tropicalpalmtree

No disrespect at all, just getting ideas out there mate! 

Give this a look, its an old post but shows some promise. https://www.shroomery.org/forums/showflat.php/Number/15506267

I have started taking the resveratrol today, i will try for a few weeks, if its no good its another idea for the recycle bin 

and it costs a shit ton of money to buy, i mean a 30 day dose would be in the 10s of thousands of pounds/dollars

The resveratrol and quercetin are widely used supplements and have some safety profile so it'll be okay. If i can get hold of a specialist who knows a thing or two about CLP-290 though i would be enquiring in depth about its possible use for visual disturbances, i would be worried however taking this drug without prior information due to its obscurity. 

15 hours ago, Jay1 said:

2mg of klonopin reduces my VS and BFEP by about 80%, so there is a clear neurological issue that can be targeted.

Could you still function properly on this dosage or were you spaced out? it would be interesting to see this working, just out of curiousity. 

Just for information sake, i have purchased both resveratrol & quercetin to try on a 3 month basis, resveratrol in particular was indentified as a potent KCC2 modulator by the whitehead institute of biomedical research, alongside several other compounds. I have purchased 500mg/day capsules for both.

 

https://www.genengnews.com/topics/drug-discovery/paralyzed-mice-walk-following-drug-therapy/

this is pretty amazing with CLP-290 KCC2 manipulation, its method of action seems very encouraging for hppd

https://www.cell.com/cell-reports/pdf/S2211-1247(19)30759-4.pdf

https://www.mdpi.com/2073-4409/9/1/240/htm

i really hope i find someone that can decipher it all, i know its medical text and needs to be written in such a way, but its infuriating how complicated it all is. If only there were a google translate into layman's terms 

4 hours ago, SS1 said:

dephosporylation and phosphorylation (adding or removing a phosphate acts as an on/off switch; for some proteins its "on" others "off" and vice versa.... It's like a cascade of events, usually another protein known as a kinase would add the phosphate group, one the phosphate is added, the complex would work to stimulate something else (could be transcriptional changes, apoptosis, etc....) somewhere else along the cascade/pathway)

From what I gather, https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4381966/, it appears that if this protein is phosphorylated, it is inhibited. Dephosphorylated, it is activated. Although, I'm still trying to figure out which is good and which is bad, the dephosporylation or the phosphorylation. In any case, its just a theory, there are so many theories for so many conditions/diseases. I would be curious to here about exogenous substances that could affect its modulation, from that article it seems to play a role in epilepsy, neuropathic pain, and spasticity, conditions.

Has anyone tried to explain it to you? - I'd be interested in hearing more about it.

Not yet man, but i have bought some Quercetin supplement which is a KCC2 activator. There are stronger drugs i've seen mentioned, one of particular interest to me was CLP-290, a novel prodrug which was the only drug listed on a research document as being revolutionary for KCC2 modulation! have a look on google, it may be of some interest. 

does anyone know anything about this protein and its effect on neurogenesis? i find it incredibly hard to understand the complicated research literature, so i'm not sure if this is flogging a dead horse. Its regulation seems to be a key in several neurological conditions. Again i'm not sure what i am really reading, i just hope this could be a lead to something in depth.

I hope someone can pop up and explain how this system works.

thanks

its obvious that sleep plays a HUGE factor in hppd and recovery, but does anyone know why or even think they know?

this is not necessarily true, the thing with hppd is too little sleep causes temporarily worsening of visuals and so does too much, i don't think it really plays much of a part in serious recovery other than relaxing the mind and the rest the body needs anyway. i'm close to 3 years in now and i cant say that sleep has done anything more to progress my recovery than abstaining from hard drugs and pot. the one think i do notice is that my hppd is usually best for the first 1 1/2 hours after waking up (visuals are pretty mild nowadays but still very noticeable) not sure why this is but its the same everyday

Does anyone has a shock inside the head? I feel this is bad.. I'm new here.. I dont know where else I could get help. I have had this a long time and i eat lamotrigin 100mg and klonopin 0,5mg 3 x in day. i have pressure in my head and i see lots of things. micropsia and macropsia, visuals, afterimages, and  i see star flights all the time.. is this hppd? I had received a serotonin syndrome a year ago and then  i ate mushrooms, cubensis. not a much..

do you take any ssri's? i had these "brain shocks" about 3 years ago a few months before i actually got hppd, and i believe its ssri discontinuation syndrome (i wasnt on anti-depressents but the symptoms are so similar, look it up), the shocks subsided after a 2 weeks and never had them again, so you should be good 

http://en.wikipedia.org/wiki/Antidepressant_discontinuation_syndrome