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Lipoic Acid: relevant studies

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Just creating another stub before I go to bed.


 The EEGs of rats pretreated with ALA and DHLA exhibited 55% less seizure activity than vehicle-treated ferric chloride-injected animals, suggesting that lipoic acids may be of use in preventing or attenuating TBI-induced seizures


Migraine study:

Within-group analyses showed a significant reduction of attack frequency (P= .005), headache days (P= .009), and headache severity (P= .03) in patients treated with thioctic acid for 3 months, while these outcome measures remained unchanged in the placebo group.
This study tends to indicate that thioctic acid may be beneficial in migraine prophylaxis.
N.B. Thioctic acid is a synonym for ALA.



This review provides an overview of the role of mitochondrial oxidative stress and dysfunction in seizure-induced neuronal damage and a potential contributing factor in epileptogenesis. Mitochondria dysfunction can affect ROS production, macromolecule function, bioenergetics, glutamate excitotoxicity, neuronal death, and neuronal excitability. Each of these targets is crucial for normal brain function, and dysfunction in one or more of them may decrease seizure threshold causing the brain to be more susceptible to becoming epileptic. Targeting mitochondrial bioenergetics and oxidative stress with antioxidant and non-pharmacological treatments may prove to be useful in the management of epilepsy and attenuation of its development. Continued research in this area will provide a greater understanding of how mitochondrial oxidative stress and dysfunction contributes to the pathogenesis of TLE and how therapeutic strategies targeting mitochondrial bioenergetics can be used for patients refractory to current antiepileptic treatments.s

source: Mitochondrial Oxidative Stress in Temporal Lobe Epilepsy


The latencies of VEP components were significantly prolonged in the S group and returned to control levels following LA administration. This study showed that LA is protective against sulfite-induced VEP alterations and oxidative stress in the brain and retina.



VEP always has high significance. However, from what I can collect here, is that the latency is shortened by ALA. This would theoretically yield controversial effects, for the EEG patterns of HPPD'ers show an already shortened VEP latency.

Note to self: read "Is it time to reassess alpha lipoic acid and niacinamide therapy in schizophrenia?[PDF]"

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