Jay1 Posted August 20, 2013 Report Share Posted August 20, 2013 Starting on 5mg x 3 per day. It usually takes 3-4 weeks to see results (if it works). I'll keep this up to date. The nuero says it is pretty mild stuff and only for low-mid range anxiety, but worth a shot. http://en.wikipedia.org/wiki/Buspirone Link to comment Share on other sites More sharing options...
onedayillsailagain Posted August 21, 2013 Report Share Posted August 21, 2013 Good luck jay! Hope it's at the very least palliative. 1 Link to comment Share on other sites More sharing options...
Sam93 Posted August 21, 2013 Report Share Posted August 21, 2013 I was looking into this too but the serotonin and dopamine agonism put me off a bit, but hope it works out mate, all the best. Link to comment Share on other sites More sharing options...
Jay1 Posted August 28, 2013 Author Report Share Posted August 28, 2013 Cheers lads. Just a quick update after a week. No bad side effects, no changes in visuals. I mild reduction in anxiety... A bit like that protective bubble you get with a very low dose of klonopin. Quite interesting as it is supposed to build for 3-4 weeks. Might just be placebo though, so I will report back again when at the 3 week stage. Link to comment Share on other sites More sharing options...
StateOfRegret Posted August 28, 2013 Report Share Posted August 28, 2013 Interesting. Thanks for the update :-) I've read about buspirone on SocialAnxietySupport. It seems that it is generally well-tolerated but, for most people, not very effective. There are exceptions, however :-) Link to comment Share on other sites More sharing options...
Jay1 Posted August 28, 2013 Author Report Share Posted August 28, 2013 Yep, even my neuro didn't think much of it and only usually uses it as an add-on to SSRIs, but worth a go. Link to comment Share on other sites More sharing options...
Jay1 Posted September 3, 2013 Author Report Share Posted September 3, 2013 An interesting note.... I have had my parents in law here for 10 days... This tends to mean that i drink a bit more than normal. On Sunday, i drank 2 large beers, 2 gin and lemons (strong ones), a bottle of beer and a large glass of wine.... This would normally have me reaching for 1mg of Klono the next day... Especially as i had a meeting with the bank manager. To my surprise, i woke up completely fine and had zero anxiety in the bank. Maybe the mild serotonin and dopamine effects of the medicine helped. Link to comment Share on other sites More sharing options...
Ghormeh Sabzi Posted September 3, 2013 Report Share Posted September 3, 2013 Sounds ... positive. I've got another one for you to consider later on perhaps: http://hppdonline.com/index.php?/topic/2261-tiagabine/ Link to comment Share on other sites More sharing options...
Jay1 Posted September 3, 2013 Author Report Share Posted September 3, 2013 I have a feeling i have tried that already.... If only the old board was still available Link to comment Share on other sites More sharing options...
Ghormeh Sabzi Posted September 3, 2013 Report Share Posted September 3, 2013 If only ... I was thinking of trying it myself for some pain I experience. Link to comment Share on other sites More sharing options...
Jay1 Posted September 30, 2013 Author Report Share Posted September 30, 2013 Just a quick update. This is no magic bullet, but I feel might benefit some. It takes the edges off my life and has even given me a bit of love back into life. Each week seems to be a little better.... not visually or even with dp/dr, zero change there... It just seems to give me a protective blanket against the racing thoughts and almost physical pain of hppd. I'm gonna up my dosage next week, i'll keep ya posted. Link to comment Share on other sites More sharing options...
andrewcb Posted September 30, 2013 Report Share Posted September 30, 2013 I was started on 15mg hcl buspar I believe it was and holy moley when I would go to sleep it would give me some realistic creepy day dreams. I couldn't tell if they if I was sleeping or just daydreaming sometimes lol. Wish I had some more didn't do much for me but was fun to take a few before bed. GL Link to comment Share on other sites More sharing options...
onedayillsailagain Posted October 2, 2013 Report Share Posted October 2, 2013 Good to hear jay! Hope it sustains itself Link to comment Share on other sites More sharing options...
Jay1 Posted October 3, 2013 Author Report Share Posted October 3, 2013 Thanks mate :-) Just a word of caution to anyone who does try this.... I have always being ok taking meds and things like 5-htp and st john's wort.... The only thing i had a big problem with was Prozac. Although this stuff has a reputation of being mild, i can certainly feel effects on my body, like racing pulse and heart palpitation (only for about 10 minutes, an hour after taking). I imagine it could scare some users. Link to comment Share on other sites More sharing options...
StateOfRegret Posted March 1, 2014 Report Share Posted March 1, 2014 Hey Jay - did you continue taking buspirone? What's the score? Link to comment Share on other sites More sharing options...
Jay1 Posted March 2, 2014 Author Report Share Posted March 2, 2014 Hi, I moved back to UK from Portugal... In the craziness of the move, I forgot to get a repeat prescription from my Portuguese neuro. I cannot get it (or Clonazepam) from my doctor in UK, even though i have a letter from my neuro in Portugal. Trying to find a proper neuro here. I will go see my neuro in Portugal in April and hopefully he can provide me with a 6 month refill. Link to comment Share on other sites More sharing options...
BigPapaChakra Posted March 4, 2014 Report Share Posted March 4, 2014 Hey, I just posted this in the HPPD Stack thread, and it's highly relevant: "We used in vitro neurogenesis-based human neural stem cell (hNSCs) assays and rodent in vivo behavioral assays to identify potential novel antidepressants. A combination of buspirone and melatonin displayed antidepressant activity in these assays whereas neither buspirone nor melatonin alone showed any antidepressant-like profile. After evaluating numerous combination ratios, we determined that low dose buspirone 15 mg combined with melatonin-SR 3 mg yielded optimal antidepressant efficacy in our pre-clinical platform. The low dose of buspirone suggested that antidepressant efficacy might be achieved with only minimal adverse event liability. Based on these data, we conducted an exploratory 6-week, multi-center, double-blind, randomized, placebo- and comparator-controlled study of the combination of buspirone and melatonin in subjects with acute Major Depressive Disorder (MDD). The combination treatment revealed a significant antidepressant response in subjects with MDD on several measures (Clinical Global Impression of Severity and Improvement, Inventory of Depressive Symptomatology) compared to either placebo or buspirone 15 mg monotherapy. These preliminary findings have clinical implications and suggest that a platform of pre-clinical neurogenesis matched with confirmatory behavioral assays may be useful as a drug discovery strategy." Link to comment Share on other sites More sharing options...
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