Irritability - nature vs nurture vs HPPD

[yarkadin]

Here's a fun topic for everyone. 

Who here with HPPD notices unusual irritability in themselves?  There are a million reasons for any of us to be irritable including myriad genetic factors (that would apply with or without HPPD) and I am solidly in the determinism camp in matters of free will... but I have this feeling it's all become worse almost despite my better instincts due to my condition.  This especially applies to external noise where it's getting close to a kind of hyperacusis.  I have this feeling that all of this pent up pressure and stress of dealing with entoptic phenomena, trails, afterimages and so forth has lead to this manifestation... where I sometimes surprise myself with my exaggerated irritation at the smallest things (and lingering anger).  On the other hand, I also realize the role of genetics in this. 

One of the things I keenly remember Henry Abraham telling me years ago in our phone conversation is that I and others with HPPD "most probably" have a genetic susceptibility.

Digression/rambling: If a subset of humans have a genetic predisposition toward being hyper-sensitive to hallucinogens, are there a subset who are impervious to hallucinogenic complications?  What differences between our genetics exactly can be found and could this open up some form of "gene therapy" for HPPD and visual snow sufferers?  I'm sure this must have been discussed before, if anyone has links or more info I would love to learn more.

Edited August 14 by yarkadin

[James3524]

45 minutes ago, yarkadin said:

Here's a fun topic for everyone. 

Who here with HPPD notices unusual irritability in themselves?  There are a million reasons for any of us to be irritable including myriad genetic factors (that would apply with or without HPPD) and I am solidly in the determinism camp in matters of free will... but I have this feeling it's all become worse almost despite my better instincts due to my condition.  This especially applies to external noise where it's getting close to a kind of hyperacusis.  I have this feeling that all of this pent up pressure and stress of dealing with entoptic phenomena, trails, afterimages and so forth has lead to this manifestation... where I sometimes surprise myself with my exaggerated irritation at the smallest things (and lingering anger).  On the other hand, I also realize the role of genetics in this. 

One of the things I keenly remember Henry Abraham telling me years ago in our phone conversation is that I and others with HPPD "most probably" have a genetic susceptibility.

Digression/rambling: If a subset of humans have a genetic predisposition toward being hyper-sensitive to hallucinogens, are there a subset who are impervious to hallucinogenic complications?  What differences between our genetics exactly can be found and could this open up some form of "gene therapy" for HPPD and visual snow sufferers?  I'm sure this must have been discussed before, if anyone has links or more info I would love to learn more.

Good question: To the best of my knowledge, there haven't been any genetic markers found that are linked to a predisposition to developing HPPD. However, the Visual Snow Initiative is planning on funding some studies to find a genetic marker, probably within the next year or two. In regards to gene therapy, I have no clue, but I will do some research. 

Anecdotally, there does indeed seem to be a link between a history of migraine, especially with a visual aura implicated (myself, included), and HPPD/VSS. Not sure if a genetic marker has been found for that. 

[AF44]

On 8/13/2024 at 5:50 PM, yarkadin said:

Here's a fun topic for everyone. 

Who here with HPPD notices unusual irritability in themselves?  There are a million reasons for any of us to be irritable including myriad genetic factors (that would apply with or without HPPD) and I am solidly in the determinism camp in matters of free will... but I have this feeling it's all become worse almost despite my better instincts due to my condition.  This especially applies to external noise where it's getting close to a kind of hyperacusis.  I have this feeling that all of this pent up pressure and stress of dealing with entoptic phenomena, trails, afterimages and so forth has lead to this manifestation... where I sometimes surprise myself with my exaggerated irritation at the smallest things (and lingering anger).  On the other hand, I also realize the role of genetics in this. 

One of the things I keenly remember Henry Abraham telling me years ago in our phone conversation is that I and others with HPPD "most probably" have a genetic susceptibility.

Digression/rambling: If a subset of humans have a genetic predisposition toward being hyper-sensitive to hallucinogens, are there a subset who are impervious to hallucinogenic complications?  What differences between our genetics exactly can be found and could this open up some form of "gene therapy" for HPPD and visual snow sufferers?  I'm sure this must have been discussed before, if anyone has links or more info I would love to learn more.

