AmitV

How long did it take for it to start easing? Did anything specific help with it?

It was a delayed onset

Listed in section 4 lot of over the counter options bacaical skullcap is my favorite. Tincture from I iherb is pretty relaxing. but lots and lots of options. Careful not to pick the (antagonists). I’m not sure of the modulator class either. https://www.intechopen.com/chapters/78514

Please start low, I recommend 50mg. Not too much. Since it works via enzymes and works like a vitamin that builds up overtime. I would say, slow titration every 2 weeks.

Anyone here who also has tinnitus and eventually got better or went away? Ive had tinnitus now for almost 10 months.

It was the combination. the panic attack from lsd and anti-gaba properties of antibiotic. For reference: the drugs listed here on page 3 are the ones to avoid going forward. Forget that it refers to akathisia, it’s the same mechanism. Brings all the craziness forward in the mind. https://akathisiaalliance.org/wp-content/uploads/2024/01/Guide-for-Clinicians-012224-editable.pdf My best recommendation to counter this effect. And it’s not straightforward 10 day recovery. It takes time. niacinamide - 3000 mg/day P5P - as tolerated (increases GAD enzyme) converts glutamate to gaba gotu kola - as tolerated (increases gad enzyme) converts glutamate to gaba Hydroxy b12 - as tolerated (increases comt enzyme, breaks down serotonin, dopamine and norepinephrine in frontal cortex- stress relax) lavender oil capsules - used for restlessness and agitation (take as tolerated) Antioxidants (glutathione, NaC) - reduces overall glutamate. The goal is reduce glutamate, increase gaba. Breakdown dopamine (hyper arousal), norepinephrine (sympathetic stress), lower serotonin. glutamate - stress gaba - relax dopamine - hyperarousal, can be calming for some norepinephrine- sympathetic stress (breathing difficulties, palpitations, blood pressure) serotonin - it’s a hoax!

Not particularly. But I had a lot more symptoms, that went away with it. As I understand HPPD, PPPD, VSS are all Functional Neurological Disorders from Trauma or brain trying to get rid of stress. Have to recognize if that stress is coming from past trauma or medication-encited event like akathisia and dyskinesia and treat accordingly. If someone has specifically "childhood" trauma, they should consider EMDR trauma therapy as well.. Functional neurological disorder (FND) | NHS inform | NHS inform All of this coming from stress/stuck in fight-flight/inner turmoil. The amygdala has deep connections to visual perception, vestibular, auditory, and sensory processing centers. Calm the amygdala down with treating your trauma and these problems go away. Naturally, this is not a psychotic condition, symptoms are 100% real! But people don't have the proper understanding of psycho-somatic/functional neurological, symptoms are fucking real! You're not crazy, you and I are in pain! It's fucking hell! The brain does this to protect you from pain (PTSD), because it feels you're injured. Resolve the pain/trauma and the check engine light goes off, and symptoms go away. This has nothing to do with serotonin, this is dopamine, gaba and norepinephrine. So try all kinds in the form of supplements, gaba enhancers like P5P, gotu kola, niacinamide. Noepinepherine reducers like clonidine, magnesium l-threo. Or Dopamine agonists, if dopamine agonists make you worse, then check if you have slow comt or overmethylating and load up on niacinamide and hydroxy b12. All the success stories from clonazepam, are simply that the amygdala stayed calmed down for 2 months and abolished the maladaptive circuit. You go off it, knowing how FND's emerge due to pain and trauma, and the pain of withdrawals kick it back up again, some only experience mild withdrawals. Clonidine utilized in some older pieces of HPPD literature, lowers norepinephrine in the amygdala (lowers stress response). So ideal candidates are things that stick such as P5P, niacinamide and some more. See youtube link below. Breathing exercises and distraction, greatly help. Not everything works for everyone as you know, so it can be a bit of an effort to figure out what works, if it does you will feel the racing thoughts in your mind slowing down within 3-5 days. This is the same problem with drug-induced akathisia, what works for one makes another person worse. If it works, it works in less than 7 days! The same thing many have reported on this forum with some meds, works really quick if you strike the right one! Strangely akathisia is also a dopamine and gaba problem, that flips the switch on drug induced inner turmoil/trauma. The racing mind is a function of trauma/pain, which causes HPPD, VSS, PPPD, Head Pressure, muscle stiffness, tremors, and fatigue in the form of functional symptoms, previously known as conversion disorder. "Converts" mental trauma/fear to neurological symptoms. Most people with HPPD will attest that the one event brought a lot of traumas forward in the mind and can't stop the mind from racing, although they are more preoccupied with the symptoms than the mental comorbidity. Truth is have to calm the mind, for the symptoms to resolve. Benzos do that, but well you know what happens with tolerance, withdrawal, etc. Until such time underlying trauma/racing mind/trauma is resolved, symptoms will morph from one to the next, 6 months hppd, then pppd, then head pressure, then something else, then a lot of mixed symptoms. So benzos aren't a solution, benzos are sedating and suppressing trauma resolution pathways, that's why they cause dissociation. If trauma is suppressed, it has to come out in some way, it'll show up as dissociation.

