss, attention disorders, lack of tolerance to stress, frequent lack of appetite, episodes of tachycardia and extrasistolia, generalised muscular weakness, muscular cramps, calf and feet sole pain, temperature-variation intolerance and dry skin."
• "The patients moreover reported an almost complete disappearance of fatigue-related symptoms such as an improvement of the intolerance to heat variations, sleep disorders, depression, anxiety, irritability, dry skin, lower leg swelling and tachycardia."

Could the TC be helping ... Sinemet be effective?

It will be interesting to see if TC responders are dopamine responders.  For example, Jay is not a dopamine responder and TC did nothing at all for him either.  Where as Merkan and I respond to both.

Here are a couple links showing commonality between thiamine and dopamine (via Parkinson's):

• Article http://onlinelibrary.wiley.com/doi/10.1111/cns.12078/full
• List of genes/factors http://www.jns-journal.com/article/S0022-510X(12)00068-8/abstract

However, Thiamine affect ALL nerve cells - therefore more than dopamine is involved

"thiamine derivatives control the number of functioning ionic channels by stabilising the density of negative surface charges at the inner side of the nerve membrane" http://www.ncbi.nlm.nih.gov/pubmed/1148850

1. thiamine diphosphate or thiamine triphosphate are the active thiamine compounds in nerve membranes; 
2. the site of action is located at the internal suface of the membrane; 
3. the reduction of the thiamine concentration in the membrane or in the axoplasm could cause the exponetial decline of currents; 
4. the release of thiamine from nerve membranes induced by tetrodotoxin is interpreted as a side effect not even related to the mechanism by which tetrodotoxin blocks the sodium channels; 
5. thiamine polyphosphates appear to stabilise the intrinsic electric field strength of the nodal membrane in the resing state. 

Yes, it has been suggested that taking B6 will reduce "Keppra rage" that some people experience.  Also, it is best for 'B's to be supplemented together - particularly when taking large amounts.

I had a string of days feeling great. Then I accidentally left my TC at work over the weekend. Both days I went back to feeling like my old self. Yesturday took my TC again and had another great day.
Could the TC be helping the Keppra and Sinemet be effective?

• For either stress or malnutrition, any form of thiamine should be sufficient
• For cocoarboxylase to be superior, there must be genetic weakness
• Recently it has been observed that some people suffer a genetic thiamine weakness, but the genes involved have not yet been identified
• No reports about B-complex significantly helping HPPD (please search and correct if I’m wrong)
• Taking modest amounts of thiamine should do absolutely nothing, good or bad
• Only 10-20% of population should need thiamine supplementation
• Only serious illness from serious deficiency responds quickly to thiamine
• If a person responds quickly, it can only be due to significant need
• Yet – so far – HPPD response has been > 10-20%
• It is known that many HPPDers have dopamine issues - 1/3rd responded to Dr A’s trial
• It is known that dopamine issues have thiamine issues
• HPPD is sometimes recurrent without taking drugs again
• HPPD is sometimes progressive, possibly indicating neurological stress/weakness
• Thiamine is used by all neurons and HPPD involves many neurons
• Both present “weird psychiatric and neurological” problems

• Many people will have to try TC
• They need to post their results
• Those who respond need to report response over time  – 24hour, 1 week, and 1 month
• They also need to try ‘regular’ forms of thiamine and report whether they respond to that or not
• This info will need to be collated for presentation

You need a "had no effect" otherwise the poll will seem a bit skewed as more people try

There you go.  Thought most people would have been 'did nothing' as you experienced ... figuring only 10% having positive response.  Time will tell if more people try it and give feedback.

Probably should have divided it two with one list of 20 visual problems helped and the same list of 20 visual problems made worse, with did nothing at all separately.  So the one guy who got more energy but worse DR and VS could poll it that way.  Then there is the runs at higher amounts ....  Its kind of hard to know how to set these polls up well ... but a summary of the Good, the Bad, and the Ugly is always helpful.