Interesting! The only thing I can say is that when mine acts up I definitely get more irritable because it’s well…irritating and trying to deal with it at the same time as trying to deal with everything else in life is so frustrating. But…I was irritable as a little kid, and into my teens and 20’s. Weirdly so. It had to do with waking up. When I was a kid my mom would wake me up for school and she’d flip on my light and say, “Up and at ‘em!” and I would be so mad and I thought she was saying “Up and Adam” and I could never figure out who Adam was. I was so pissy no o e was allowed to look at or speak to me. I would eat my cereal with the box blocking me because I would be furious if I caught anyone looking at me, and I didn’t want to look at anyone. By the time I’d get done eating and get dressed, I was fine. When my parents split up, my brother and I visited our dad every other weekend. He did his laundry at the laundromat early on Saturday mornings. It got so bad when he’d wake me up, he resorted to buying an Entemen’s coffee cake for me because I loved coffee cake and it would immediately tamp down my anger. Hm. Is this normal? Like, is this what you mean by being genetically disposed to irritability/anger?

[AF44]

3 minutes ago, AF44 said:

Interesting! The only thing I can say is that when mine acts up I definitely get more irritable because it’s well…irritating and trying to deal with it at the same time as trying to deal with everything else in life is so frustrating. But…I was irritable as a little kid, and into my teens and 20’s. Weirdly so. It had to do with waking up. When I was a kid my mom would wake me up for school and she’d flip on my light and say, “Up and at ‘em!” and I would be so mad and I thought she was saying “Up and Adam” and I could never figure out who Adam was. I was so pissy no o e was allowed to look at or speak to me. I would eat my cereal with the box blocking me because I would be furious if I caught anyone looking at me, and I didn’t want to look at anyone. By the time I’d get done eating and get dressed, I was fine. When my parents split up, my brother and I visited our dad every other weekend. He did his laundry at the laundromat early on Saturday mornings. It got so bad when he’d wake me up, he resorted to buying an Entemen’s coffee cake for me because I loved coffee cake and it would immediately tamp down my anger. Hm. Is this normal? Like, is this what you mean by being genetically disposed to irritability/anger?

Oh yeah, also furious and horrid upon waking into my teens and 20’s…people were terrified to wake me up. I would go OFF. Then it stopped being that way. Idk

[yarkadin]

11 hours ago, AF44 said:

Interesting! The only thing I can say is that when mine acts up I definitely get more irritable because it’s well…irritating and trying to deal with it at the same time as trying to deal with everything else in life is so frustrating. But…I was irritable as a little kid, and into my teens and 20’s. Weirdly so. It had to do with waking up. When I was a kid my mom would wake me up for school and she’d flip on my light and say, “Up and at ‘em!” and I would be so mad and I thought she was saying “Up and Adam” and I could never figure out who Adam was. I was so pissy no o e was allowed to look at or speak to me. I would eat my cereal with the box blocking me because I would be furious if I caught anyone looking at me, and I didn’t want to look at anyone. By the time I’d get done eating and get dressed, I was fine. When my parents split up, my brother and I visited our dad every other weekend. He did his laundry at the laundromat early on Saturday mornings. It got so bad when he’d wake me up, he resorted to buying an Entemen’s coffee cake for me because I loved coffee cake and it would immediately tamp down my anger. Hm. Is this normal? Like, is this what you mean by being genetically disposed to irritability/anger?

Haha... I was the same, by the way... though I didn't get the "up and Adam" line.  My mother was running around like crazy each morning, like her hair was on fire, and would keep pushing me to wake up every 10 minutes even before my alarm clock was set to go off.  It's funny I'm remembering all of this now, I haven't thought about it in years.  It was quite frustrating as I used to be a deep sleeper and a night owl.  I still am a night owl though I tend to get exhausted by around 1 AM.  With time that deep sleep is no longer the case and I can wake up with some random noise.  Of course tranquilizers and other drugs help with sleep.

I just wanted to open up a discussion if others have this irritation problem.  It's probably a very plain psychological outcome of stress tethered to genetics and nothing inherent in HPPD itself.

[James3524]

@AF44 We had the exact same experience; I would also get very irritable when waking up as a kid. I remember my mom would ask if I was 'up in atoms,' and I always thought she was referring to atoms, but maybe she meant Adam. I was usually only partially conscious, sometimes even dreaming, and would get very confused and annoyed by what my mom was saying when she was trying to get me up.

