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Neuroleptic 5-HT 2A antagonists contraindicated?


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Hi,

 

I am new to this forum. I have been suffering from HPPD/palinopsia since i was 17 years old. Now i am 21. It started after using psilocybin, DXM, nitrous oxide and cannabis very frequently and mixed together. I have been clean from psychedelics for about 2 years now and my HPPD symptoms became less prominent and annoying.

 

Recently i was prescribed risperidone. After taking it my HPPD symptoms increased quite a bit. Colors looked "fake" like in cartoon movies, and i saw halo's/tracers around people and objects. Also the typical visual snow was present. Risperidone works primarily as a 5-HT 2A antagonist. The receptor that plays a major role in psychedelics and HPPD.

 

Now my psychiatrist proposed pipamperon, an even stronger 5-HT 2A antagonist.

 

 

 

I know that 5-HT 2A agonists like psilocybin and LSD are for sure contraindicated in people with HPPD. But what about 5-HT 2A antagonists from the neuroleptic class? Will they permanently exacerbate HPPD symptoms or only when the drug is present in your system?

 

 

 

 

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