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MDMA is associated with long-lasting increases in serotonin2A receptor density

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The recreational use of MDMA is associated with long-lasting increases in serotonin2A receptor density. Serotonin2A receptor levels correlate positively with lifetime MDMA use and do not decrease with abstinence. These results suggest that MDMA use produces chronic serotonin neurotoxicity in humans. Given the broad role of serotonin in human brain function, the possibility for therapeutic MDMA use, and the widespread recreational popularity of this drug, these results have critical public health implications.


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That would explain why so many do poorly on SSRIs

Also, many dopaminergic neurons interface with MDMA receptors. So increasing dopamine would allow these neurons to do their job correctly (if there is damage with them). Dopaminergic neurons are known to enhance signal-to-noise ratios. This is done by the dual function of dopamine - D1 family receptors (D1 and D5) are direct acting, D2 family receptors (D2, D3 and D4) are inverse acting (they reduce neural activity when receiving a dopamine neurotransmitter). This allow the dopamine neuron to control/switch activity of the receiving neurons. [clear as mud? :blink: ]

This may be part of how Keppra works.

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