Jump to content

Has anyone tried phosphatidylserine?

Recommended Posts

It seems like it could be a beneficial thing to supplement all around, with few if any downsides (save being quite pricey). Feeling much less with it today than usual so I'll just let these extracts do the talking:


NYU Langone Medical Center:
"Phosphatidylserine, or PS for short, is a member of a class of chemical compounds known as phospholipids. PS is an essential component in all our cells; specifically, it is a major component of the cell membrane. The cell membrane is a kind of "skin" that surrounds living cells. Besides keeping cells intact, this membrane performs vital functions such as moving nutrients into cells and pumping waste products out of them. PS plays an important role in many of these functions.


Good evidence suggests that PS can help declining mental function and depression in the elderly, and it is widely used for this purpose in Italy, Scandinavia, and other parts of Europe. PS has also been marketed as a "brain booster" for people of all ages, said to sharpen memory and increase thinking ability. However, the evidence to support this use is incomplete and inconsistent."







In otherwise healthy young adults given 400mg PS for 2 weeks, a significant improvement in processing speed (20%) and accuracy (13% more correct responses, 39% less wrong responses) is noted relative to placebo and independent of mood state.[22]


Phosphatidylserine appears to promote attention and reduce symptoms of ADHD, and when the phosphatidylserine molecule contains the Fish Oil fatty acids then it may promote attention to an even greater degree 


Stress has been noted to be reduced with doses as low as 60mg in otherwise healthy men, although this study is confounded with the inclusion of Fish Oil (and stress was only significantly reduced at rest in high stressed persons);[1] it has been replicated elsewhere with phosphatidylserine in isolation with 42 days supplementation of 200mg phosphatidylserine (as protein bar) where induced stresses were less than control (and associated with less beta-1 wave function in the right hemisphere).[28] This same dose and supplementation vessel has been used in young golfers given 200mg phosphatidylserine for 42 days, where a 21.6% increase in drive accuracy (percentage of straight shots) was thought to be secondary to a stress reducing effect.[29]


In other cognitive disease states, persons with Parkinson's disease given bovine cerebral phosphatidylserine note some degree of improvement on EEG parameters[41] and in general dementia 300mg of bovine cortex phosphatidylserine has noted some degree of benefit within 3 weeks of a 6 week trial[42] and has improved memory and depressive symptoms in persons suffering from geriatric depression.[43]


PS supplementation has been implicated in increased spatial memory in aged rats at 50mg/kg (human equivalent of 8mg/kg or 550mg for a 150lb person)[44] and has been noted at lower concentrations (5-20mg/kg) when injected into aged rats, where improvements in grooming and behaviour retention are noted.[45]

Studies in non-aged rats (to establish a Nootropic effect rather than cognitive rehabilitative effect) using 50mg/kg bodyweight for 27 days was able to significantly enhance brightness discrimination (indicative of memory formation) without significantly affecting anxiety or depressive symptoms.[46]





First pilot studies indicate that PS supplementation might be beneficial for children with attention-deficit hyperactivity disorder.[17][18]

A follow-up study backed up previous findings. The study found children supplementing with 200 mg PS per day for two months saw a significant improvement in ADHD symptoms.[19]





Make sure to research and suss it out for yourself of course, as with anything there are some lukewarm opinions and studies around. I'll definitely be looking into this further though.


  • Upvote 1
Link to comment
Share on other sites

  • 3 weeks later...

I have taken it in capsulated gel form it hads beenone of a few supplaments that work get a good sorce and it will help with memory I hate wasting money on supps so I only report what works and it has really helped me but for some reason the non powdered form is much better you can also get it from eating sardines, its expensive stuff.

Link to comment
Share on other sites

Create an account or sign in to comment

You need to be a member in order to leave a comment

Create an account

Sign up for a new account in our community. It's easy!

Register a new account

Sign in

Already have an account? Sign in here.

Sign In Now

  • Create New...

Important Information

By using this site, you agree to our Terms of Use.