Effect of magnesium on epileptic foci

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Magnesium sulfate was able to directly suppress neuronal burst firing and interictal EEG spike generation at serum levels below those producing paralysis. The degree of suppression corresponded to the serum magnesium concentration and was reversible. These results corroborate the clinical observations in patients that magnesium can produce an anticonvulsant effect apart from neuromuscular blockade and suggest it may have clinical applicability in treating a wider range of acute convulsions.

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