Interestingly, I saw on another thread that you mentioned having an eidetic memory as a child. I experienced the same, though it seemed to fade as I entered my teenage years. I was talking to my Dad a few weeks ago, and he shared that he had a remarkable memory as a child, to the point where my grandmother was often amazed by it. However, his eidetic memory also diminished during his teenage years, despite him never using recreational drugs 

It’s possible that many of us could be distant cousins! James Fulton, a Vision scientist, estimated that around 50,000 to 60,000 people might have a predisposition to HPPD/VSS. If we go back approximately 10 generations, which is roughly 250 to 300 years, each person would have 1,024 direct ancestors (in theory because there could be intermixing of pedigrees). These ancestors likely had multiple children, particularly in the Anglosphere, potentially leading to a huge number of descendants.

It seems like most people with HPPD/VSS are from the U.S, U.K, Australia, or Sweden. Maybe it’s because those countries have higher rates of hallucinogenic drug use, a greater prevalence of people with this genetic predisposition, or a mix of both.

[yarkadin]

23 hours ago, James3524 said:

@AF44 It seems like most people with HPPD/VSS are from the U.S, U.K, Australia, or Sweden. Maybe it’s because those countries have higher rates of hallucinogenic drug use, a greater prevalence of people with this genetic predisposition, or a mix of both.

US, UK, Australia (also New Zealand and Canada) are the Anglosphere and are the countries where people would most likely find this website.  People in the Scandinavian countries also are all bilingual with their respective languages and English.  I was in Norway and Finland and I know they are taught English from an early age.  Would be nice to find some broad pattern to exclude misleading variables and biases but I think it will take a massive amount of research.  I myself am Russian and was not born in the United States.

Edited August 19 by yarkadin

[yarkadin]

On 8/18/2024 at 11:51 AM, James3524 said:

It’s possible that many of us could be distant cousins! James Fulton, a Vision scientist, estimated that around 50,000 to 60,000 people might have a predisposition to HPPD/VSS. If we go back approximately 10 generations, which is roughly 250 to 300 years, each person would have 1,024 direct ancestors (in theory because there could be intermixing of pedigrees). These ancestors likely had multiple children, particularly in the Anglosphere, potentially leading to a huge number of descendants.

BTW, this is a very interesting point... I read about this several years ago.  Going back just a few hundred years, the number of ancestors of a given person rises to exponential, almost absurd-on-the-surface levels.  We are talking about someone in the 1600s having potentially a million ancestors.  This gets conflated by inter-marriage though, where ancestors are repeated over and over in the same family tree.  I'm no genealogist but there is a mathematical method to all of this that can be researched.  It's also intuitive given that we have evolved from small bands of hunter-gatherers.

At the time mass agriculture started some 20,000 years ago there were estimates of 1 million people.  Those are our ancestors.  There are presently 8.2 billion people on earth, so this is (correct me if my math is off) about 0.0125 of the present population.

Edited August 19 by yarkadin

[AF44]

On 8/18/2024 at 8:51 AM, James3524 said:

@AF44 We had the exact same experience; I would also get very irritable when waking up as a kid. I remember my mom would ask if I was 'up in atoms,' and I always thought she was referring to atoms, but maybe she meant Adam. I was usually only partially conscious, sometimes even dreaming, and would get very confused and annoyed by what my mom was saying when she was trying to get me up.

Interestingly, I saw on another thread that you mentioned having an eidetic memory as a child. I experienced the same, though it seemed to fade as I entered my teenage years. I was talking to my Dad a few weeks ago, and he shared that he had a remarkable memory as a child, to the point where my grandmother was often amazed by it. However, his eidetic memory also diminished during his teenage years, despite him never using recreational drugs 

It’s possible that many of us could be distant cousins! James Fulton, a Vision scientist, estimated that around 50,000 to 60,000 people might have a predisposition to HPPD/VSS. If we go back approximately 10 generations, which is roughly 250 to 300 years, each person would have 1,024 direct ancestors (in theory because there could be intermixing of pedigrees). These ancestors likely had multiple children, particularly in the Anglosphere, potentially leading to a huge number of descendants.

It seems like most people with HPPD/VSS are from the U.S, U.K, Australia, or Sweden. Maybe it’s because those countries have higher rates of hallucinogenic drug use, a greater prevalence of people with this genetic predisposition, or a mix of both.