Its just OTC active vitamin b6, not the regular b6. I got it off iherb

I've had the exact same experience, except I got tinnitus, vss, hppd, disequilibrium and akathisia. Fucked me up royally. Was able to get the akathisia (agitation, head zaps, body zaps) and dyskinesia (tremors, twitches) to stop with Niacinamide and P5P. I'm 15 months out, things have gotten better, but I'm still between the couch and the bed, thankfully I disability payments that come from my employer, so I'm just getting by for now, at a snails pace. Microsoft Word - 1976-v05n01-p004.doc (isom.ca) Pyridoxal-5-Phosphate and Akathisia - RxISK

If dopamine enhancers made anyone worse, then try the opposite.

Did anyone try clonidine, as per numerous online resources?

The best recommendation I can give you, is an understanding that HPPD is a functional neurological disorder. Past Trauma, stressful lives, toxic exposures, infections, medication toxicity, turn down good genes, fires up the fight-flight center to keep you safe. The drug is gone, but the brain still feels unsafe (fearful - Ultimate fear) because of the original injury. Racing thoughts in the mind at 3000mph. The fight-flight center has deep connections to the visual perceptual (VSS, HPPD), auditory (tinnitus), limbic (pins and needles), motor (tremors, twitches, etc. ) and vestibular functions (dizziness). It creates maladaptive pathways to keep you safe and bedridden. That's why Klonopin works, because it targets the fight-flight (amygdala), once the amygdala calms down, the brain begins to feel safe and begins to ditch the maladaptive pathways to visual, auditory and vestibular systems. But you can do the same with nutritional supplements (megadoses of certain ones) and breathing exercises (calm down the speed of thoughts). But there is another way! Custom supplements to support the genes that have been turned down by trauma or drug use. By utilizing specific nutritional supplements to support the downregulated enzymes. I ran a 23&me test, didn't care about the 23&me crap. Uploaded raw data to geneticgenie (free), and nutrihacker (free). This is what I got. Attached. Here's another drug-induced dyskinesia article that may help, that explain how megadose can reset the fight-flight system. Microsoft Word - 1976-v05n01-p004.doc (isom.ca)

supplements and meds both can be hit or miss. What works great for one, does not for the other. This is true amongst all kinds of psychiatric and neurological disorders.

I recently did a QEEG which showed hyperactivity in my right temporal lobe. Which includes the amygdala (fight-flight), hippocampus. The temporal lobe has deep connections to limbic, auditory, visual perceptual centres of the brain. Essentially the treatment is breathing exercises, slowing down thoughts, distraction, trauma therapy. https://my.clevelandclinic.org/health/body/16799-temporal-lobe The QEEG I did also lines up with the below application of RTMS for HPPD. but the temporal lobe also responds to epilepsy medications and supplements in calming the temporal lobe in temporal lobe epilepsies. It’s also an area affected in schizophrenia. HPPD isn’t a psychiatric disorder, but a functional neurological disorder. https://www.nhsinform.scot/illnesses-and-conditions/brain-nerves-and-spinal-cord/functional-neurological-disorder/ which is why clonazepam, keppra, memantine, magnesium and several other epilepsy supplements sometimes work. Epilepsy diet which is primarily keto diet is also helpful. increase gaba and decrease glutamate (antioxidants and magnesium), can help. Niacin according to my research in high dosages is highly applicable. Saturating the brain with niacin leads to immense relief from oxidative stress, overall stress, calming of thoughts, it reduces methylation, is utilized in schizophrenia, ptsd, and several related conditions such as drug induced akathisia and dyskinesias.

Yes SSRI trintellix started it. As far as I’m aware trintellix is a glutamate agonist and was modelled as an antidepressant after mushrooms.