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Resveratrol: Relevant studies

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Before I start, I'd like to say that with the progression of speculative treatment (in the form of supplements), perhaps one day there'll be a "HPPD Mitigation Complex"! Haha sounds a bit far-fetched, but it would be cool if it worked, especially considering the numerous intrinsic health-benefits most of these supplements exhibit. Imagine that; natural treatment of HPPD that works!

Anyway, down to business.


These results suggest that Resveratrol is a potent anti-epilepsy agent, which protects against epileptogenesis and progression of the kainate-induced TLE animal.



The findings of the present study suggest an antiepileptic potential of resveratrol and that an adenosinergic mechanism may play a role in its anticonvulsant activity.



Herbs and Spices: Unexpected Sources of Antiepileptogenic Drug Treatments? is also of interest, and reports that Curcumin might exhibit anti-convulsant effects. But let's stay focused on Resveratrol for now.


The neurochemical assay showed that higher dose of trans-resveratrol (80 mg/kg) produced a marked increase of 5-HT levels in three brain regions, the frontal cortex, hippocampus and hypothalamus. Noradrenaline and dopamine levels were also increased both in the frontal cortex and striatum. Furthermore, chronic treatment with trans-resveratrol was found to inhibit monoamine oxidase-A (MAO-A) activity in all the four brain regions, particularly in the frontal cortex and hippocampus; while MAO-B activity was not affected. These findings indicate that the antidepressant-like effect of trans-resveratrol involves the regulation of the central serotonin and noradrenaline levels and the related MAO-A activities.



Nuclear respiratory factor 1 (NRF-1) is one of the key transcription factors implicated in mitochondrial biogenesis by activating the transcription of mitochondrial transcription factor A (mtTFA) and subunit genes of respiratory enzymes.
NRF-1 transactivation activity can be enhanced by interaction with transcription coactivator peroxisome proliferator-activated receptor γ coactivator 1α (PGC-1α).

 Here, we use primary cultures of rat visual cortical neurons and a rat model of monocular deprivation (MD) to investigate whether AMP-activated protein kinase (AMPK) is implicated in mediating activity-dependent regulation of PGC-1α and NRF-1 expression in neurons. We find that KCl depolarization rapidly activates AMPK and significantly increases PGC-1α, NRF-1, and mtTFA levels with increased ATP production in neuron cultures. Similarly, pharmacological activation of AMPK with 5′-aminoimidazole-4-carboxamide riboside (AICAR) or resveratrol also markedly increases PGC-1α and NRF-1 mRNA levels in neuron cultures.



Say what? As far as I can collect from this, Resveratrol aids mitochondrial biogenesis, and increases PGC-1a and NRF-1 mRNA levels in the rat visual cortical neurons. I wonder if elevated mRNA levels are considered epigenetic changes? Either way, here's a study that confirms Resveratrol's epigenetic effects.


However, in rats receiving resveratrol after ABM, the calcium intensity, microglial activation, pro-inflammatory cytokine and MDA levels were all significantly decreased. Quantitative data showed that much more hippocampal neurons were survived in resveratrol-treated rats following ABM. As resveratrol successfully rescues hippocampal neurons from ABM by suppressing the calcium-mediated microglial activation, therapeutic use of resveratrol may act as a promising strategy to counteract the ABM-induced neurological damage.



There's a calcium link.. Don't know what to make of it.


Resveratrol has strong anti-aging properties and has been shown to play a neuroprotective role in several neurological disorders by protecting brain cells from death. Recent studies also directly link the beneficial effects of resveratrol to prevention of vision loss (N.b. this is achieved via retinal mediation I believe)
These studies strongly suggest that resveratrol could be useful for treating vision and neurological disorders associated with diverse pathologies.
Resveratrol-pretreated cells also showed a significant decrease in intracellular calcium and an inhibition of caspase-3 activity as compared to the untreated cells.



Resveratrol can improve the cognitive ability of AD (Alzheimer Disease) mice, which may contribute to the resveratrol's antioxidation and antiapoptosis, and can modulate acetylcholinesterase

N.B. Human studies haven't been able to confirm the nootropic effects of Resveratrol. However, they haven't been thorough enough for they've only measured acute effects (from what I can find). You'll see what I mean



Very few studies reported information about RSV effect on cognitive function. For example, Kumar et al. showed that administration of resveratrol in rats that received an intracerebroventricular colchicine injection, known to cause loss of cholinergic neurons and cognitive dysfunction that is associated with excessive free radical generation, had a neuroprotective role against colchicine-induced disturbances . Moreover, Joseph et al. demonstrated that resveratrol and more particularly, one of its most efficacious analogue (pterostilbene) were effective in reversing cognitive behavioral deficits, as well as dopamine release, in aged rats and their working memory was correlated with pterostilbene levels in the hippocampus. These previous results allowed us to expect beneficial effects of this polyphenol on memory performances of mouse lemur (a primate). In the present report we show that both CR (caloric restriction) and RSV supplementation were accompanied by maintained or better cognitive and motor performances after 18 months of chronic treatment. Main effects of treatments were observed in the continuous spontaneous alternation task, in which both CR and RSV supplemented animals presented better performances of total alternation compared to CTL animals. RSV supplementation also significantly lowered the number of errors in the circular platform task compared to CTL whereas CR did not significantly change the performances to this test.



Well that's enough for now, let me just post this.

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