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Experience with MAO Inhibitors/Advice on Antidepressants


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Hi Guys,

Been on and off this forum since I got HPPD 6 years ago but never posted.

I'd had a solid 4 years of stability and thought I was well on the road to accepting the condition and dealing with my new life. (I got HPPD in 2014 after taking LSD for the first and only time - tho I had been doing MDMA and Weed for a while before).

Sadly that all changed early this year. I took on a massively stressful project at work late last year and by the end of Jan my DP/DR was suddenly through the roof (no change in visuals tho). I was getting jamais vu every day and getting these emotions/memories that just didn't feel like mine. I tried to just keep going with the hope that it would recede again ... it didn't.  Unfortunately, It's been like a perfect storm with Covid-19. When Lockdown happened I was stuck by myself for like 2 months and it just spiralled. In short I now realise that I'm properly depressed in a way I've never been before. Obviously, I'm freaking out cus I know how SSRI's can go down. I tried 1 10mg amitriptyline (TCA) just before LD and it just made me feel super narsty so I didn't continue (no affect on my HPPD tbf tho). I've read some people do ok on Wellbutrin but I've also seen people say it doesn't work for long. I've been wondering whether anyone has had any experience with taking MAOi's - I've searched thru previous posts and haven't found much (apologies if I've just missed it I'm not really with it atm)? TBH I'd be really grateful for any recommendations at this point.

 

TLDR: Has anyone tried MAOi for depression - any feedback on how it affected their HPPD?

 

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  • 5 months later...

Selegiline is fine for me but not when I am experiencing acute symptoms. I don’t recommend anything but maoi-b until you really understand your hppd. Maoi-a is much “dirtier” in its mechanisms and I’ve never tried those. 
 

it can be hard to differentiate what neurotransmitter systems are causing what specific emotions. Took me a lot of trial and error and I still am very much in the dark, although it’s getting to sunrise haha. 
 

 

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