That’s crazy!! Maybe we are somehow distantly related! I thought I was the only one who would go crazy pissed upon waking. Like, it was SO over the top. And yes, I did have an eidetic memory, it did sort of fade by my teen years but my memory was still pretty sharp into my early 20’s. (Not as good as when I was a kid though) Now it’s like I have dementia. It’s so depressing and actually very frightening. My dad is basically a genius but I almost think he might be autistic as well, now that I look back. My brother and I would have a calculator and make him add a bunch of big numbers in his head and check to see if he was right. He always was. He’s spit out the answer immediately. We would even have him multiply 3 digit numbers (like say, 143 times 236) and again, he’d know the answer right off. He has a really good job and is 72 now and refuses to retire. The company he works for wanted to keep him so bad they gave him a raise and a big bonus, I found out. Daddy doesn’t talk too much about money but he had 2 beers and let it slip However…he is uh, very interesting when it comes to other stuff. My mom told me a story (before I was born) that there was some kind of party or get-together for my dad’s work. She said they had it done up really fancy. You came in and there was a podium with a guest book. There was an (unlit) white tapered candle on one side and one of those old fashioned feathered ink well pens on the other side to sign the book with. So my dad walks up, grabs the candle, and tries to sign the book with it. My mom and his boss were standing there and mom was mortified! She said he even licked his fingers to straighten the wick. His boss said, “Come on, Sherri, he’ll figure it out” and they went into the banquet room. A minute later my dad comes in with his face as red as a tomato Another time when I was little, I’d had a bath and Daddy was getting me dressed. He put my t-shirt on upside down. Like, he put the collar over my head. My arms were trapped. I totally remember it. I was waddling around like a penguin and my dad was yelling to my mom that something was wrong with me cuz I wasn’t walking right. So she comes out and says, “You put her t-shirt on upside down!” So I secretly referred to my dad as Rainman. He was such a genius about everything else though and probably had an awesome memory as well.

[AF44]

On 8/19/2024 at 8:55 AM, yarkadin said:

BTW, this is a very interesting point... I read about this several years ago.  Going back just a few hundred years, the number of ancestors of a given person rises to exponential, almost absurd-on-the-surface levels.  We are talking about someone in the 1600s having potentially a million ancestors.  This gets conflated by inter-marriage though, where ancestors are repeated over and over in the same family tree.  I'm no genealogist but there is a mathematical method to all of this that can be researched.  It's also intuitive given that we have evolved from small bands of hunter-gatherers.

At the time mass agriculture started some 20,000 years ago there were estimates of 1 million people.  Those are our ancestors.  There are presently 8.2 billion people on earth, so this is (correct me if my math is off) about 0.0125 of the present population.

 

On 8/19/2024 at 8:55 AM, yarkadin said:

BTW, this is a very interesting point... I read about this several years ago.  Going back just a few hundred years, the number of ancestors of a given person rises to exponential, almost absurd-on-the-surface levels.  We are talking about someone in the 1600s having potentially a million ancestors.  This gets conflated by inter-marriage though, where ancestors are repeated over and over in the same family tree.  I'm no genealogist but there is a mathematical method to all of this that can be researched.  It's also intuitive given that we have evolved from small bands of hunter-gatherers.

At the time mass agriculture started some 20,000 years ago there were estimates of 1 million people.  Those are our ancestors.  There are presently 8.2 billion people on earth, so this is (correct me if my math is off) about 0.0125 of the present population.

So you mentioned that 50,000 to 60,000 people are predisposed to HPPD/VSS? My son (16) has HPPD. It’s horrible. I’ve mentioned it on here and talked to Jay several times because I was devastated. I always wondered if there was a genetic predisposition to HPPD, because what are the chances a mother has it, then her son gets it?

[yarkadin]

41 minutes ago, AF44 said:

 

So you mentioned that 50,000 to 60,000 people are predisposed to HPPD/VSS? My son (16) has HPPD. It’s horrible. I’ve mentioned it on here and talked to Jay several times because I was devastated. I always wondered if there was a genetic predisposition to HPPD, because what are the chances a mother has it, then her son gets it?

What I'd like to know is... how, given your experiences, did he take those same drugs?  Not pointing blame, a person old enough will do his/her own thing and cannot be stopped.  But they can be educated.

