onedayillsailagain

IRC channel?
edit: the tongue thing is horrible. A foreign serpent with a life of it's own, whilst my teeth feel like they swim in my mouth.

Thanks!
Hmm I think I used 250mg orally (mornings) for like 2 weeks, along with all co-factors (eggs everyday + 2g DHA I believe it was). Never noticed the slightest thing.
Hope it helps you though! Personally I'm kind of letting go of the thought that simple supplements can help.. Really think it's going to be one of the novel substances that might help, not some wishy washy half-assed Piracetam kind of thing. I'm talking a7nAChR agonists, NMDAR agonists, KOR antagonists, neurogenics, and perhaps mAChR agonists.. in any case; something with a lot more 'umph' than the average bro-science "theanine's the shit" type of thing. Sure some things have helped along the way (tDCS, Passiflora, Damiana, Kava Kava, CBD, Coluracetam, etc.), but truth be told I haven't seen anything substantial that has persisted in effects so far. Getting way off topic though, haha. Sorry if that was a buzzkill!
Anyhow, guess I'll see how valid this view is soon.

Hmm I'm just gonna funk around a bit the first day; 10 and 20 mg doses spaced 2-3 hours apart.}
If I use 40mg.day I'll have enough for 25 days though, so I think eventually I'll just stick with 20mg BID, or at least until my phosphate batch arrives.
Nothing is set in stone; just gonna play with it and see where it leads me.

Will do! Yes I saw that post; but I'm just going to stick with phosphate doses nonetheless.
Plan is to start with 10mg, then do 10mg increments until I notice negative effects (if I do), then go back one step and stay on that dose, possibly increasing to BID or TID. Oh, and dosing will be sublingual.

I received my NSI-189 from nyles7 today, so I'll be trying it out starting tomorrow.
Fingers crossed...

There are studies indicating pro/prebiotics raise neutrophic factors in the brain, however I haven't tried it. This because I sincerely doubt something like that will make any substantial change.

Music has been ruined for me too most of the time; I can't sing along to my favourite songs due to speech issues as well as simply not remembering the lyrics of songs I knew by heart, yet when I do listen to music, I'll have snippets echoing in my head all day long. I used to sing every day; not that I was any good at it, but it sure made for a much better mood.
This is why I try to listen to music without lyrics these days.. classical guitar radio etc. Last night I couldn't sleep because I kept hearing "Got to be bold, in your endeavours.." over and over..

Well I inquired with Newmind; the only place I know for now that sells it. I don't mind if it's racemic; L-cyclo should be anxiolytic.

Yep. Definitely. Straightening my eyebrows, touching my nose, rubbing my scalp.. stuff like that. Guess they're unconscious "reality checks".
edit: I totally forgot about Kava Kava.. I'm gonna order a bunch tomorrow; it's one of the few things that reliably reduce my anxiety. Have you tried it?
edit2; BTW these behaviours are new to me.

Hmm I don't know. Whichever comes first I'll try first.
Still waiting for an answer about whether it's racemic or merely (very) impure, before I order.

Alright; thanks for the feedback. Think I'm gonna go with 50mg of D-cycloserine instead.. see where that takes me.

Stay strong man, we're all working towards finding something that helps. This is usually my consolation; perhaps it's something you can stay busy with as well.
In the meantime just try to stay occupied and take things one day at a time.

Err.. Ch bitartrate+Inositol combo was about a week, but that was one of my first attempts (year or more ago). Sarcosine trial lasted a week.. again; perhaps I should take it longer, but I wanted to do a "flush". Indeed no negatives experienced from NMDAR agonism, so it's at least tolerable. Still think current options are not nearly potent enough though.
Cheers.

Bump. I'm currently not taking anything (... first time in ages), and wondering if this is worth a shot.
Anyone here taking it or took it in the past, and experienced benefits (not visually per se, looking more for nootropic/anxiolytic effects)?
Seems that benefits are slight to mild at best..

Ohh I meant that in the worst case I get scammed and get sold Inositol posed as NSI-189, for example. I'm not actually buying Inositol (I hope ).
I've tried Inositol/Ch Bitartrate 50/50 combination at those high doses.. Never did anything for me, but that may be due to a hell of a lot of choline.
Nope; haven't considered DMAE myself. Good to hear you're feeling better though!

