Jump to content

Neuroleptic 5-HT 2A antagonists contraindicated?

Recommended Posts



I am new to this forum. I have been suffering from HPPD/palinopsia since i was 17 years old. Now i am 21. It started after using psilocybin, DXM, nitrous oxide and cannabis very frequently and mixed together. I have been clean from psychedelics for about 2 years now and my HPPD symptoms became less prominent and annoying.


Recently i was prescribed risperidone. After taking it my HPPD symptoms increased quite a bit. Colors looked "fake" like in cartoon movies, and i saw halo's/tracers around people and objects. Also the typical visual snow was present. Risperidone works primarily as a 5-HT 2A antagonist. The receptor that plays a major role in psychedelics and HPPD.


Now my psychiatrist proposed pipamperon, an even stronger 5-HT 2A antagonist.




I know that 5-HT 2A agonists like psilocybin and LSD are for sure contraindicated in people with HPPD. But what about 5-HT 2A antagonists from the neuroleptic class? Will they permanently exacerbate HPPD symptoms or only when the drug is present in your system?





Link to comment
Share on other sites

Join the conversation

You can post now and register later. If you have an account, sign in now to post with your account.

Reply to this topic...

×   Pasted as rich text.   Paste as plain text instead

  Only 75 emoji are allowed.

×   Your link has been automatically embedded.   Display as a link instead

×   Your previous content has been restored.   Clear editor

×   You cannot paste images directly. Upload or insert images from URL.


  • Create New...

Important Information

By using this site, you agree to our Terms of Use.