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Any thoughts on this medication as a possible means to ameliorate HPPD?


How do these neurosteroid drugs relieve depression?

The drugs are mildly sedating. They interact with GABA receptors in the brain. GABA is the major inhibitory neurotransmitter in the brains of all mammals, so an agent that augments GABA can be sedating. In fact, the biggest challenge with brexanalone for postpartum depression is the potential for excessive sedation. Sleepiness also affected some of the patients who took SAGE-217, but that's not necessarily bad because sleep disturbances are a big problem in depression and in a range of psychiatric illnesses. The drug may relieve depression at lower doses, without causing the sedation that was seen in some patients in the clinical trial, but that needs to be tested.


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