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David S. Kozin

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Posts posted by David S. Kozin

  1. Neurontin can cause a high, and talked with some other who use it. I currently take Gabapentin and have for a very long time. It does have withdrawals at higher doses, but manageable. It is very effective and rapid effect of reducing "anxiety to complete an action." such as visiting the message board. It is stressful when I have not been on for some time because of my personal situation, and without gabapentin I would feel overwhelmed to come back. It lowers an anxiety overthinking threshold. That being said, during the days I was very involved with drug use, I knew people trading a single pill of Ecstasy for an 800 mg of Gabapentin. We always tried to get our hands on gabapentin. I believe i could run a controlled study with users of cocaine (very infrequent, but for social reasons) and have it paired with Gabapentin and see most coke users switch.

    It is also abused as a recreational drug in prisons at high doses. I do notice that my body is much less affected by cold at higher doses as well.

    - David

  2. The definition of HPPD has changed since the DSM-IV-TR was developed, and essentially has taken to mean any chronic persisting altered visual experience caused by hallucinogen, non-hallucinogen psychoactive drug, toxin, trauma, and unexplained. Opiates could cause altered visual experiences, and also the reason you were taking the opiates for a year likely involved some stress on your body and other aspects of your biological/psychological experience.

    I dislike "HPPD" as a name because it is okay if the clinical community would only use it for hallucinogens, but the other problem is the definition of a hallucinogen. Take enough opiates and you will hallucinate, and amphetamine is not a hallucinogen but withdrawal off amphetamine (higher dose/longtime) produces hallucinations.

    ANSWER: It is possible that codeine caused your symptoms, but I would also consider the state your body was in as a whole and anesthesia and antibiotics have been associated with these visuals.

    Sincerely,

    David

  3. I have so many articles named fulltext(x).pdf where x is any value from NULL to 400 or so. Additionally, many of the articles download with a number sequence. I am working through the articles and placing them in appropriate category/etc not only for this purpose but for a project.

    I have completed an audio version of my HPPD plan I wrote, and working that with programs to break it up into sections and put it up on the visiondisorders.org web site.

    - dk

  4. I have a full copy of the paper, but because it was just published I am going to hold off on disseminating it, but not to worry you are not missing much unless you took Math to Linear Algebra or Differential Equations. The publication is exciting because it comes from new researchers from a new perspective: Computational Neuroscience.

    J Comput Neurosci. 2012 Feb;32(1):25-53. Epub 2011 Jun 14.

    [/left]

    Hallucinogen persisting perception disorder in neuronal networks with adaptation.

    [/left]

    Source

    Department of Mathematics, University of Pittsburgh, Pittsburgh, PA, 15260, USA, zpkilpat@pitt.edu.

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    Abstract

    We study the spatiotemporal dynamics of neuronal networks with spike frequency adaptation. In particular, we compare the effects of adaptation being either a linear or nonlinear function of neural activity. We find that altering parameters controlling the strength of synaptic connections in the network can lead to spatially structured activity suggestive of symptoms of hallucinogen persisting perception disorder (HPPD). First, we study how both networks track spatially homogeneous flickering stimuli, and find input is encoded as continuous at lower flicker frequencies when the network's synapses exhibit more net excitation. Mainly, we study instabilities of stimulus-driven traveling pulse solutions, representative of visual trailing phenomena common to HPPD patients. Visual trails are reported as discrete afterimages in the wake of a moving input. Thus, we analyze several solutions arising in response to moving inputs in both networks: an ON state, stimulus-locked pulses, and traveling breathers. We find traveling breathers can arise in both networks when an input moves beyond a critical speed. These possible neural substrates of visual trails occur at slower speeds when the modulation of synaptic connectivity is increased.

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