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Dr. Bosio and sleep deprived EEG


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HI all,


So today i had my first visit with Dr. Bosio, who was kindly suggested me by a member of this forum and who's the author of this article:



Levetiracetam efficacy in Hallucinogen Persisting Perception Disorders:

a prospective study. Casa, B, Bosio, A. Drug Monitoring Service, New

York NY; USA; Mater Dei Clinic, Rome, Italy. Journal of the Neurological

Sciences, Volume 238, Supplement 1, 2005, p. S504.


Abstracts of the XVIIIth World Congress of Neurology


"Background: The occurrence of flashbacks following use of drugs is a

recognised condition known as Hallucinogen Persisting Perception

Disorders (HPPD), therapy for wlffch is based on neuroleptic and

attticonvulsant medication. Tiffs prospective study assessed the efficacy

of the novel antiepileptic drug levetiracetam (LEV) in treating patients

with HPPD over a 1-year period.


Method: Patients with HPPD were treated with LEV 1500 mg/day

(500 mg in the morning, 1000 mg in the evening) for 1 year. Daily

flashback frequency and electroencephalogram (EEG) assessments

were conducted at Day 0, 15, 30, 60, 90, 180 and 360. The incidence of

adverse events was monitored throughout the study.


Results: 27 patients (121 males, 6 females), with a mean age of 21.8

(range 18-26) years, were enrolled. At baseline, mean daily flashback

frequency was 9.3 (range 1-45) and EEG assessment demonstrated

temporal slow patterns in all patients. Over the 1-year treatment

period, 20/27 (74.1% ) patients became flashback-free. After 15 days,

7/27 (25.9% ) patients were already without clinical manifestations,

with 6 patients demonstrating > 75% reduction in flashback frequency

and 1 demonstrating 50-75% reduction. EEG patterns normalised in

18/27 (66.7% ) patients after 30 days and in 23/27 (85.2% ) after

90 days. 3/27 (11.1% ) patients continued to have flashbacks, despite

complete disappearance of EEG abnormalities. Side effects were

few in incidence and mild in severity. No patient discontinued



Conclusions: This study demonstrated LEV to be highly efficacious in

the treatment of HPPD, with very good tolerability and ease of use."






In the past few months, before meeting him, I’ve seen 10 doctors who obviously didn’t know shit about HPPD. Thankfully he does and he told me I have it.


He told me very honestly that the 30% of those who have it will never heal and that a way to know if i’m among them is to have a sleep-deprived EEG (my normal EEG, PET and RMI were all negative). 


After the result he’ll decide how to go about it. In the meanwhile he prescribed me DELECIT 600 (http://www.dica33.it/DELECIT/?f=rwxufkxupz)..

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Good KATE! You hace found a doctor that is studying hppd in Italy. A lot of americans hppders had used him study to get a script of keppra from their pshychiatrist/doctor. You are treated by the italian Abraham! Haha.

What's delecit? Any vitamin support to sleep? Never had heared about it, so, I suppose it help with sleep for sleep-deprived eeg. Can you to explain me what's that test?

And about treatment, had he said something about Levetiracetam? You have to do eeg or wait first with delecit or what.

I'm glad to see you being treated by the italian Abraham, or better, a hppd literate pshychiatrist. If I were you, I would be happy. What good lucky!

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Delecit is choline alfoscerate:


Choline Alfoscerate is actually found naturally in the human body to some degree and in the fatty acids of soy plants. It features a chemical structure of [(2S)-2,3-Dihydroxypropyl] 2-trimethylazaniumylethyl phosphate and is also known as L-Alpha Glycerylphosphorylchoine. The Choline Alfoscerate supplements used today are typically derived from soya phospholipids and are marketed under the name Alpha GPC. There has been a lot of research into this nootropic supplement of late as it is seen as a potential treatment for Alzheimer’s disease and stroke patients. It is also used for non-medicinal reasons by people who want to increase their memory, improve analytical skills and achieve greater focus and better attention spans. 


As with other forms of Choline supplements, Choline Alfoscerate aids in the conversion and synthesis of important neurotransmitters within the brain. Part of what makes this so effective as a source of Choline is that it has exceptionally high absorption into the bloodstream and easily crosses over into the central nervous system via the Blood Brain Barrier. Once engaged with the CNS, this supplement is a critical factor in the production of Acetylcholine.

Acetylcholine is a neurotransmitter responsible for a number of cognitive activities due to its role in memory formation and information processing. It is made by combining choline with acetate in your neurons, but often a lack of choline can contribute to low uptake for this neurotransmitter. Choline Alfoscerate is known to increase this uptake so that more acetylcholine can be produced which leads to better communication between neurons and higher levels of brain cell functioning.

The primary benefits of Alpha GPC are broadly categorized as cognitive enhancements. This includes an improved overall memory and recall ability along with enhanced learning capacity. You may find that you do not have to work as hard to remember even minute details and that you have greater access to your long-term memory storage.

This is one of the reasons why people who take Choline Alfoscerate often say that it makes them feel smarter. Some users also report having noticed lengthened attention spans and increased focus and concentration. It is also common to experience more energy and even higher levels of motivation and vitality.

Choline Alfoscerate also helps with maintenance of nerves, neurons, and overall brain health. The supplement bonds with an omega-3 fatty acid known as DHA. This is done through an enzyme process which also builds new cell membranes (for neurons) and promotes the expansion of nerve cells. There is further evidence to suggest that this supplement also supports the production of human growth hormone in a healthy way. This makes Choline Alfoscerate quite attractive to elderly individuals since increased levels of HGH actually can make the body feel and act younger. Also, many body builders and weight lifters seek this benefit since HGH is an effective muscle building agent.


Bosio said he wanna wait for the result of the sleep deprived EEG before talking about levetiracetam..

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Oh, I have hear that people taking noopeps (such piracetam, aniracetam) take choline also, I think for increase the positive effects of that "intelligent" drugs.

What is sleep deprivated eeg? He did you a eeg without slept last night? I wish it will show something (not wrong, only a evidence to found what's happening with you).

How is your delecit trial? Any effects today?

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I had an awake/asleep EEG.  Results were negative.  Don't expect to see anything on it unless you have seizure activity (which is a good thing to find out!).  You're very lucky to have a doctor who understands your condition.  I haven't met one yet that has even heard of HPPD, including the neurologist I saw.  Best of luck with everything!

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I'll meet him again next week and I'll ask him..

Which medicines did u try? Be positive :)


Yes, I am more positive now since I started Keppra, 250 mg twice a day. I talked to my neurologist today which is great. She will refer me to other specialist for a possible QEEG and upcoming PET-scans. I will double the dose starting in January as it seems quite effective. I had anomalies in the left temporal lobe and probably at the lingual gyrus too but that wasn't shown in the EEG.

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