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Flavonols: significant studies

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Ok this is definitely the last one.. really need to sleep.


These experiments showed that intraperitoneal administration of quercetin 4 h before microinjection of NMDA into the third ventricle of the brain increased the duration of the toxic component of convulsive seizures and the severity of convulsions and ataxic symptoms. The same dose and route of quercetin increased the duration of clonic and tonic convulsions but did not alter the severity of convulsive seizures or ataxia symptoms induced by intraperitoneal injection of corazol. These data provide evidence that the Hsp70 expression inhibitor quercetin has anticonvulsant properties.



That one is a bit contradictory.


The results showed that quercetin pretreatment causes a lower seizure intensity in treated kindled rats (p<0.05-0.01), a lower after-discharge duration (p<0.05-0.01), and a higher latency to stage IV (p<0.05) as compared to untreated kindled ones.

source [PDF]


Note to self: check out PMID:16258243 and http://www.ncbi.nlm.nih.gov/pubmed/2173925

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