Gill82

 I don't think it's cell death or would we not be seizure prone? I've also had MRIs that have showed no lesions.  My guess would be a possibly a change at the receptor  or connection level.

 I don't think this is ever going away in my case.  Of course this is just me, I'm not saying it won't happen to others.   Seems like a permenat disinhibition in the brain.  Good news:  I'm rarely bothered by it anymore.   But there was a flare up today which is why I thought about coming here.  It's amazing how sensitive the brain is to chems with HPPD.   All I took was a nutritional supp for recovery that was L-glutamine and taurine.  Woke up in pastel/cartoon colored world.   That's okay though, my HPPD symtoms always get better after these temporary flare-ups.  Never have gotten worse overall. 

I think the thing that helped me most was dealing with Depersonalization and Derealization.  In the first few years I thought DP/DR and HPPD were a single condition. They seem connected, yes, but I was able to greatly reduce the DP/DR. Once this happens, and I no longer felt like I was looking at the world through a bubble, the HPPD symtoms became less noticeable and more in the background.  So if I could give any advice , it would be to go after the DP/DR.  You may not even realize that this is what is giving you the most problem.  I didn't... just thought it was all HPPD.

How to deal with DP/DR...  people have a lot of different suggestions.  Obviously avoiding drugs/alcohol...reducing anxiety, specificly ,  OCD-type.   Once I reduced this, the DP/DR reduced.  And an SSRI sertraline I took reduced it alot.  Unfortunately ,  I avoided SSRIs for years because people said they usually made symptoms worse.   It did, in the beginning.  But I decided to stick with it and after several months my DP/DR was greatly reduced and so was my obsession.   So I wouldn't discount this type of med. 

Good luck to you all...

I've had hppd for 13 years. There are plenty of things that can aggravate my hppd. However,  the symptoms have always gone back to baseline.  Never gotten overall worse.