David S. Kozin
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Posts posted by David S. Kozin
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Related Articles LSD-induced Hallucinogen Persisting Perception Disorder treated with clonazepam: two case reports.
Isr J Psychiatry Relat Sci. 2001;38(2):133-6
Authors: Lerner AG, Skladman I, Kodesh A, Sigal M, Shufman E
Benzodiazepines are recommended for the treatment of Hallucinogen Persisting Perception Disorder (HPPD), although it is unclear which may be more helpful. Two out-patients with LSD-induced HPPD were successfully treated with clonazepam. They had not responded to low potency benzodiazepines or low doses of classic antipsychotics. After clonazepam discontinuation they reported a marked improvement and only mild symptomatology which persisted during a six month follow-up period. High potency benzodiazepines like clonazepam, which has serotonergic properties, may be superior to low-potency benzodiazepines in the treatment of some patients with LSD-induced HPPD.
PMID: 11475916 [PubMed - indexed for MEDLINE]
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All file uploads will generate topics, and a special Category/Section will be created for this purpose.
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File Name: Current Opinion of Psychiatry: HPPD, a differential diagnosis.
File Submitter: David S. Kozin
File Submitted: 18 Oct 2010
File Category: HPPD Research Articles
A response to a case report with symptoms similar to HPPD.
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I have resources that should be helpful. I work with a treatment team in an acute inpatient co-occurring dual-diagnosis substance abuse unit with a conselor with a similar degree program. Having front line clinical specialists with knowledge on drug-induced disorders is always a major bonus.
We are working on the research you are describing and will be glad to help with references and material. Science is to be shared and it isn't about who gets excusilve rights to do it, but the more validation we can accomplish the better the results in the end.
Best,
David
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I discovered an iPhone application for this Board that is native to the iPhone! Alas, I can do something.
Yes, the GoDaddy template site I had created was before I knew of a solution.
This morning,, I am reading about d-LSD's affect on genetic expression of 5-HT receptor regulation of GABAergic inhibitory neurons. Examining disorders that occur when the 5-HT2A receptor is in lower concentrations than normal in this system.
I am working from 3 - 11:30 pm Today, Tomorrow, Saturday, and Sunday.
I am trying to extract the email list from the old board to send out a broadcast message, but believe that it may also be good to let members continue their break until they feel necessary to try the HPPDonline.com web address again. Addittionally, AlteredPerceptions.com is in my hands and will point to the site.
Update: I am submitting a research proposal to the IRB to allow me to collect case histories from members with their approval, and administer a new research instrument over the phone to begin to validate the theory presented in my thesis. It would be powerful for the reader to hear life stories and how this disorder has affected their lives.
I am consulting with Dr. Davis on the forum set-up, and I will be uploading files on HPPD.
The positive attitude towards accepting change from the both of you is refreshing.
All my best,
David
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NEW ORLEANS -- Relapse rates for patients with treatment-resistant major depression were much lower following transcranial magnetic stimulation (TMS) than is normally seen with drugs or electroconvulsive therapy, researchers said here.
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NEW ORLEANS -- Relapse rates for patients with treatment-resistant major depression were much lower following transcranial magnetic stimulation (TMS) than is normally seen with drugs or electroconvulsive therapy, researchers said here.
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NEW ORLEANS -- Neither obesity nor simple overeating will be included in the DSM-5, the forthcoming revision to the Diagnostic and Statistical Manual of Mental Diseases, but binge eating is on track to become a formal psychiatric diagnosis, it was reported here.
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NEW ORLEANS -- Neither obesity nor simple overeating will be included in the DSM-5, the forthcoming revision to the Diagnostic and Statistical Manual of Mental Diseases, but binge eating is on track to become a formal psychiatric diagnosis, it was reported here.
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NEW ORLEANS -- As psychiatrists work to bring the Diagnostic and Statistical Manual of Mental Diseases (DSM) up to date, no category is likely to see more sweeping changes -- in nomenclature at least -- than sleep disorders.
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NEW ORLEANS -- As psychiatrists work to bring the Diagnostic and Statistical Manual of Mental Diseases (DSM) up to date, no category is likely to see more sweeping changes -- in nomenclature at least -- than sleep disorders.
