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Case analysis of long-term negative psychological responses to psychedelics


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This is a REALLY good, well-written find, man... and I'm glad it was published in Nature.

They bring up a good point that I think is often overlooked, as I highlight in bold: dosage

"Distilling the information gathered from this approach, we felt we were able to identify some consistent themes across the sample pertaining to the question of causality. These variables can be categorised into 3 major domains: namely, (1) factors pertaining to the individual’s psychological vulnerability (including their young age), (2) (negative) set, setting and/or matrix factors, and (3) factors linked to the substance itself—and most commonly, its (excessively high) dose and particular action. It is worth noting that these factors are entirely consistent with those highlighted in previous work in relation to the hypothesised context-dependency of responses to psychedelics [e.g., see Fig. 2 in30].

 

Outside of plasticity they also mention drug mixing.  I know in my case there was a mixture of drugs (cannabis and LSD) and the LSD dosage, though it was a single tab, was very high as my friends had related to me later.  The potency of the drug in relation to the emergence of this disorder, mixed with peculiar, perhaps genetic sensitivity in some subset of population, is at least to my knowledge something that hasn't been studied as much as it should... though granted I have little idea of how it could be studied objectively.

 

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