Diperidon

Usually GCPR's are upregulated upon treatment with an antagonist. However 5-HT2A is an exception. Both 5-HT2A agonists AND antagonists downregulate 5-HT2A receptors. Having too much 5-HT2A receptors can result in depression, anxiety, OCD and schizofrenia.

Hi,

I am new to this forum. I have been suffering from HPPD/palinopsia since i was 17 years old. Now i am 21. It started after using psilocybin, DXM, nitrous oxide and cannabis very frequently and mixed together. I have been clean from psychedelics for about 2 years now and my HPPD symptoms became less prominent and annoying.

Recently i was prescribed risperidone. After taking it my HPPD symptoms increased quite a bit. Colors looked "fake" like in cartoon movies, and i saw halo's/tracers around people and objects. Also the typical visual snow was present. Risperidone works primarily as a 5-HT 2A antagonist. The receptor that plays a major role in psychedelics and HPPD.

Now my psychiatrist proposed pipamperon, an even stronger 5-HT 2A antagonist.

I know that 5-HT 2A agonists like psilocybin and LSD are for sure contraindicated in people with HPPD. But what about 5-HT 2A antagonists from the neuroleptic class? Will they permanently exacerbate HPPD symptoms or only when the drug is present in your system?