As for NMDA agonism; tried Sarcosine for up to 3 grams B.I.D. with 3-5 grams Glycine to no avail.. Perhaps too weak, perhaps I should try longer. D-cyclo is still an option, but I'd have to cautiously look into dosage, cause potential side effects don't look great (e.g. psychosis). As for Newmind's D-cyclo; if the other 40% is L-cyclo, it wouldn't be too much of an issue, considering L-cyclo has some interesting properties that could be beneficial as well. NRX-1074's structure is expected to be public early 2014, so that's one to look out for.

If neither NSI-189 or 7,8-DHF help me, I think I'm going to go benzo style on this until the rest of my wish list is available. Damned cocaine.
Cheers guys.

I have these symptoms as well. I think, perhaps in part, it may be interrelated with DP/DR, as I find I also have a general lack of environmental/spatial awareness at all times, which doesn't seem to be related to visual symptoms, but rather as if not every part of the picture is registering in to my consciousness. Perhaps improved spatial awareness will also help build a stronger sense of direction; this is something I find severely lacking when transporting myself.

In any case, it does seem to hold more merit than merely micromanaging neurotransmitters/receptors.
As for 7,8-DHF; it should be significantly more potent than Cerebrolysin at agonizing TrkB.
Anyway; I've ordered a gram of NSI-189 off of eBay, hoping it'll last me until my 5 gram batch arrives.
Dunno how legit it is, but I'm tired of waiting, and I thought the worst that could happen is that I just get sold Inositol instead or something.
Should be here within 2 weeks or so, so I'll be sure to update when it arrives.

https://www.youtube.com/watch?v=2AnuX827JtA

Yeah it's in stock; so no need for synthesis (which tends to be the longest step anyway).

Hehe... Hmm I'd say end of January to be safe. 1st of January is the cut-off for joining, this is when the order will be placed. For further info you can contact "socialpiranha" @ LC.

My bad; thought it was there. I paid $70 for 1 gram.

Hey guys,

so lately with NSI-189 and all I've been looking in to neurogenic substances. Maybe some of you have heard of this small molecule.
7,8 dihydroxyflavone (7,8-DHF), is a potent agonist at the TrkB receptor. More about the TrkB receptor here.

Here's one study in particular I find interesting:
 

 

Interestingly, chronic oral administration of 4'-dimethylamino-7,8-dihydroxyflavone and its lead (note: its lead being 7,8-DHF) strongly promotes neurogenesis in dentate gyrus and demonstrates marked antidepressant effects. Hence, our data support that the synthetic 4'-dimethylamino-7,8-dihydroxyflavone and its lead both are orally bioavailable TrkB agonists and possess potent antidepressant effects.

A Synthetic 7,8-Dihydroxyflavone Derivative Promotes Neurogenesis and Exhibits Potent Antidepressant Effect

and:

 

Whereas current anti-depressant and anti-anxiety medications take 1-2 months to take effect, and frequently produce very harsh side effects, 7,8-dihydroxyflavone is a potent anti-depressant that demonstrates therapeutic efficacy within a few days.

 7,8-Dihydroxyflavone and its Derivatives Useful for Treatment of Neurodegenerative Diseases

and

Yes, ever since my condition worsened I've feared going demented or insane on a daily basis. So much noise in my head (random stuff like "it's raining gold" when it's not even raining). Previously I had intrusive thoughts that were manageable, but now, coupled with a worsening of cognition and heavier perceptual shifts, it's becoming a real burden. And I too find myself thinking on a frequent basis: " I don't know how much longer I can put up with this shit ".

I feel like I'm at the end of the line.. the only things I might hope to be able to improve my situation are pharmacological, and of those I've very few ideas left.
So I catch myself thinking: " Well, if this doesn't work, I'm utterly screwed".

Well.. in any case you could always try Clonazepam. I'm keeping that as a last resort, but you may want to look in to it if you're having a hard time getting through the day.
Also, fear of insanity is common with DP, so you're not alone with that. Other than that, try to keep yourself occupied. Even if it's merely watching TV series.
And, doctors can be a real pain. Some may require a lot of persistence before they give in, so try to keep pushing. Good luck.

Sorry for never replying to all that Sam. Interesting stuff you posted though!
Anyways; JDTic synthesis seems to be coming along finally. See here.
So anyone who's interested; please post in that thread. Thanks

edit: Personally I'd prefer to see feedback from his first group buy to confirm legitimacy, trustworthiness, etc. before buying, so perhaps to anyone interested that is also something to keep in mind. You can find it here.

Aaauuuugggghhh - - - why don't we all just get well and have a party!?!

Well this is of course mandatory should we find a proper treatment/cure