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NEW ORLEANS -- Youngsters who were disruptive in school improved significantly after a school-based program that taught behavioral self-control through the use of puppets, researchers said here.
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NEW ORLEANS -- Youngsters who were disruptive in school improved significantly after a school-based program that taught behavioral self-control through the use of puppets, researchers said here.
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NEW ORLEANS -- The atypical antipsychotic aripiprazole (Abilify) appears to be safe for longer-term treatment of irritability associated with autism, but patients are at an increased risk of weight gain, researchers said here.
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NEW ORLEANS -- A once-monthly injection of naltrexone (Vivitrol) kept more patients off opioids than did placebo, researchers reported here.
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NEW ORLEANS -- A once-monthly injection of naltrexone (Vivitrol) kept more patients off opioids than did placebo, researchers reported here.
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NEW ORLEANS -- A potentially less stigmatizing name isn't likely to put the controversial designation of "psychosis risk syndrome" into the fifth edition of the Diagnostic and Statistical Manual of Mental Diseases (DSM-5), a researcher suggested here.
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NEW ORLEANS -- A potentially less stigmatizing name isn't likely to put the controversial designation of "psychosis risk syndrome" into the fifth edition of the Diagnostic and Statistical Manual of Mental Diseases (DSM-5), a researcher suggested here.
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NEW ORLEANS -- Poor mental health may result in physical problems for relocated survivors of Hurricane Katrina, researchers reported here.
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NEW ORLEANS -- Poor mental health may result in physical problems for relocated survivors of Hurricane Katrina, researchers reported here.
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NEW ORLEANS -- Proving that the request for public comments on proposed revisions to the psychiatry profession's main diagnostic manual was not just window-dressing, a number of changes have already been incorporated, officials of the American Psychiatric Association indicated here.
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NEW ORLEANS -- Proving that the request for public comments on proposed revisions to the psychiatry profession's main diagnostic manual was not just window-dressing, a number of changes have already been incorporated, officials of the American Psychiatric Association indicated here.
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NEW ORLEANS -- Exposure therapy using virtual reality appears to be more effective for alleviating symptoms of post-traumatic stress disorder (PTSD) than traditional treatment among members of the military who have served in Iraq or Afghanistan, researchers said here.
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NEW ORLEANS -- Exposure therapy using virtual reality appears to be more effective for alleviating symptoms of post-traumatic stress disorder (PTSD) than traditional treatment among members of the military who have served in Iraq or Afghanistan, researchers said here.
EEG coherence in post-LSD visual hallucinations.
in Research Articles, Publications and Studies
Posted
EEG coherence in post-LSD visual hallucinations.
Psychiatry Res. 2001 Oct 1;107(3):151-63
Authors: Abraham HD, Duffy FH
LSD use in certain individuals may result in chronic visual hallucinations, a DSM-IV syndrome known as hallucinogen persisting perception disorder (HPPD). We studied 38 HPPD subjects with a mean of 9.7 years of persistent visual hallucinations and 33 control subjects. Measures of local and medium distance EEG spectral coherence were calculated from all subjects. Coherence, a measure of spectral similarity over time, may estimate cortical coupling. In the eyes-open state in HPPD subjects, widespread reduction of coherence was noted. However, upon eye closure, the occipital region demonstrated augmented regional coherence over many frequencies but with reduced coherence of the occipital region to more distant regions. This occipital coherence increase correlated with previously reported shortened occipital visual evoked potential latency for HPPD subjects. We speculate from coherence and known clinical and psychophysical data that, in HPPD, there is widespread cortical inhibition in the eyes-opened state, but localized and isolated occipital disinhibition upon eye closure, a state known to facilitate hallucinatory experiences. An analogy is drawn to findings in the interictal and ictal epileptic focus. In HPPD, we speculate that occipital EEG hypersynchrony resulting from increased regional coherence, when coupled with relative isolation of visual cortex, especially upon eye closure, facilitates hallucinations and illusions.
PMID: 11566431 [PubMed - indexed for MEDLINE]
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