[yarkadin]

I'm going to guess that HPPD susceptibility is in my bloodline as it is for others.  If this is the case, it seems reasonable to think that there are bloodlines immune to HPPD.  If the problem had the same funding and priority as common illnesses I am willing to bet that there would already be some kind of official, point-specific treatment for it.

Edited August 20 by yarkadin

[AF44]

23 hours ago, yarkadin said:

What I'd like to know is... how, given your experiences, did he take those same drugs?  Not pointing blame, a person old enough will do his/her own thing and cannot be stopped.  But they can be educated.

[AF44]

Just now, AF44 said:

23 hours ago, yarkadin said:

What I'd like to know is... how, given your experiences, did he take those same drugs?  Not pointing blame, a person old enough will do his/her own thing and cannot be stopped.  But they can be educated.

Oops hit wrong button. I warned my kids about the dangers of drugs their whole lives, just as every parent does. And a lot of kids experiment anyway. And are sneaky enough to get away with it a lot of the time. My son did not get this from a hallucinogen. Most likely some kind of whatever the hell is in a dab pen or some kind of weed. Not his fault, not my fault.

[yarkadin]

1 hour ago, AF44 said:

Oops hit wrong button. I warned my kids about the dangers of drugs their whole lives, just as every parent does. And a lot of kids experiment anyway. And are sneaky enough to get away with it a lot of the time. My son did not get this from a hallucinogen. Most likely some kind of whatever the hell is in a dab pen or some kind of weed. Not his fault, not my fault.

Definitely not assigning blame... Please don't get me wrong.  Just rather surprised.  It is an odd situation.  Never heard of a "dab pen" either...

Edited August 21 by yarkadin

[AF44]

21 hours ago, yarkadin said:

Definitely not assigning blame... Please don't get me wrong.  Just rather surprised.  It is an odd situation.  Never heard of a "dab pen" either...

Yeah I didn’t know what a dab pen was either. My kids know what they are and tried to explain it to me but I still don’t get it. They said it’s weed but like, times 10 or something crazy. And I guess there are ones that have part THC and part something else. God only knows. I have tried so hard but kids just do what they do, they want to experiment…I’ve busted my sons a couple times and they were punished (grounded, weed thrown out, etc.) I have/had zero qualms about searching their rooms when they’re not home…IF I suspect something. And I’ve been proven right more than once. (Mainly just pot.) But one time I searched my (HPPD) son’s room thinking he was doing that damn dab pen and instead I found a bottle of empty cough syrup hidden in his dresser drawer. And not even the brand I buy. So I confronted him and he copped to it. Like wth. Of all things. I couldn’t believe it. Last Halloween, long story, we went through 3 bottles of that damn Halloween hairspray as part of his costume. He has thick hair almost to his waist. Even the 3 bottles weren’t enough. The fumes were terrible. It was right after that that he got it really bad I guess. I always blamed the hairspray, but recently he admitted to me that he’s had the HPPD symptoms but they got WAY worse after the hairspray fumes. Seems to have settled (I pray) but he still has it. I HATE it so much. And my husband and I don’t want him on any meds. My husband said unless it was “the last resort.” Cuz after Halloween it was so bad he was running to my room every night claiming he thought he’d had a stroke or all sorts of odd things, prob from anxiety, and he barely passed the 10th grade. Poor kid. I never in a million years dreamed one of my kids would get it. I thought maybe it would happen if they did LSD for example, but…Idk. That’s why I wondered if there was a genetic component to it.

[yarkadin]

So sorry about this... but this story, although it's anecdotal, does lead me in the direction of thinking we have some genetic markers as James mentioned earlier.  I think this may be more widespread than we think.  But who knows... we have over 8 billion people on earth... we have some people who are completely immune from AIDS and other illnesses.  Can you imagine... an HPPD vaccine?  It would be too late for us now, I suppose. 

Edited August 22 by yarkadin

[James3524]

22 hours ago, yarkadin said:

Definitely not assigning blame... Please don't get me wrong.  Just rather surprised.  It is an odd situation.  Never heard of a "dab pen" either...

A dab pen is a vape that uses a cartridge with THC oil concentrate. I haven't smoked in over 4 years, but if I remember correctly, the concentrate is usually stronger than the raw plant. 

