Mushubeans

So in your case, sinemet alone reduced your HPPD and DP? What mechanism would underlie that?

Studies have shown that Sinemet can improve symptoms of HPPD and I know some of the members on the forum have found this to be true in their own experiences. This poses a question.. All along, antipsychotics have been cautioned against when it comes to treating HPPD because of their antagonization of the 5-HT2a receptor. Could this be totally wrong? Could the reason antipsychotics worsen HPPD have to do with their lowering of dopamine? It would seem a likely possibility considering that by raising dopamine, Sinemet ameliorates many of the symptoms, including depersonalization which antipsychotics also tend to exacerbate. I'd love some input on this!

Has it made your symptoms worse? If not then it's not a big deal. If it is making them worse then stop taking it. It made mine worse the first time I took it

Don't take it! Hydroxyzine is an Antipsychotic which is a big no-no if you have HPPD. It made mine permanently worse