[AF44]

20 hours ago, yarkadin said:

So sorry about this... but this story, although it's anecdotal, does lead me in the direction of thinking we have some genetic markers as James mentioned earlier.  I think this may be more widespread than we think.  But who knows... we have over 8 billion people on earth... we have some people who are completely immune from AIDS and other illnesses.  Can you imagine... an HPPD vaccine?  It would be too late for us now, I suppose. 

Omg an HPPD vaccine…if possible that would be amazing.

[AF44]

20 hours ago, James3524 said:

A dab pen is a vape that uses a cartridge with THC oil concentrate. I haven't smoked in over 4 years, but if I remember correctly, the concentrate is usually stronger than the raw plant. 

I did know they were stronger than regular weed but I didn’t know why or if there was other stuff in the pen to go along with the THC. I’d never even heard of a dab pen until (years ago) my older son mentioned that someone had one at school. This is sooo stupid, but he said someone he knew did a dab and I thought he was talking about that stupid dab pose

[James3524]

On 8/19/2024 at 11:55 AM, yarkadin said:

BTW, this is a very interesting point... I read about this several years ago.  Going back just a few hundred years, the number of ancestors of a given person rises to exponential, almost absurd-on-the-surface levels.  We are talking about someone in the 1600s having potentially a million ancestors.  This gets conflated by inter-marriage though, where ancestors are repeated over and over in the same family tree.  I'm no genealogist but there is a mathematical method to all of this that can be researched.  It's also intuitive given that we have evolved from small bands of hunter-gatherers.

At the time mass agriculture started some 20,000 years ago there were estimates of 1 million people.  Those are our ancestors.  There are presently 8.2 billion people on earth, so this is (correct me if my math is off) about 0.0125 of the present population.

Indeed. I found this fun fact on my 23andME:

“If you have European ancestry, you’re probably descended from Charlemagne. The authors of a recent study estimated that every European who lived over 1,000 years ago — and left descendants — is very likely the ancestor of every ethnically European person alive today. And Charlemagne, King of the Franks, was particularly prolific, siring around 20 known children.

It might sound counterintuitive, but it has to do with something called “pedigree collapse,” or a folding-in of the human family tree. We have 4 grandparents, 8 great-grandparents and — skipping ahead a bit here — over 1,000 10th-great-grandparents. If we follow this logic back over 40 generations to the time of Charlemagne, we should each have more than a trillion ancestors. But this would be impossible (that’s over 10 times the total number of humans estimated to have ever lived). If you go far enough back in time, your pedigree is actually “collapsing” in on itself over and over again, with many of your ancestors showing up on multiple branches of your family tree.”

 

[AF44]

15 hours ago, James3524 said:

Indeed. I found this fun fact on my 23andME:

 

“If you have European ancestry, you’re probably descended from Charlemagne. The authors of a recent study estimated that every European who lived over 1,000 years ago — and left descendants — is very likely the ancestor of every ethnically European person alive today. And Charlemagne, King of the Franks, was particularly prolific, siring around 20 known children.

It might sound counterintuitive, but it has to do with something called “pedigree collapse,” or a folding-in of the human family tree. We have 4 grandparents, 8 great-grandparents and — skipping ahead a bit here — over 1,000 10th-great-grandparents. If we follow this logic back over 40 generations to the time of Charlemagne, we should each have more than a trillion ancestors. But this would be impossible (that’s over 10 times the total number of humans estimated to have ever lived). If you go far enough back in time, your pedigree is actually “collapsing” in on itself over and over again, with many of your ancestors showing up on multiple branches of your family tree.”

 

I am 100% of European ancestry. 

[AF44]

Just now, AF44 said:

I am 100% of European ancestry. 

Does this mean we are more prone to getting HPPD? I kind of forgot what we were talking about That’s just me tho. Can’t concentrate worth a damn anymore.

[yarkadin]

We just went off on a tangent on ancestors and descendants   I think it is a fascinating subject but not really connected to the immediate subject this spilled into, namely genetic susceptibility to HPPD.

[James3524]

 

On 8/24/2024 at 2:53 PM, AF44 said:

Does this mean we are more prone to getting HPPD? I kind of forgot what we were talking about That’s just me tho. Can’t concentrate worth a damn anymore.

The genetic predisposition to HPPD seems quite rare. Most people of European descent can take hallucinogens hundreds of times without developing HPPD. I'm 100% European as well: 25% British, 25% Polish, 25% Irish, around 20% German, and a little bit of Swedish,